Published in Nat Med on February 08, 2004
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer (2009) 2.18
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A (2005) 1.61
Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. J Neurosci (2009) 1.54
Gq signaling causes glomerular injury by activating TRPC6. J Clin Invest (2015) 1.54
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A (2006) 1.54
Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm (2010) 1.49
NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation. Gene (2006) 1.28
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2012) 1.11
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. J Virol (2012) 1.10
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun Signal (2009) 1.06
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J Immunol (2007) 1.06
Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis. PLoS One (2011) 1.05
Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis. Proc Natl Acad Sci U S A (2008) 1.03
TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J Clin Invest (2006) 1.03
The calcineurin-NFAT pathway allows for urokinase receptor-mediated beta3 integrin signaling to cause podocyte injury. J Mol Med (Berl) (2012) 1.02
Involvement of oxidative stress and the JNK pathway in glucose toxicity. Rev Diabet Stud (2005) 1.01
Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1. J Biol Chem (2012) 1.01
Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. Mol Endocrinol (2011) 1.00
Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells). J Neurosci (2010) 1.00
Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J Biol Chem (2009) 0.99
High-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction. ACS Comb Sci (2011) 0.99
High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor. J Biol Chem (2011) 0.97
Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. Oncotarget (2015) 0.96
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One (2012) 0.92
Calcium-dependent transcription of cytokine genes in T lymphocytes. Pflugers Arch (2007) 0.91
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem (2010) 0.88
Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1. Hepatology (2011) 0.88
Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. Cell Signal (2011) 0.88
Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood (2015) 0.87
Osteopontin signals through calcium and nuclear factor of activated T cells (NFAT) in osteoclasts: a novel RGD-dependent pathway promoting cell survival. J Biol Chem (2011) 0.87
NFATs and Alzheimer's Disease. Mol Cell Pharmacol (2010) 0.87
Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions. Cell Commun Signal (2014) 0.87
In vivo significance of ITK-SLP-76 interaction in cytokine production. Mol Cell Biol (2010) 0.86
Transcriptional regulation of BK virus by nuclear factor of activated T cells. J Virol (2009) 0.84
Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients. PLoS Pathog (2013) 0.83
Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy. Am J Physiol Renal Physiol (2015) 0.83
Identification of a novel cell-penetrating peptide from human phosphatidate phosphatase LPIN3. Mol Cells (2012) 0.83
Comparison of Incubation Solutions Prior to the Purification of Porcine Islet Cells. Cell Med (2013) 0.82
Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther (2013) 0.82
Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease. Adv Exp Med Biol (2008) 0.82
Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes. PLoS One (2011) 0.82
A Combined Continuous Density/Osmolality Gradient for Supplemental Purification of Human Islets. Cell Med (2012) 0.82
The glutamatergic aspects of schizophrenia molecular pathophysiology: role of the postsynaptic density, and implications for treatment. Curr Neuropharmacol (2014) 0.82
Non-immunologic actions of calcineurin inhibitors in proteinuric kidney diseases. Front Endocrinol (Lausanne) (2014) 0.81
Functional cell permeable motifs within medically relevant proteins. J Biotechnol (2007) 0.81
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med (2015) 0.81
Recent progress in pancreatic islet transplantation. World J Transplant (2011) 0.81
Interplay of T-cell receptor and interleukin-2 signalling in Vγ2Vδ2 T-cell cytotoxicity. Immunology (2010) 0.80
ISL1 protein transduction promotes cardiomyocyte differentiation from human embryonic stem cells. PLoS One (2013) 0.80
The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun (2014) 0.80
Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells. Bone (2009) 0.80
Comparison of New Preservation Solutions, HN-1 and University of Wisconsin Solution, in Pancreas Preservation for Porcine Islet Isolation. Cell Med (2013) 0.79
In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle. PLoS One (2013) 0.78
Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.78
COPA and SLC4A4 are required for cellular entry of arginine-rich peptides. PLoS One (2014) 0.78
Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide. PLoS One (2013) 0.77
Pancreas procurement and preservation for islet transplantation: personal considerations. J Transplant (2011) 0.77
Calcineurin/NFAT signaling represses genes Vamp1 and Vamp2 via PMCA-dependent mechanism during dopamine secretion by Pheochromocytoma cells. PLoS One (2014) 0.77
Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation. J Vasc Res (2016) 0.76
Isolation Efficiency of Mouse Pancreatic Stem Cells Is Age Dependent. Cell Med (2013) 0.75
Novel Positive-Charged Nanoparticles for Efficient Magnetic Resonance Imaging of Islet Transplantation. Cell Med (2012) 0.75
The Evaluation of Islet Purification Methods That Use Large Bottles to Create a Continuous Density Gradient. Cell Med (2016) 0.75
Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. J Neuroinflammation (2015) 0.75
Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction. J Med Chem (2014) 0.75
Comparison of Purification Solutions With Different Osmolality for Porcine Islet Purification. Cell Med (2016) 0.75
Culture Conditions for Mouse Pancreatic Stem Cells. Cell Med (2013) 0.75
Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose. PLoS One (2016) 0.75
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med (2010) 7.11
Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med (2005) 4.31
Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology (2008) 3.99
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62
Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J Natl Cancer Inst (2009) 2.57
Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant (2010) 2.50
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature (2007) 2.47
In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci U S A (2009) 2.46
Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet (2005) 2.39
Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys (2003) 2.34
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus. Nat Med (2006) 2.27
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. J Clin Oncol (2004) 2.27
Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes. Nat Biotechnol (2006) 2.21
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Nat Neurosci (2003) 2.17
A human beta-cell line for transplantation therapy to control type 1 diabetes. Nat Biotechnol (2005) 2.12
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat Cell Biol (2011) 2.06
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest (2011) 1.80
Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle (2011) 1.76
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles. J Cell Biol (2003) 1.65
Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice. J Hepatol (2009) 1.64
Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci (2002) 1.64
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. J Biol Chem (2005) 1.64
Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Mol Cancer Ther (2009) 1.61
An assessment of the feasibility of sentinel lymph node-guided surgery for gastric cancer. Gastric Cancer (2004) 1.61
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem (2005) 1.57
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol (2005) 1.55
Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration. J Biol Chem (2003) 1.55
Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun (2007) 1.52
Human monocyte-derived dendritic cells pulsed with wild-type p53 protein efficiently induce CTLs against p53 overexpressing human cancer cells. Clin Cancer Res (2005) 1.50
Fluorescent cocaine probes: a tool for the selection and engineering of therapeutic antibodies. J Am Chem Soc (2005) 1.48
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. J Biol Chem (2010) 1.47
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload. Gen Thorac Cardiovasc Surg (2010) 1.46
Metre-long cell-laden microfibres exhibit tissue morphologies and functions. Nat Mater (2013) 1.44
Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology (2008) 1.43
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A (2004) 1.37
A simple biological imaging system for detecting viable human circulating tumor cells. J Clin Invest (2009) 1.36
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology (2008) 1.34
The outcome of living donor liver transplantation with prior spontaneous large portasystemic shunts. Transpl Int (2007) 1.32
Telomerase-specific replication-selective virotherapy for human cancer. Clin Cancer Res (2004) 1.32
Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells. Int J Mol Med (2004) 1.30
Synthesis and biological validation of a ubiquitous quorum-sensing molecule. Angew Chem Int Ed Engl (2004) 1.29
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices. J Med Chem (2004) 1.29
Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy. Int J Cancer (2006) 1.27
Successful islet transplantation from nonheartbeating donor pancreata using modified Ricordi islet isolation method. Transplantation (2006) 1.26
Interaction of synaptic scaffolding molecule and Beta -catenin. J Neurosci (2002) 1.26
Role of inherited defects of MYH in the development of sporadic colorectal cancer. Genes Chromosomes Cancer (2004) 1.26
Heparanase expression correlates with invasion and poor prognosis in gastric cancers. Lab Invest (2003) 1.25
Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring. Proc Natl Acad Sci U S A (2010) 1.24
Visualization of intrathoracically disseminated solid tumors in mice with optical imaging by telomerase-specific amplification of a transferred green fluorescent protein gene. Cancer Res (2004) 1.22
Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines. Nat Protoc (2007) 1.22
Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases. Clin Cancer Res (2003) 1.22
Long-term in vivo glucose monitoring using fluorescent hydrogel fibers. Proc Natl Acad Sci U S A (2011) 1.22
Seven consecutive successful clinical islet isolations with pancreatic ductal injection. Cell Transplant (2009) 1.21
Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons. J Biol Chem (2005) 1.21
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J Neurochem (2005) 1.20
Large human islets secrete less insulin per islet equivalent than smaller islets in vitro. Islets (2011) 1.20
The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction. J Biol Chem (2004) 1.19
E-prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization. J Pharmacol Exp Ther (2004) 1.17
Ductal injection of preservation solution increases islet yields in islet isolation and improves islet graft function. Cell Transplant (2008) 1.16
SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes. Diabetes Res Clin Pract (2006) 1.16
Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer (2008) 1.15
A genetic variant of the serine racemase gene is associated with schizophrenia. Biol Psychiatry (2006) 1.14
Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells. Biochem Biophys Res Commun (2005) 1.12
Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT. Transplantation (2004) 1.12