Published in Am J Ophthalmol on March 01, 2004
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med (2006) 2.99
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). J Med Genet (2005) 2.92
Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet (2006) 2.89
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med (2006) 2.18
Obesity and eye diseases. Surv Ophthalmol (2007) 2.13
CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med (2005) 2.01
Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One (2009) 1.84
Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins. Prog Retin Eye Res (2009) 1.80
Recent perspectives in ocular drug delivery. Pharm Res (2008) 1.72
Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest (2007) 1.72
Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68
Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PLoS One (2009) 1.68
Examining the relative influence of familial, genetic, and environmental covariate information in flexible risk models. Proc Natl Acad Sci U S A (2009) 1.68
Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration. Retina (2009) 1.67
Immunopathological aspects of age-related macular degeneration. Semin Immunopathol (2008) 1.63
Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A (2006) 1.63
Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study. Ophthalmology (2010) 1.52
Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. Proc Natl Acad Sci U S A (2006) 1.52
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest (2009) 1.51
Age-related macular degeneration and the immune response: implications for therapy. Am J Ophthalmol (2007) 1.49
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest (2006) 1.43
CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med (2013) 1.42
Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metab (2013) 1.42
Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration. J Lipid Res (2009) 1.41
NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep (2016) 1.40
Neighborhood Deprivation and Risk of Age-Related Eye Diseases: A Follow-up Study in Sweden. Ophthalmic Epidemiol (2015) 1.40
Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B. Proc Natl Acad Sci U S A (2009) 1.36
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PLoS One (2009) 1.34
Quantitative subanalysis of optical coherence tomography after treatment with ranibizumab for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.33
Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.31
Associated factors for age related maculopathy in the adult population in China: the Beijing eye study. Br J Ophthalmol (2006) 1.29
Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary study. Am J Ophthalmol (2007) 1.26
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol (2007) 1.23
Efficacy and safety of intravitreal therapy in macular edema due to branch and central retinal vein occlusion: a systematic review. PLoS One (2013) 1.23
Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Mol Med (2010) 1.22
Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation). Mediators Inflamm (2014) 1.20
Age and disease-related structural changes in the retinal pigment epithelium. Clin Ophthalmol (2008) 1.19
Age-period-cohort effect on the incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology (2008) 1.19
CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration. J Neuroinflammation (2010) 1.18
Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology (2010) 1.18
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration. Cell Rep (2013) 1.18
Epistatic module detection for case-control studies: a Bayesian model with a Gibbs sampling strategy. PLoS Genet (2009) 1.17
The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci (2007) 1.17
Human HtrA1 in the archived eyes with age-related macular degeneration. Trans Am Ophthalmol Soc (2007) 1.15
Vitamin D status and early age-related macular degeneration in postmenopausal women. Arch Ophthalmol (2011) 1.13
Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration. Biomed Res Int (2014) 1.13
Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. Mediators Inflamm (2010) 1.11
LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis. Mol Vis (2010) 1.11
Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages. PLoS One (2010) 1.10
Genetic studies of age-related macular degeneration: lessons, challenges, and opportunities for disease management. Ophthalmology (2012) 1.07
The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. Ophthalmology (2008) 1.07
Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria. Invest Ophthalmol Vis Sci (2009) 1.07
Polymorphism p.402Y>H in the complement factor H protein is a risk factor for age related macular degeneration in an Italian population. Br J Ophthalmol (2006) 1.06
Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol (2009) 1.05
Autofluorescence characteristics of normal foveas and reconstruction of foveal autofluorescence from limited data subsets. Invest Ophthalmol Vis Sci (2005) 1.05
Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. Hum Genet (2010) 1.04
The relation between C reactive protein and age related macular degeneration in the Cardiovascular Health Study. Br J Ophthalmol (2005) 1.03
Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the Women's Health Initiative. Arch Ophthalmol (2009) 1.02
Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. Arch Ophthalmol (2010) 1.02
Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES). BMC Genet (2009) 1.01
CKD increases the risk of age-related macular degeneration. J Am Soc Nephrol (2008) 1.01
Seeing through VEGF: innate and adaptive immunity in pathological angiogenesis in the eye. Trends Mol Med (2014) 1.00
Age-related macular degeneration-clinical review and genetics update. Clin Genet (2013) 1.00
Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach. Eur J Hum Genet (2009) 1.00
Adverse events with intravitreal injection of vascular endothelial growth factor inhibitors: nested case-control study. BMJ (2012) 1.00
Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci (2011) 0.99
Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography. J Biomed Opt (2016) 0.98
Progressive dysfunction of the retinal pigment epithelium and retina due to increased VEGF-A levels. FASEB J (2014) 0.98
CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration. J Ocul Biol Dis Infor (2010) 0.98
Smoking and age-related macular degeneration: review and update. J Ophthalmol (2013) 0.97
Comparative study of 1+PRN ranibizumab versus bevacizumab in the clinical setting. Clin Ophthalmol (2012) 0.97
Nicotine increases the VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD. Invest Ophthalmol Vis Sci (2011) 0.97
Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo. PLoS One (2011) 0.96
The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study. Ophthalmology (2007) 0.96
Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. Hum Genomics (2011) 0.95
Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study. PLoS One (2008) 0.95
Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment. EBioMedicine (2016) 0.95
Risk factors for age-related maculopathy. J Ophthalmol (2009) 0.95
IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells. Inflammation (2012) 0.94
Prevention of age-related macular degeneration. Int Ophthalmol (2010) 0.94
Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol (2006) 0.93
Stem cells as a therapeutic tool for the blind: biology and future prospects. Proc Biol Sci (2011) 0.93
C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Ophthalmology (2010) 0.92
Reconsidering the connection between vitamin D levels and age-related macular degeneration. Eye (Lond) (2011) 0.92
Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. Mol Vis (2010) 0.91
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. Ann Hum Genet (2013) 0.91
Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study. Graefes Arch Clin Exp Ophthalmol (2013) 0.91
Potential Sources and Roles of Adaptive Immunity in Age-Related Macular Degeneration: Shall We Rename AMD into Autoimmune Macular Disease? Autoimmune Dis (2014) 0.91
Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site. Mol Vis (2012) 0.90
[The role of Stratus OCT in anti-VEGF therapy. Qualitative and quantitative assessment of neovascular AMD]. Ophthalmologe (2008) 0.90
Copy number variation in the complement factor H-related genes and age-related macular degeneration. Mol Vis (2011) 0.90
Antiangiogenic therapy for ischemic retinopathies. Cold Spring Harb Perspect Med (2012) 0.89
Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med (2015) 0.89
Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. J Lipid Res (2011) 0.89
Selective retina therapy (SRT) in patients with geographic atrophy due to age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol (2009) 0.88
Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress. Apoptosis (2012) 0.88
Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2. Arterioscler Thromb Vasc Biol (2015) 0.88
A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology (2010) 4.65
Clinical classification of age-related macular degeneration. Ophthalmology (2013) 2.92
A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3. Arch Ophthalmol (2012) 2.42
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction. Proc Natl Acad Sci U S A (2007) 1.62
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest (2009) 1.51
Autofluorescence imaging in age-related macular degeneration complicated by choroidal neovascularization: a prospective study. Ophthalmology (2007) 1.51
The reading of components of diabetic retinopathy: an evolutionary approach for filtering normal digital fundus imaging in screening and population based studies. PLoS One (2013) 1.49
Macular telangiectasia type 2. Prog Retin Eye Res (2012) 1.44
The prevalence of type 2 idiopathic macular telangiectasia in two African populations. Ophthalmic Epidemiol (2012) 1.41
The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project. Invest Ophthalmol Vis Sci (2008) 1.25
Baseline characteristics of participants in the natural history study of macular telangiectasia (MacTel) MacTel Project Report No. 2. Ophthalmic Epidemiol (2010) 1.14
"En face" OCT imaging of the IS/OS junction line in type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci (2012) 1.13
Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. Int J Epidemiol (2012) 1.12
Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. Ophthalmology (2003) 1.12
Crowdsourcing as a novel technique for retinal fundus photography classification: analysis of images in the EPIC Norfolk cohort on behalf of the UK Biobank Eye and Vision Consortium. PLoS One (2013) 1.09
The prevalence of age-related maculopathy in iceland: Reykjavik eye study. Arch Ophthalmol (2003) 1.06
The Nakuru eye disease cohort study: methodology & rationale. BMC Ophthalmol (2014) 0.99
Correlation of functional impairment and morphological alterations in patients with group 2A idiopathic juxtafoveal retinal telangiectasia. Arch Ophthalmol (2008) 0.96
Structural and functional changes over time in MacTel patients. Retina (2009) 0.94
Prevalence and risk factors for diabetes and diabetic retinopathy: results from the Nigeria national blindness and visual impairment survey. BMC Public Health (2014) 0.93
Inter- and intra-observer variability in grading lesions of age-related maculopathy and macular degeneration. Graefes Arch Clin Exp Ophthalmol (2002) 0.93
The IS/OS junction layer in the natural history of type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci (2012) 0.92
The Tromsø Eye Study: study design, methodology and results on visual acuity and refractive errors. Acta Ophthalmol (2012) 0.92
Prevalence of age-related macular degeneration in elderly Caucasians: the Tromsø Eye Study. Ophthalmology (2012) 0.92
A smartphone based ophthalmoscope. Conf Proc IEEE Eng Med Biol Soc (2014) 0.90
Autofluorescence imaging of choroidal neovascularization due to age-related macular degeneration. Arch Ophthalmol (2005) 0.89
A new phenotype of macular dystrophy associated with a mitochondrial A3243G mutation. Clin Experiment Ophthalmol (2008) 0.89
Macular telangiectasia: a simplified classification. Arch Ophthalmol (2006) 0.89
Tromsø eye study: prevalence and risk factors of diabetic retinopathy. Acta Ophthalmol (2012) 0.88
Central Retinal Enrichment Supplementation Trials (CREST): design and methodology of the CREST randomized controlled trials. Ophthalmic Epidemiol (2014) 0.88
What is lost by digitizing stereoscopic fundus color slides for macular grading in age-related maculopathy and degeneration? Ophthalmology (2004) 0.88
5-year incidence of age-related maculopathy in the Reykjavik Eye Study. Ophthalmology (2005) 0.88
Prevalence of age-related maculopathy and age-related macular degeneration among the inuit in Greenland. The Greenland Inuit Eye Study. Ophthalmology (2008) 0.85
Prevalence and correlates of diabetic retinopathy in a population-based survey of older people in Nakuru, Kenya. Ophthalmic Epidemiol (2014) 0.85
Injection frequency and response to bevacizumab monotherapy for diabetic macular oedema (BOLT Report 5). Br J Ophthalmol (2013) 0.85
Retinal crystals in type 2 idiopathic macular telangiectasia. Ophthalmology (2011) 0.85
Retinal arterioles narrow with increasing duration of anti-retroviral therapy in HIV infection: a novel estimator of vascular risk in HIV? PLoS One (2012) 0.84
Localizing Microaneurysms in Fundus Images Through Singular Spectrum Analysis. IEEE Trans Biomed Eng (2016) 0.84
Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study. Acta Ophthalmol (2014) 0.83
The symmetry of phenotype between eyes of patients with early and late bilateral age-related macular degeneration (AMD). Graefes Arch Clin Exp Ophthalmol (2010) 0.83
Analysis of candidate genes for macular telangiectasia type 2. Mol Vis (2010) 0.82
Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3. Ophthalmic Epidemiol (2013) 0.82
Structural and functional measures of efficacy in response to bevacizumab monotherapy in diabetic macular oedema: exploratory analyses of the BOLT study (report 4). PLoS One (2013) 0.81
Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). Diabetologia (2014) 0.81
Agreement between time-domain and spectral-domain optical coherence tomography in the assessment of macular thickness in patients with idiopathic macular telangiectasia type 2. Ophthalmologica (2013) 0.81
Intravitreal Aflibercept for Treatment-Resistant Neovascular Age-Related Macular Degeneration: 12-Month Safety and Efficacy Outcomes. Ophthalmic Res (2015) 0.80
The International Classification system and the progression of age-related macular degeneration. Curr Eye Res (2009) 0.80
Tear fluid proteomics multimarkers for diabetic retinopathy screening. BMC Ophthalmol (2013) 0.80
Identification of a potential susceptibility locus for macular telangiectasia type 2. PLoS One (2012) 0.80
Nigeria normative data for defining glaucoma in prevalence surveys. Ophthalmic Epidemiol (2015) 0.80
Verteporfin photodynamic therapy cohort study: report 1: effectiveness and factors influencing outcomes. Ophthalmology (2009) 0.80
Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. Mech Ageing Dev (2013) 0.79
Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. PLoS Med (2013) 0.79
The 16-year incidence, progression and regression of diabetic retinopathy in a young population-based Danish cohort with type 1 diabetes mellitus: The Danish cohort of pediatric diabetes 1987 (DCPD1987). Acta Diabetol (2013) 0.78
Lactation, female hormones and age-related macular degeneration: the Tromsø Study. Br J Ophthalmol (2013) 0.78
The prevalence of age-related macular degeneration in Italy (PAMDI) study: report 1. Ophthalmic Epidemiol (2011) 0.78
Correlation between Retinal Vessel Calibre and Neurodegeneration in Patients with Type 2 Diabetes Mellitus in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR). Ophthalmic Res (2016) 0.78
Associations between autofluorescence abnormalities and visual acuity in idiopathic macular telangiectasia type 2: MacTel project report number 5. Retina (2014) 0.78
Effects of fenofibric acid on diabetic macular edema: the MacuFen study. Ophthalmic Epidemiol (2014) 0.77
PREVALENCE AND ASSOCIATIONS OF MYELINATED RETINAL NERVE FIBERS: Results From the Population-Based Gutenberg Health Study. Retina (2016) 0.77
Combined grading for choroidal neovascularisation: colour, fluorescein angiography and autofluorescence images. Graefes Arch Clin Exp Ophthalmol (2007) 0.77
Is indocyanine green angiography useful for the diagnosis of macular telangiectasia type 2? Br J Ophthalmol (2013) 0.76
Barriers to sight impairment certification in the UK: the example of a population with diabetes in East London. BMC Ophthalmol (2014) 0.75
Multimodal imaging in type 2 idiopathic macular telangiectasia. Retina (2015) 0.75
The small eye phenotype in the EPIC-Norfolk eye study: prevalence and visual impairment in microphthalmos and nanophthalmos. BMJ Open (2013) 0.75
Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. Mech Ageing Dev (2013) 0.75
Correction: Prevalence and Cardiovascular Associations of Diabetic Retinopathy and Maculopathy: Results from the Gutenberg Health Study. PLoS One (2015) 0.75
Potential Effects of Hormone Therapy in Type 2 Idiopathic Macular Telangiectasia. Ophthalmic Res (2017) 0.75
QUANTITATIVE ANALYSIS OF HYPERAUTOFLUORESCENT RINGS TO CHARACTERIZE THE NATURAL HISTORY AND PROGRESSION IN RPGR-ASSOCIATED RETINOPATHY. Retina (2017) 0.75
Measurement of retinal vessels as a biomarker of cerebrovascular ageing in older HIV positive men compared to controls. J Acquir Immune Defic Syndr (2017) 0.75
Sex differences in risk factors for retinopathy in non-diabetic men and women: the Tromsø Eye Study. Acta Ophthalmol (2013) 0.75
IDENTIFICATION OF INCREASED BLUE LIGHT REFLECTIVITY IN MACULAR TELANGIECTASIA TYPE 2 USING SCANNING LASER OPHTHALMOSCOPY VERSUS RED-FREE FUNDUS PHOTOGRAPHY. Retin Cases Brief Rep (2017) 0.75
Risk Factors and Age-Related Macular Degeneration in a Mediterranean-Basin Population: The PAMDI (Prevalence of Age-Related Macular Degeneration in Italy) Study - Report 2. Ophthalmic Res (2015) 0.75
Making star teams out of star players. Harv Bus Rev (2013) 0.75