Published in Exp Neurol on December 01, 2003
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Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp Neurol (2007) 1.35
ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J (2004) 1.08
Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells. Tissue Eng Part A (2011) 1.01
Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury. Exp Neurol (2011) 1.00
Immature astrocytes promote CNS axonal regeneration when combined with chondroitinase ABC. Dev Neurobiol (2010) 0.99
Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury. Neurobiol Dis (2014) 0.90
Extracellular matrix regulation of inflammation in the healthy and injured spinal cord. Exp Neurol (2014) 0.89
Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat. Surg Neurol (2008) 0.86
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Gene delivery to overcome astrocyte inhibition of axonal growth: an in vitro model of the glial scar. Biotechnol Bioeng (2012) 0.75
Locomotor training restores walking in a nonambulatory child with chronic, severe, incomplete cervical spinal cord injury. Phys Ther (2008) 2.34
Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem (2003) 1.76
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. J Biol Chem (2002) 1.69
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun (2002) 1.55
Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury. Biochem Biophys Res Commun (2005) 1.36
Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats. Exp Neurol (2007) 1.22
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns (2009) 1.21
Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod (2005) 1.20
Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration. Spine (Phila Pa 1976) (2007) 1.15
Effects of trunk restraint combined with intensive task practice on poststroke upper extremity reach and function: a pilot study. Neurorehabil Neural Repair (2008) 1.13
Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum (2005) 1.09
ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J (2004) 1.08
Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis. Arthritis Rheum (2002) 1.04
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem (2002) 1.02
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis. Arthritis Res Ther (2011) 1.02
Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection. J Neurosci (2011) 1.01
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res (2010) 1.01
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. J Biol Chem (2011) 1.01
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension. Exp Neurol (2007) 1.01
Changes in soleus muscle function and fiber morphology with one week of locomotor training in spinal cord contusion injured rats. J Neurotrauma (2006) 1.00
Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycans. J Neurosci Res (2007) 1.00
Disulfide-bonded multimers of proteoglycan 4 PRG4 are present in normal synovial fluids. Biochim Biophys Acta (2009) 1.00
Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. Arthritis Rheum (2002) 0.99
Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury. J Neurosci Res (2006) 0.98
Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin. J Biol Chem (2003) 0.98
Age-related differences in human skin proteoglycans. Glycobiology (2010) 0.96
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochem J (2004) 0.93
Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Eng Part A (2010) 0.92
Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model. J Biomech (2012) 0.91
Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5. J Orthop Res (2011) 0.91
Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts. J Histochem Cytochem (2005) 0.90
Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications. Arthritis Res Ther (2009) 0.90
The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2. Exp Neurol (2005) 0.89
Modular control of varied locomotor tasks in children with incomplete spinal cord injuries. J Neurophysiol (2013) 0.89
Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression. Ann Biomed Eng (2009) 0.88
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism. Arthritis Res Ther (2012) 0.87
Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-alpha-trypsin-inhibitor in equine degenerative suspensory ligament desmitis. J Orthop Res (2011) 0.87
Cell death-associated ADAMTS4 and versican degradation in vascular tissue. J Histochem Cytochem (2009) 0.87
Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties. Matrix Biol (2006) 0.86
Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development. Biochim Biophys Acta (2006) 0.86
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell Tissue Res (2010) 0.85
Changes in muscle T2 relaxation properties following spinal cord injury and locomotor training. Eur J Appl Physiol (2006) 0.84
Recovery of airway protective behaviors after spinal cord injury. Respir Physiol Neurobiol (2009) 0.81
Ongoing walking recovery 2 years after locomotor training in a child with severe incomplete spinal cord injury. Phys Ther (2010) 0.81
Cough following low thoracic hemisection in the cat. Exp Neurol (2010) 0.81
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat. Exp Neurol (2005) 0.80
Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons. Brain Res (2005) 0.79
Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts. Mech Ageing Dev (2006) 0.79
Translational spinal cord injury research: preclinical guidelines and challenges. Handb Clin Neurol (2012) 0.78
Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats. J Neurochem (2004) 0.78
Altered obstacle negotiation after low thoracic hemisection in the cat. J Neurotrauma (2011) 0.77
Arm and leg coordination during treadmill walking in individuals with motor incomplete spinal cord injury: a preliminary study. Gait Posture (2012) 0.77
ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy. J Orthop Res (2013) 0.77
Storage and translational issues in reparative medicine: breakout session summary. Ann N Y Acad Sci (2002) 0.75
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Image analysis of aggrecan degradation in articular cartilage with formalin-fixed samples. Methods Mol Med (2007) 0.75