Published in Neuron on March 04, 2004
4-Aminopyridine in Episodic Ataxia Type 2 (4AP in EA2) | NCT01543750
Coding of facial expressions of pain in the laboratory mouse. Nat Methods (2010) 4.47
Inherited neuronal ion channelopathies: new windows on complex neurological diseases. J Neurosci (2008) 2.04
Molecular genetics of migraine. Hum Genet (2009) 1.91
Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest (2008) 1.81
Casein kinase iδ mutations in familial migraine and advanced sleep phase. Sci Transl Med (2013) 1.65
CaV2.1 channelopathies. Pflugers Arch (2010) 1.58
Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept. Cephalalgia (2012) 1.48
Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A (2016) 1.39
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Pain as a channelopathy. J Clin Invest (2010) 1.33
Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation (2011) 1.28
Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS. Nat Rev Neurol (2012) 1.28
The primary headaches: genetics, epigenetics and a behavioural genetic model. J Headache Pain (2008) 1.21
Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci (2014) 1.20
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet (2011) 1.16
Cortical spreading depression and migraine. Nat Rev Neurol (2013) 1.15
Pathophysiology of migraine. Ann Indian Acad Neurol (2012) 1.14
Divergent sodium channel defects in familial hemiplegic migraine. Proc Natl Acad Sci U S A (2008) 1.13
Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission. Proc Natl Acad Sci U S A (2005) 1.13
Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. J Physiol (2010) 1.11
Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci (2008) 1.10
Pain channelopathies. J Physiol (2010) 1.09
Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. J Neurosci (2011) 1.07
The impact of anesthetics and hyperoxia on cortical spreading depression. Exp Neurol (2008) 1.05
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Mol Pain (2008) 1.05
Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia (2010) 1.05
Identification of molecular genetic factors that influence migraine. Mol Genet Genomics (2011) 1.04
Pathophysiologic cascades in ischemic stroke. Int J Stroke (2012) 1.03
Cortical spreading depression as a target for anti-migraine agents. J Headache Pain (2013) 1.03
The differential expression of low-threshold K+ currents generates distinct firing patterns in different subtypes of adult mouse trigeminal ganglion neurones. J Physiol (2008) 1.03
Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits. J Gen Physiol (2004) 1.02
Benign paroxysmal tonic upgaze, benign paroxysmal torticollis, episodic ataxia and CACNA1A mutation in a family. J Neurol (2008) 1.00
The cerebellum and migraine. Headache (2007) 1.00
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev (2015) 0.99
Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel. J Neurosci (2008) 0.98
Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain. Mol Pain (2010) 0.98
Pathophysiological role of omega pore current in channelopathies. Front Pharmacol (2012) 0.97
Gain of function in FHM-1 Cav2.1 knock-in mice is related to the shape of the action potential. J Neurophysiol (2010) 0.95
Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. Stroke (2014) 0.95
Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine. J Physiol (2011) 0.95
Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies. Neuroscience (2008) 0.95
Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice. PLoS One (2013) 0.95
Studies on the pathophysiology and genetic basis of migraine. Curr Genomics (2013) 0.94
Epigenetic mechanisms in migraine: a promising avenue? BMC Med (2013) 0.93
Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel. Proc Natl Acad Sci U S A (2010) 0.93
Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol (2009) 0.93
TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. PLoS One (2013) 0.93
Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem (2009) 0.93
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain (2013) 0.93
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Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model. Mol Pain (2011) 0.92
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Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons. J Neurophysiol (2011) 0.90
Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. J Neurosci (2014) 0.89
Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine. BMC Neurosci (2012) 0.89
The S218L familial hemiplegic migraine mutation promotes deinhibition of Ca(v)2.1 calcium channels during direct G-protein regulation. Pflugers Arch (2008) 0.89
Child neurology: Migraine with aura in children. Neurology (2010) 0.87
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Modelling headache and migraine and its pharmacological manipulation. Br J Pharmacol (2014) 0.86
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New ataxic tottering-6j mouse allele containing a Cacna1a gene mutation. PLoS One (2012) 0.85
Effects of LPS on P2X3 receptors of trigeminal sensory neurons and macrophages from mice expressing the R192Q Cacna1a gene mutation of familial hemiplegic migraine-1. Purinergic Signal (2012) 0.85
P/Q-type calcium channel modulators. Br J Pharmacol (2012) 0.84
Modal gating of human CaV2.1 (P/Q-type) calcium channels: II. the b mode and reversible uncoupling of inactivation. J Gen Physiol (2004) 0.83
Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies. Mol Genet Genomic Med (2013) 0.83
A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis. Proc Natl Acad Sci U S A (2010) 0.83
Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice. Sleep (2013) 0.83
Deciphering migraine. J Clin Invest (2009) 0.83
Stabilization of Ca current in Purkinje neurons during high-frequency firing by a balance of Ca-dependent facilitation and inactivation. Channels (Austin) (2009) 0.82
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. Sci Rep (2016) 0.82
The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1). PLoS One (2013) 0.82
The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition. Pflugers Arch (2009) 0.82
Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice. Neurobiol Dis (2014) 0.82
Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev (2017) 0.81
The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases. Curr Neuropharmacol (2013) 0.80
Presynaptic CaV2.1 calcium channels carrying familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held. J Neurophysiol (2012) 0.80
ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease. Front Physiol (2016) 0.80
A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx. PLoS One (2015) 0.79
Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²⁺ channel due to a familial hemiplegic migraine mutation. Neuron (2014) 0.79
Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons. J Neurophysiol (2014) 0.79
Dystonia and cerebellar degeneration in the leaner mouse mutant. Brain Res (2015) 0.79
The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings. Cerebellum (2009) 0.79
Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans. Front Cell Neurosci (2015) 0.78
Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci (2015) 0.78
In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures. Proc Natl Acad Sci U S A (2017) 0.78
Large-scale mass spectrometry imaging investigation of consequences of cortical spreading depression in a transgenic mouse model of migraine. J Am Soc Mass Spectrom (2015) 0.78
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Ann Neurol (2015) 0.78
Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine. Mol Neurobiol (2016) 0.78
Spreading depression transiently disrupts myelin via interferon-gamma signaling. Exp Neurol (2014) 0.78
Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas. Hum Genet (2016) 0.78
Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression. Br J Pharmacol (2012) 0.77
The first phase of a migraine attack resides in the cortex. J Neural Transm (Vienna) (2012) 0.76
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One case of sporadic hemiplegic migraine with multiple pulmonary arteriovenous malformation. J Headache Pain (2011) 0.75
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. EMBO Mol Med (2016) 0.75
Migraine aura: a knockin mouse with a knockout message. Neuron (2004) 0.75
Migraine--current understanding and treatment. N Engl J Med (2002) 9.80
Migraine as a risk factor for subclinical brain lesions. JAMA (2004) 5.02
A unifying genetic model for facioscapulohumeral muscular dystrophy. Science (2010) 4.87
Coding of facial expressions of pain in the laboratory mouse. Nat Methods (2010) 4.47
Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy. Nat Genet (2003) 3.60
Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet (2005) 3.27
Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet (2009) 2.90
Common epigenetic changes of D4Z4 in contraction-dependent and contraction-independent FSHD. Hum Mutat (2009) 2.84
Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2. Nat Genet (2012) 2.82
Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model. Brain (2008) 2.60
Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. Brain (2005) 2.59
Specific sequence variations within the 4q35 region are associated with facioscapulohumeral muscular dystrophy. Am J Hum Genet (2007) 2.54
Structural brain changes in migraine. JAMA (2012) 2.47
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility. J Immunol (2011) 2.44
Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere. Nat Genet (2002) 2.42
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet (2007) 2.35
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet (2010) 2.35
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood. Nat Genet (2012) 2.34
Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol (2006) 2.31
Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome. Eur J Pain (2009) 2.12
Inherited neuronal ion channelopathies: new windows on complex neurological diseases. J Neurosci (2008) 2.04
Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet (2011) 1.98
Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron (2009) 1.97
Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases. Arch Neurol (2007) 1.95
Molecular genetics of migraine. Hum Genet (2009) 1.91
Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity. J Neurosci (2010) 1.87
Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest (2008) 1.81
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis (2009) 1.78
Genetic inflammatory factors predict restenosis after percutaneous coronary interventions. Circulation (2005) 1.78
Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. Genomics (2002) 1.75
Contractions of D4Z4 on 4qB subtelomeres do not cause facioscapulohumeral muscular dystrophy. Am J Hum Genet (2004) 1.72
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A (2002) 1.64
Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet (2012) 1.64
Smartphones in ophthalmology. Indian J Ophthalmol (2012) 1.64
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain (2010) 1.63
Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Ann Neurol (2003) 1.51
Anatomical variations in the circle of Willis and migraine susceptibility: is there an association? Headache (2009) 1.51
Migraine is not associated with enhanced atherosclerosis. Cephalalgia (2012) 1.49
Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. Neuron (2007) 1.49
Worldwide population analysis of the 4q and 10q subtelomeres identifies only four discrete interchromosomal sequence transfers in human evolution. Am J Hum Genet (2010) 1.48
Molecular basis of plasticity in the visual cortex. Trends Neurosci (2003) 1.46
Variable hypomethylation of D4Z4 in facioscapulohumeral muscular dystrophy. Ann Neurol (2005) 1.46
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AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration. FASEB J (2006) 1.44
Extracellular matrix and visual cortical plasticity: freeing the synapse. Neuron (2004) 1.43
Migraine: a disorder of brain excitatory-inhibitory balance? Trends Neurosci (2012) 1.42
Frontal lobe structure and executive function in migraine patients. Neurosci Lett (2008) 1.42
Facioscapulohumeral muscular dystrophy. Biochim Biophys Acta (2006) 1.41
Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. Hum Mol Genet (2011) 1.39
Attack frequency and disease duration as indicators for brain damage in migraine. Headache (2008) 1.37
Early environmental enrichment moderates the behavioral and synaptic phenotype of MeCP2 null mice. Biol Psychiatry (2010) 1.36
Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size. Proc Natl Acad Sci U S A (2006) 1.35
Brain stem and cerebellar hyperintense lesions in migraine. Stroke (2006) 1.34
Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families. Clin Cancer Res (2008) 1.32
Experience-dependent expression of miR-132 regulates ocular dominance plasticity. Nat Neurosci (2011) 1.32
Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study. Neurol Sci (2010) 1.28
Cutaneous allodynia as a predictor of migraine chronification. Brain (2013) 1.28
Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation (2011) 1.28
High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol (2010) 1.27
Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proc Natl Acad Sci U S A (2011) 1.26
Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Am J Hum Genet (2011) 1.24
A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine. J Headache Pain (2011) 1.22
Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits. Diabetes Care (2010) 1.21
Patterned vision causes CRE-mediated gene expression in the visual cortex through PKA and ERK. J Neurosci (2003) 1.21
A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine. J Headache Pain (2010) 1.21
Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biol Psychiatry (2009) 1.21
Migraine: gene mutations and functional consequences. Curr Opin Neurol (2007) 1.20
Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD. PLoS Genet (2013) 1.19
Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice. Brain (2012) 1.19
Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake. Arch Neurol (2009) 1.18
A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum Mol Genet (2008) 1.17
Current PTCA practice and clinical outcomes in The Netherlands: the real world in the pre-drug-eluting stent era. Eur Heart J (2004) 1.16
Tumor necrosis factor-alpha plays an important role in restenosis development. FASEB J (2005) 1.16
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet (2011) 1.16
Protein studies in dysferlinopathy patients using llama-derived antibody fragments selected by phage display. Eur J Hum Genet (2005) 1.15
Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. Acta Neuropathol (2003) 1.14
Mechanism and timing of mitotic rearrangements in the subtelomeric D4Z4 repeat involved in facioscapulohumeral muscular dystrophy. Am J Hum Genet (2004) 1.13
Divergent sodium channel defects in familial hemiplegic migraine. Proc Natl Acad Sci U S A (2008) 1.13
Alpha-1 antitrypsin Null mutations and severity of emphysema. Respir Med (2008) 1.12
Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle. Hum Mol Genet (2008) 1.12