Published in J Cell Sci on March 01, 2004
Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell (2005) 7.27
The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol (2010) 1.77
MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol (2008) 1.75
c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol (2007) 1.46
Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci U S A (2010) 1.27
VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat Immunol (2013) 1.21
Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse. J Exp Med (2013) 1.12
Immune synapse: conductor of orchestrated organelle movement. Trends Cell Biol (2013) 1.05
Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system. J Cell Sci (2014) 1.05
End-binding protein 1 controls signal propagation from the T cell receptor. EMBO J (2012) 1.04
Real-time cross-correlation image analysis of early events in IgE receptor signaling. Biophys J (2008) 1.02
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. J Immunol (2009) 1.00
Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. J Immunol (2013) 0.99
Endocytic events in TCR signaling: focus on adapters in microclusters. Immunol Rev (2009) 0.96
Examining multiprotein signaling complexes from all angles. FEBS J (2005) 0.94
ZAP70: a master regulator of adaptive immunity. Semin Immunopathol (2010) 0.93
An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes. J Exp Med (2008) 0.93
Signaling-dependent immobilization of acylated proteins in the inner monolayer of the plasma membrane. J Cell Biol (2006) 0.92
Communication, the centrosome and the immunological synapse. Philos Trans R Soc Lond B Biol Sci (2014) 0.87
How membrane structures control T cell signaling. Front Immunol (2012) 0.86
Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice. J Nutr (2009) 0.81
IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo. Proc Natl Acad Sci U S A (2015) 0.78
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis. Cell Death Differ (2015) 0.78
Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells. Int Immunol (2016) 0.77
WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site. J Biol Chem (2014) 0.77
Orchestrating Lymphocyte Polarity in Cognate Immune Cell-Cell Interactions. Int Rev Cell Mol Biol (2016) 0.76
Signaling at the immune synapse: vesicular trafficking takes the stage. Cell Mol Immunol (2013) 0.75
Analyzing the homeostasis of signaling proteins by a combination of Western blot and fluorescence correlation spectroscopy. Biophys J (2011) 0.75
The T cell IFT20 interactome reveals new players in immune synapse assembly. J Cell Sci (2017) 0.75
3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse. Sci Rep (2017) 0.75
New Insights into How Trafficking Regulates T Cell Receptor Signaling. Front Cell Dev Biol (2016) 0.75
Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set. Front Immunol (2016) 0.75
A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse. Bioarchitecture (2015) 0.75
Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res (2009) 3.31
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J Immunol (2002) 3.28
Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J Cell Biol (2002) 3.16
Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork. EMBO J (2006) 2.87
STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med (2009) 2.72
Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. Blood (2012) 2.57
CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51
Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Invest (2011) 2.44
PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. Cancer Res (2012) 2.43
Copper-mediated coupling reactions and their applications in natural products and designed biomolecules synthesis. Chem Rev (2008) 2.35
Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies. Hum Mol Genet (2004) 2.31
CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res (2011) 2.26
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection. PLoS One (2009) 2.23
Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood (2002) 2.21
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. Nat Chem Biol (2008) 2.12
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol (2008) 2.12
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J Allergy Clin Immunol (2009) 2.09
Dynamics in the plasma membrane: how to combine fluidity and order. EMBO J (2006) 2.03
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science (2002) 2.01
Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science (2012) 1.98
Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cells. Eur J Immunol (2004) 1.92
Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes. Eur J Immunol (2009) 1.92
PD-L2 is expressed on activated human T cells and regulates their function. Mol Immunol (2011) 1.79
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol (2008) 1.78
TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J (2002) 1.75
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med (2002) 1.74
Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood (2008) 1.74
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest (2009) 1.71
ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation. EMBO J (2007) 1.68
A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood (2012) 1.68
The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells. Blood (2013) 1.65
Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat Immunol (2006) 1.64
Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells. Cell (2011) 1.55
Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med (2006) 1.54
Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes. J Immunol (2004) 1.49
Force generation upon T cell receptor engagement. PLoS One (2011) 1.49
Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes. Immunity (2008) 1.48
Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4+ T-lymphocyte subset in normal and mycosis fungoides skin. Cytometry A (2014) 1.48
Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med (2004) 1.47
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep (2002) 1.44
ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. Immunity (2006) 1.43
Multiplicity and plasticity of natural killer cell signaling pathways. Blood (2005) 1.40
In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Immunity (2002) 1.39
Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med (2012) 1.39
CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers. J Immunol (2007) 1.35
Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages. Eur J Immunol (2008) 1.34
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A (2007) 1.34
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J Biol Chem (2012) 1.34
Palmitoylation is required for efficient Fas cell death signaling. EMBO J (2006) 1.33
MAIT cells detect and efficiently lyse bacterially-infected epithelial cells. PLoS Pathog (2013) 1.32
Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function. Hum Immunol (2004) 1.32
LAT regulates gammadelta T cell homeostasis and differentiation. Nat Immunol (2003) 1.29
HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. J Virol (2009) 1.28
CD molecules 2005: human cell differentiation molecules. Blood (2005) 1.27
Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem (2009) 1.27
Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol (2010) 1.25
IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities. J Immunol (2003) 1.23
ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells. Cancer Res (2012) 1.22
Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments. Cytometry A (2015) 1.21
VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat Immunol (2013) 1.21
Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment. Eur J Immunol (2011) 1.19
Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol (2007) 1.19
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes. EMBO J (2006) 1.18
A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. J Biol Chem (2002) 1.17
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med (2009) 1.17
Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity. Eur J Immunol (2009) 1.16
The co-expression of 2B4 (CD244) and CD160 delineates a subpopulation of human CD8+ T cells with a potent CD160-mediated cytolytic effector function. Eur J Immunol (2006) 1.15
ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol (2008) 1.14
A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes. Eur J Immunol (2002) 1.14
PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1. Int Immunol (2010) 1.13
Role of ICAM-3 in the initial interaction of T lymphocytes and APCs. Nat Immunol (2002) 1.13
A co-evolution perspective of the TNFSF and TNFRSF families in the immune system. Trends Immunol (2003) 1.12
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. Eur J Immunol (2011) 1.11
The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression. Clin Cancer Res (2013) 1.10
Human breast tumor cells induce self-tolerance mechanisms to avoid NKG2D-mediated and DNAM-mediated NK cell recognition. Cancer Res (2011) 1.09
High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma. Int J Cancer (2012) 1.08
CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer. Cancer Res (2013) 1.07
Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling. PLoS One (2008) 1.07
All-trans retinoic acid skews monocyte differentiation into interleukin-12-secreting dendritic-like cells. Br J Haematol (2003) 1.07
High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Am J Clin Pathol (2009) 1.07
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. Blood (2007) 1.06
Human Vγ9Vδ2 T cells specifically recognize and kill acute myeloid leukemic blasts. J Immunol (2012) 1.06
Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J Immunol (2009) 1.06
Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum Pathol (2008) 1.06
Coronin-1 expression in T lymphocytes: insights into protein function during T cell development and activation. Int Immunol (2004) 1.05