The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.

Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies. Cancer Cell (2014) 1.55

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity. J Exp Med (2012) 1.55

Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity (2012) 1.30

Germinal centers and autoimmune disease in humans and mice. Immunol Cell Biol (2016) 1.08

Antigen cross-presentation of immune complexes. Front Immunol (2014) 0.99

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nat Med (2014) 0.96

Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity. Mol Immunol (2012) 0.95

Regulation of allograft survival by inhibitory FcγRIIb signaling. J Immunol (2012) 0.94

SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development. PLoS One (2012) 0.94

B Cell in Autoimmune Diseases. Scientifica (Cairo) (2012) 0.90

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN. J Am Soc Nephrol (2013) 0.89

Inhibitory Fcγ receptor is required for the maintenance of tolerance through distinct mechanisms. J Immunol (2014) 0.85

Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques. J Am Heart Assoc (2014) 0.85

Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice. Int Immunol (2014) 0.84

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol (2012) 0.84

Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility. Immunol Lett (2012) 0.84

Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity. Int Immunol (2013) 0.83

The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS One (2015) 0.82

Recovery of an antiviral antibody response following attrition caused by unrelated infection. PLoS Pathog (2014) 0.81

Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression. Genes Immun (2015) 0.81

Lupus Nephritis: Animal Modeling of a Complex Disease Syndrome Pathology. Drug Discov Today Dis Models (2014) 0.78

Comment on "The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility". J Immunol (2011) 0.77

Reduced Atherosclerosis in apoE-inhibitory FcγRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages. Arterioscler Thromb Vasc Biol (2015) 0.77

Targeting B cells and autoantibodies in the therapy of autoimmune diseases. Semin Immunopathol (2014) 0.77

Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity. Rambam Maimonides Med J (2015) 0.77

Strain-specific modifier genes governing craniofacial phenotypes. Birth Defects Res A Clin Mol Teratol (2012) 0.76

Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis. BMC Immunol (2014) 0.76

Downmodulation of vaccine-induced immunity and protection against the intracellular bacterium Francisella tularensis by the inhibitory receptor FcγRIIB. J Immunol Res (2015) 0.76

Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity. J Autoimmun (2015) 0.76

Testing the role of the FcγRIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response. Immun Inflamm Dis (2015) 0.75

Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI. J Leukoc Biol (2014) 0.75

Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. JCI Insight (2016) 0.75

Comment on "The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility". J Immunol (2011) 0.75

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Arthritis Res Ther (2015) 0.75

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature (2006) 9.30

The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int (2009) 7.45

The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int (2009) 7.19

Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol (2006) 6.36

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet (2007) 5.93

Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31

Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest (2004) 4.65

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol (2009) 4.63

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet (2002) 4.22

Structures of complement component C3 provide insights into the function and evolution of immunity. Nature (2005) 4.01

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet (2010) 3.74

Pathologic classification of diabetic nephropathy. J Am Soc Nephrol (2010) 3.61

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet (2002) 3.60

Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57

Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis (2013) 3.39

A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron (2004) 3.28

Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19

C3 glomerulopathy: a new classification. Nat Rev Nephrol (2010) 3.17

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med (2009) 3.12

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest (2008) 3.11

New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature (2002) 3.01

C3 glomerulopathy: consensus report. Kidney Int (2013) 2.85

Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases. Nat Immunol (2005) 2.82

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A (2002) 2.72

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A (2005) 2.70

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet (2002) 2.69

The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol (2004) 2.67

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat Med (2006) 2.65

Complement activation determines the therapeutic activity of rituximab in vivo. J Immunol (2003) 2.62

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med (2007) 2.55

Immunostaining findings in IgA nephropathy: correlation with histology and clinical outcome in the Oxford classification patient cohort. Nephrol Dial Transplant (2011) 2.51

Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell (2013) 2.49

Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol (2002) 2.43

Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum (2005) 2.32

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood (2010) 2.31

Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology (2005) 2.30

Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol (2004) 2.27

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. Am J Pathol (2005) 2.26

Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. Hepatology (2010) 2.25

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology (2006) 2.25

Critical role of galectin-3 in phagocytosis by macrophages. J Clin Invest (2003) 2.18

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity (2008) 2.16

The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults. Kidney Int (2010) 2.14

Allergy is a protective factor against age-related macular degeneration. Invest Ophthalmol Vis Sci (2014) 2.09

Pros and cons for C4d as a biomarker. Kidney Int (2012) 2.03

Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis. Nephrol Dial Transplant (2011) 2.03

MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic (2009) 1.98

Defining cell-type specificity at the transcriptional level in human disease. Genome Res (2013) 1.96

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. J Clin Invest (2008) 1.94

Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis Rheum (2005) 1.93

Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells (2006) 1.90

The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol (2010) 1.88

C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol (2002) 1.88

Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood (2005) 1.86

Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature (2010) 1.81

Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. Am J Hum Genet (2003) 1.80

Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med (2003) 1.75

Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med (2002) 1.73

Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol (2006) 1.72

Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol (2003) 1.71

IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med (2008) 1.71

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol (2004) 1.68

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol (2008) 1.68

Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J Biol Chem (2003) 1.68

Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol (2003) 1.67

Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees. Clin J Am Soc Nephrol (2011) 1.66

Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo. J Immunol (2002) 1.66

Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol (2003) 1.66

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci (2004) 1.66

The complement system in systemic autoimmune disease. J Autoimmun (2009) 1.64

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol (2004) 1.64

Interferon-beta reduces proteinuria in experimental glomerulonephritis. J Am Soc Nephrol (2007) 1.63

Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells. J Immunol (2003) 1.62

Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation (2009) 1.61

Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes. Cell (2012) 1.60

Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J Immunol (2006) 1.59

C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol (2004) 1.57

CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med (2007) 1.57

Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. J Immunol (2005) 1.55

CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice. J Am Soc Nephrol (2003) 1.54

IL-10-producing macrophages preferentially clear early apoptotic cells. Blood (2006) 1.53

Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation (2012) 1.53

Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med (2007) 1.53

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur J Immunol (2002) 1.52

TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation. Ann Rheum Dis (2012) 1.52

Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. J Clin Invest (2006) 1.51

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice. J Autoimmun (2009) 1.51