Published in J Cardiovasc Electrophysiol on October 01, 2003
Generation of histo-anatomically representative models of the individual heart: tools and application. Philos Trans A Math Phys Eng Sci (2009) 2.37
Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image-based models and application examples. Philos Trans A Math Phys Eng Sci (2009) 1.12
How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project. J Physiol (2012) 1.05
Regional difference in dynamical property of sinoatrial node pacemaking: role of na+ channel current. Biophys J (2008) 0.99
Uniqueness and stability of action potential models during rest, pacing, and conduction using problem-solving environment. Biophys J (2009) 0.99
Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model. Biophys J (2005) 0.99
Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLoS Comput Biol (2010) 0.90
Mechano-sensitivity of cardiac pacemaker function: pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicity. Prog Biophys Mol Biol (2012) 0.88
Integrative modeling of the cardiac ventricular myocyte. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Images as drivers of progress in cardiac computational modelling. Prog Biophys Mol Biol (2014) 0.82
Synergistic dual automaticity in sinoatrial node cell and tissue models. Circ J (2010) 0.81
Optimisation of ionic models to fit tissue action potentials: application to 3D atrial modelling. Comput Math Methods Med (2013) 0.80
Rabbit models of cardiac mechano-electric and mechano-mechanical coupling. Prog Biophys Mol Biol (2016) 0.80
Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing. PLoS One (2014) 0.79
Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials. Front Physiol (2014) 0.79
Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety? Sci Rep (2016) 0.75
Chronotropic Modulation of the Source-Sink Relationship of Sinoatrial-Atrial Impulse Conduction and Its Significance to Initiation of AF: A One-Dimensional Model Study. Biomed Res Int (2015) 0.75
Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res (2005) 4.79
The CellML Model Repository. Bioinformatics (2008) 2.93
Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res (2004) 2.90
New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation (2007) 2.89
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation (2009) 2.58
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res (2011) 2.41
Generation of histo-anatomically representative models of the individual heart: tools and application. Philos Trans A Math Phys Eng Sci (2009) 2.37
Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. Circ Res (2009) 2.35
Is a scientific boycott ever justified? Nature (2003) 2.18
Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res (2006) 2.17
Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study. Heart Rhythm (2009) 2.05
The funny current has a major pacemaking role in the sinus node. Heart Rhythm (2011) 2.01
Cardiac microstructure: implications for electrical propagation and defibrillation in the heart. Circ Res (2002) 2.00
Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart. Circ Res (2003) 1.90
An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A (2003) 1.86
Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function. Am J Physiol Heart Circ Physiol (2009) 1.84
Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node. Circulation (2007) 1.80
Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel. J Biol Chem (2003) 1.79
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Image-based models of cardiac structure in health and disease. Wiley Interdiscip Rev Syst Biol Med (2010) 1.67
Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Ann N Y Acad Sci (2006) 1.66
CellML and associated tools and techniques. Philos Trans A Math Phys Eng Sci (2008) 1.64
Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ Res (2006) 1.63
Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res (2006) 1.61
Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking. J Physiol (2004) 1.59
CellML metadata standards, associated tools and repositories. Philos Trans A Math Phys Eng Sci (2009) 1.59
Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. Cardiovasc Res (2004) 1.57
Computational physiology and the Physiome Project. Exp Physiol (2004) 1.53
The extent of the specialized atrioventricular ring tissues. Heart Rhythm (2009) 1.53
Left ventricle structural remodelling in the prediabetic Goto-Kakizaki rat. Exp Physiol (2011) 1.51
Myocardial ischemia lowers precordial thump efficacy: an inquiry into mechanisms using three-dimensional simulations. Heart Rhythm (2006) 1.51
FieldML: concepts and implementation. Philos Trans A Math Phys Eng Sci (2009) 1.49
Systems biology and the virtual physiological human. Mol Syst Biol (2009) 1.48
Resolving the M-cell debate: why and how. Heart Rhythm (2011) 1.45
The Cardiac Atlas Project--an imaging database for computational modeling and statistical atlases of the heart. Bioinformatics (2011) 1.44
Sustained inward current and pacemaker activity of mammalian sinoatrial node. J Cardiovasc Electrophysiol (2002) 1.43
Palette of fluorinated voltage-sensitive hemicyanine dyes. Proc Natl Acad Sci U S A (2012) 1.41
3D virtual human atria: A computational platform for studying clinical atrial fibrillation. Prog Biophys Mol Biol (2011) 1.41
The Physiome Model Repository 2. Bioinformatics (2011) 1.40
Effect of adrenergic stimulation on action potential duration restitution in humans. Circulation (2003) 1.39
Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells. J Cardiovasc Electrophysiol (2002) 1.38
A vision and strategy for the virtual physiological human in 2010 and beyond. Philos Trans A Math Phys Eng Sci (2010) 1.33
Micropatterned cell cultures on elastic membranes as an in vitro model of myocardium. Nat Protoc (2006) 1.30
Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development. IEEE Trans Med Imaging (2012) 1.29
Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts. PLoS One (2012) 1.28
Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3. Heart Rhythm (2008) 1.27
Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load. Am J Physiol Heart Circ Physiol (2006) 1.26
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing. Br J Pharmacol (2012) 1.26
The IUPS human Physiome Project. Pflugers Arch (2002) 1.25
Markov models for ion channels: versatility versus identifiability and speed. Philos Trans A Math Phys Eng Sci (2009) 1.25
Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy. Biophys J (2009) 1.25
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers. Circ Res (2012) 1.24
Pacing-induced spontaneous activity in myocardial sleeves of pulmonary veins after treatment with ryanodine. Circulation (2003) 1.24
Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45. Cardiovasc Res (2006) 1.23
The Cardiac Physiome: perspectives for the future. Exp Physiol (2008) 1.22
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res (2010) 1.18
Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria. J Physiol (2013) 1.18
Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol (1985) (2005) 1.18
Single-sensor system for spatially resolved, continuous, and multiparametric optical mapping of cardiac tissue. Heart Rhythm (2011) 1.18
Structural and functional coupling of cardiac myocytes and fibroblasts. Adv Cardiol (2006) 1.18
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node. J Histochem Cytochem (2002) 1.16
Histo-anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI. Prog Biophys Mol Biol (2012) 1.15
Heterogeneous cell coupling in the heart: an electrophysiological role for fibroblasts. Circ Res (2003) 1.15
Contributions of HERG K+ current to repolarization of the human ventricular action potential. Prog Biophys Mol Biol (2007) 1.13
The anatomy and physiology of the sinoatrial node--a contemporary review. Pacing Clin Electrophysiol (2010) 1.12
Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node. Prog Biophys Mol Biol (2007) 1.11
Computer three-dimensional reconstruction of the atrioventricular node. Circ Res (2008) 1.11
High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment. Am J Physiol Heart Circ Physiol (2012) 1.11
Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control. J Physiol (2004) 1.11
Microstructured cocultures of cardiac myocytes and fibroblasts: a two-dimensional in vitro model of cardiac tissue. Microsc Microanal (2005) 1.11
CELLULAR OPEN RESOURCE (COR): current status and future directions. Philos Trans A Math Phys Eng Sci (2009) 1.11
Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells. Biophys J (2010) 1.11
Ageing-related changes of connexins and conduction within the sinoatrial node. J Physiol (2004) 1.10
Toward a VPH/Physiome ToolKit. Wiley Interdiscip Rev Syst Biol Med (2010) 1.10
Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat. Circulation (2006) 1.10
Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node. J Mol Cell Cardiol (2009) 1.09
The anatomy of the cardiac conduction system. Clin Anat (2009) 1.08
Letter by Morris et al regarding article, "Low heart rates predict incident atrial fibrillation in healthy middle-aged men" by Grundvold et al. Circ Arrhythm Electrophysiol (2013) 1.08
Estimating material parameters of a structurally based constitutive relation for skin mechanics. Biomech Model Mechanobiol (2010) 1.08
Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry. Circ Res (2003) 1.08
The use of sparse CT datasets for auto-generating accurate FE models of the femur and pelvis. J Biomech (2006) 1.07
Effect of stretch-activated channels on defibrillation efficacy. Heart Rhythm (2004) 1.06
Cardiac mechano-electric feedback: past, present, and prospect. Prog Biophys Mol Biol (2003) 1.06
Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction. Biophys J (2009) 1.05
Axial stretch enhances sarcoplasmic reticulum Ca2+ leak and cellular Ca2+ reuptake in guinea pig ventricular myocytes: experiments and models. Prog Biophys Mol Biol (2008) 1.04
Mathematical models of the electrical action potential of Purkinje fibre cells. Philos Trans A Math Phys Eng Sci (2009) 1.01
Genotype-Phenotype Map Characteristics of an In silico Heart Cell. Front Physiol (2011) 1.00
Sarcomere length changes in a 3D mathematical model of the pig ventricles. Prog Biophys Mol Biol (2003) 1.00
Role of the 293b-sensitive, slowly activating delayed rectifier potassium current, i(Ks), in pacemaker activity of rabbit isolated sino-atrial node cells. Cardiovasc Res (2002) 1.00
Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval-force relations: a modelling study. Philos Trans A Math Phys Eng Sci (2006) 1.00
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues. Pharmacol Ther (2013) 1.00