Published in J Infect Dis on February 02, 2004
Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan. J Clin Microbiol (2005) 1.72
Helicobacter pylori and gastric carcinogenesis. J Gastroenterol (2009) 1.54
Helicobacter pylori virulence factors in gastric carcinogenesis. Cancer Lett (2008) 1.29
Simple method for determination of the number of Helicobacter pylori CagA variable-region EPIYA tyrosine phosphorylation motifs by PCR. J Clin Microbiol (2005) 1.28
Polymorphism in the CagA EPIYA motif impacts development of gastric cancer. J Clin Microbiol (2009) 1.27
Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer. J Clin Microbiol (2009) 1.25
Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan. J Gastroenterol (2006) 1.16
Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses. J Bacteriol (2010) 1.10
Strategy to characterize the number and type of repeating EPIYA phosphorylation motifs in the carboxyl terminus of CagA protein in Helicobacter pylori clinical isolates. J Clin Microbiol (2006) 1.07
H pylori and gastric cancer: shifting the global burden. World J Gastroenterol (2006) 1.05
Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer. BMC Microbiol (2011) 1.05
Chromosome painting in silico in a bacterial species reveals fine population structure. Mol Biol Evol (2013) 1.05
Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagA. J Biol Chem (2009) 1.03
Helicobacter pylori and gastroduodenal pathology: new threats of the old friend. Ann Clin Microbiol Antimicrob (2005) 1.02
Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world. J Clin Microbiol (2010) 1.01
A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol (2010) 1.00
Helicobacter pylori homB, but not cagA, is associated with gastric cancer in Iran. J Clin Microbiol (2011) 0.99
Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene. Infect Immun (2007) 0.99
Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis. World J Gastroenterol (2010) 0.99
Intact long-type dupA as a marker for gastroduodenal diseases in Okinawan subpopulation, Japan. Helicobacter (2012) 0.97
Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication. J Gastroenterol (2011) 0.96
Analysis of virulence factors of Helicobacter pylori isolated from a Vietnamese population. BMC Microbiol (2009) 0.94
Analysis of the 3' variable region of the cagA gene of Helicobacter pylori isolated in Koreans. Dig Dis Sci (2007) 0.93
Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. Eur J Clin Microbiol Infect Dis (2009) 0.91
Host factors are important in determining clinical outcomes of Helicobacter pylori infection. J Gastroenterol (2006) 0.91
J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution. J Bacteriol (2012) 0.90
Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease. Gut Microbes (2013) 0.89
CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease. J Clin Microbiol (2010) 0.88
Potentiation of Helicobacter pylori CagA protein virulence through homodimerization. J Biol Chem (2011) 0.88
A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions. PLoS Pathog (2015) 0.88
Helicobacter pylori Diversity and Gastric Cancer Risk. MBio (2016) 0.88
Helicobacter pylori initiates a mesenchymal transition through ZEB1 in gastric epithelial cells. PLoS One (2013) 0.87
Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence. Helicobacter (2012) 0.87
Tyrosine phosphorylation of CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelial cells. J Clin Microbiol (2005) 0.87
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. World J Gastroenterol (2015) 0.87
Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms. World J Gastroenterol (2006) 0.86
Causal role of Helicobacter pylori infection in gastric cancer. World J Gastroenterol (2006) 0.84
The Relationship between H. pylori Infection and Osteoporosis in Japan. Gastroenterol Res Pract (2014) 0.84
Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer. World J Gastroenterol (2013) 0.84
Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese. BMC Gastroenterol (2009) 0.84
Latest insights into the effects of Helicobacter pylori infection on gastric carcinogenesis. World J Gastroenterol (2006) 0.83
Analysis of clarithromycin resistance and CagA status in Helicobacter pylori by use of feces from children in Thailand. J Clin Microbiol (2009) 0.83
Evaluation of the anti-East Asian CagA-specific antibody for CagA phenotyping. Clin Vaccine Immunol (2009) 0.83
Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients. HPB (Oxford) (2012) 0.81
Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians. Gastric Cancer (2006) 0.81
Helicobacter pylori strain-specific modulation of gastric inflammation in Mongolian gerbils. World J Gastroenterol (2005) 0.80
Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein. Sci Rep (2015) 0.79
Phylogenetic analysis, based on EPIYA repeats in the cagA gene of Indian Helicobacter pylori, and the implications of sequence variation in tyrosine phosphorylation motifs on determining the clinical outcome. Genet Mol Biol (2011) 0.79
Distinct repeat motifs at the C-terminal region of CagA of Helicobacter pylori strains isolated from diseased patients and asymptomatic individuals in West Bengal, India. Gut Pathog (2012) 0.77
Expression of MicroRNA in Host Cells Infected with Helicobacter pylori. Gut Liver (2017) 0.77
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract. Cell Mol Gastroenterol Hepatol (2015) 0.76
Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b. Sci Rep (2016) 0.76
Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia. Sci Rep (2014) 0.75
Differences in amino acid frequency in CagA and VacA sequences of Helicobacter pylori distinguish gastric cancer from gastric MALT lymphoma. Gut Pathog (2016) 0.75
Helicobacter pylori Infection in Gastroesophageal Reflux Disease in the Asian Countries. Gastroenterol Res Pract (2015) 0.75
No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study. Springerplus (2015) 0.75
Gastric mucosa in Mongolian and Japanese patients with gastric cancer and Helicobacter pylori infection. World J Gastroenterol (2015) 0.75
Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. Gastric Cancer (2010) 0.75
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science (2001) 5.49
Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A (2005) 3.52
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A (2002) 3.50
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem (2002) 2.23
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem (2004) 2.01
Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein. Cell Host Microbe (2010) 1.93
Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology (2006) 1.77
Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA. Cell Host Microbe (2012) 1.72
Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan. J Clin Microbiol (2005) 1.72
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep (2009) 1.63
Transposable element ISHp608 of Helicobacter pylori: nonrandom geographic distribution, functional organization, and insertion specificity. J Bacteriol (2002) 1.60
Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis. Cancer Sci (2005) 1.59
Fulminant varicella infection complicated with acute respiratory distress syndrome, and disseminated intravascular coagulation in an immunocompetent young adult. Intern Med (2004) 1.54
Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe (2012) 1.49
Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan. J Infect Dis (2002) 1.46
Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol (2006) 1.43
3D-CT evaluation of facial asymmetry in patients with maxillofacial deformities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2006) 1.39
Colonization dynamics of altered Schaedler flora is influenced by gender, aging, and Helicobacter hepaticus infection in the intestines of Swiss Webster mice. Appl Environ Microbiol (2006) 1.29
EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells. J Biol Chem (2005) 1.27
Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma. Oncogene (2003) 1.25
Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells. J Biol Chem (2006) 1.23
Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J Biol Chem (2008) 1.17
Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan. J Gastroenterol (2006) 1.16
Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. J Exp Med (2010) 1.15
Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol (2010) 1.14
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. J Infect Dis (2002) 1.13
Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan. J Clin Microbiol (2004) 1.12
Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA. Cancer Sci (2008) 1.11
Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice. Int J Cancer (2009) 1.09
Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc Natl Acad Sci U S A (2005) 1.08
Regulation of human T-cell leukemia virus type 1 (HTLV-1) budding by ubiquitin ligase Nedd4. Microbes Infect (2004) 1.07
Intraductal mucinous tumors occurring simultaneously in the liver and pancreas. J Gastroenterol (2002) 1.05
SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. Mol Cell (2011) 1.03
Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. Cancer Sci (2004) 1.03
Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagA. J Biol Chem (2009) 1.03
Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence. Int J Cancer (2008) 1.03
Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure. Cell Microbiol (2006) 1.03
The diversity of vacA and cagA genes of Helicobacter pylori in East Asia. FEMS Immunol Med Microbiol (2004) 1.00
Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Proc Natl Acad Sci U S A (2011) 0.99
Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. PLoS Comput Biol (2007) 0.99