Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27903722)

Published in J Neurosci on November 30, 2016

Authors

Ursula S Sandau1, Mariana Colino-Oliveira2,3, Abbie Jones1, Bounmy Saleumvong1, Shayla Q Coffman1, Long Liu4, Catarina Miranda-Lourenço2,3, Cátia Palminha2,3, Vânia L Batalha3, Yiming Xu5, Yuqing Huo5, Maria J Diógenes2,3, Ana M Sebastião2,3, Detlev Boison6

Author Affiliations

1: R.S. Dow Neurobiology Laboratories and.
2: Institute of Pharmacology and Neurosciences, Faculty of Medicine, Unit of Neurosciences, and.
3: Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal, and.
4: Department of Comparative Medicine, Legacy Research Institute, Portland, Oregon 97232.
5: Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
6: R.S. Dow Neurobiology Laboratories and dboison@downeurobiology.org.

Articles cited by this

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet (1999) 11.79

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A (2001) 2.73

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol (2001) 2.31

Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J Neurosci (2004) 2.25

Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells. J Clin Invest (2003) 2.22

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest (2011) 1.79

Adenosine receptors as drug targets--what are the challenges? Nat Rev Drug Discov (2013) 1.74

The adenosine kinase hypothesis of epileptogenesis. Prog Neurobiol (2007) 1.72

Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci U S A (2002) 1.70

Adenosine receptors and the central nervous system. Handb Exp Pharmacol (2009) 1.53

Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cereb Cortex (2007) 1.48

2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol (1988) 1.47

Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience (2006) 1.46

Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses. J Pharmacol Exp Ther (1994) 1.45

Adenosine A1 receptors are crucial in keeping an epileptic focus localized. Exp Neurol (2006) 1.40

Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia (2003) 1.38

Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. J Cereb Blood Flow Metab (2006) 1.37

Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochim Biophys Acta (2010) 1.32

Adenosine kinase: exploitation for therapeutic gain. Pharmacol Rev (2013) 1.26

Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors. Curr Top Med Chem (2005) 1.24

Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices. J Neurosci (2004) 1.19

Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. Eur J Neurosci (2004) 1.16

Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. Am J Hum Genet (2011) 1.14

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest (2013) 1.09

Silk fibroin encapsulated powder reservoirs for sustained release of adenosine. J Control Release (2010) 1.09

The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8-substituted xanthines. Br J Pharmacol (1990) 1.07

Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus. Neurosci Lett (1992) 1.07

Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. Eur J Neurosci (2003) 1.06

Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides. Br J Pharmacol (1996) 1.04

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation. Mol Psychiatry (2012) 1.03

Engineering embryonic stem cell derived glia for adenosine delivery. Neurosci Lett (2004) 1.02

Regulation of hippocampal synaptic plasticity by BDNF. Brain Res (2014) 1.02

Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy. Neuropharmacology (2011) 1.02

Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine. Neuropharmacology (2008) 0.99

Seizure suppression by adenosine-releasing cells is independent of seizure frequency. Epilepsia (2002) 0.99

Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice. Learn Mem (2011) 0.98

ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. Br J Pharmacol (1997) 0.97

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. J Cereb Blood Flow Metab (2011) 0.95

Enhancement of LTP in aged rats is dependent on endogenous BDNF. Neuropsychopharmacology (2011) 0.94

Adenosine: setting the stage for plasticity. Trends Neurosci (2013) 0.92

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain. Neurobiol Learn Mem (2006) 0.91

Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options. J Inherit Metab Dis (2015) 0.90

Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing. Eur J Neurosci (2011) 0.90

Cued and contextual fear conditioning in mice. Curr Protoc Neurosci (2004) 0.90

Increased amount of extracellular ATP in stimulated hippocampal slices of seizure prone mice. Neurosci Lett (1989) 0.84

The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine. Front Mol Neurosci (2016) 0.82

Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.81

Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation. Brain Res (2014) 0.81

Adenosine A2A antagonists as neurotherapeutics: crossing the bridge. Prog Neurobiol (2007) 0.80

Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice. J Neurosurg (2013) 0.80

Adenosinergic signaling in epilepsy. Neuropharmacology (2015) 0.78