Published in Peptides on November 01, 2003
Reawakening retrocyclins: ancestral human defensins active against HIV-1. PLoS Biol (2009) 1.80
Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol (2004) 1.58
Antimicrobial peptides: natural effectors of the innate immune system. Semin Immunopathol (2007) 1.43
Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol (2011) 1.34
A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins. BMC Genomics (2004) 1.34
The role of antimicrobial peptides at the ocular surface. Ophthalmic Res (2008) 1.32
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem (2006) 1.25
The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. PLoS One (2010) 1.19
Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother (2007) 1.13
The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Immunology (2007) 1.06
θ-Defensins: cyclic peptides with endless potential. J Biol Chem (2012) 1.05
Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun (2008) 1.03
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. PLoS One (2010) 1.03
Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf (2004) 1.00
Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections. Am J Reprod Immunol (2010) 1.00
Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections. Antimicrob Agents Chemother (2011) 0.99
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol (2009) 0.96
Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. J Leukoc Biol (2010) 0.94
Evolution of caprine and ovine beta-defensin genes. Immunogenetics (2005) 0.94
Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics (2009) 0.93
Bioinformatic and expression analysis of novel porcine beta-defensins. Mamm Genome (2006) 0.92
Cationic host defence peptides: potential as antiviral therapeutics. BioDrugs (2013) 0.92
Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells. Histochem Cell Biol (2010) 0.90
Antimicrobial peptides and proteins of the horse--insights into a well-armed organism. Vet Res (2011) 0.86
Recombinant production of rhesus θ-defensin-1 (RTD-1) using a bacterial expression system. Mol Biosyst (2012) 0.85
Retrocyclins neutralize bacterial toxins by potentiating their unfolding. Biochem J (2015) 0.85
Molecular evolution of the primate α-/θ-defensin multigene family. PLoS One (2014) 0.82
Characterization of the retrocyclin analogue RC-101 as a preventative of Staphylococcus aureus nasal colonization. Antimicrob Agents Chemother (2011) 0.82
Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus. J Immunol (2012) 0.82
Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture. J Acquir Immune Defic Syndr (2012) 0.81
The anti-HIV microbicide candidate RC-101 inhibits pathogenic vaginal bacteria without harming endogenous flora or mucosa. Am J Reprod Immunol (2012) 0.81
The first report of a Pelecaniformes defensin cluster: characterization of β-defensin genes in the crested ibis based on BAC libraries. Sci Rep (2014) 0.80
Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1). Bioorg Med Chem Lett (2012) 0.79
Structure and Biological Functions of β-Hairpin Antimicrobial Peptides. Acta Naturae (2015) 0.79
Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239. J Virol (2012) 0.78
Peptide therapeutics for treating ocular surface infections. J Ocul Pharmacol Ther (2014) 0.78
Molecular Evolutionary Analysis of β-Defensin Peptides in Vertebrates. Evol Bioinform Online (2015) 0.77
Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways. J Leukoc Biol (2015) 0.76
Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges. Sci Rep (2017) 0.75
Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins. Sci Rep (2016) 0.75
The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa. Antibiotics (Basel) (2014) 0.75
Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. J Antimicrob Chemother (2015) 0.75
In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2014) 0.75
Targeting and inactivation of bacterial toxins by human defensins. Biol Chem (2017) 0.75
The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection. J Leukoc Biol (2017) 0.75
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science (2012) 2.44
Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I. J Lipid Res (2008) 2.27
Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins. Nat Immunol (2005) 2.24
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature (2005) 2.23
Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci U S A (2002) 2.14
Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother (2005) 2.11
Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR. Proc Natl Acad Sci U S A (2006) 1.87
Reawakening retrocyclins: ancestral human defensins active against HIV-1. PLoS Biol (2009) 1.80
Retrocyclin, an antiretroviral theta-defensin, is a lectin. J Immunol (2003) 1.69
Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol (2006) 1.64
Interaction of antimicrobial peptide protegrin with biomembranes. Proc Natl Acad Sci U S A (2003) 1.61
Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol (2004) 1.58
Solid-state NMR investigation of the depth of insertion of protegrin-1 in lipid bilayers using paramagnetic Mn2+. Biophys J (2003) 1.55
Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem (2006) 1.54
Solid-state NMR investigations of peptide-lipid interaction and orientation of a beta-sheet antimicrobial peptide, protegrin. Biochemistry (2002) 1.54
Activity of alpha- and theta-defensins against primary isolates of HIV-1. J Immunol (2004) 1.50
Induction of group A Streptococcus virulence by a human antimicrobial peptide. Proc Natl Acad Sci U S A (2008) 1.45
The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses (2003) 1.40
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids. J Lipid Res (2009) 1.37
Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides. J Mol Biol (2008) 1.37
Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. J Infect Dis (2005) 1.29
Through the looking glass, mechanistic insights from enantiomeric human defensins. J Biol Chem (2009) 1.25
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem (2006) 1.25
RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. AIDS Res Hum Retroviruses (2004) 1.23
Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D. J Immunol (2009) 1.22
The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. PLoS One (2010) 1.19
Effects of guanidinium-phosphate hydrogen bonding on the membrane-bound structure and activity of an arginine-rich membrane peptide from solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2008) 1.19
Solid-state NMR investigation of the selective disruption of lipid membranes by protegrin-1. Biochemistry (2004) 1.18
Potassium release, a useful tool for studying antimicrobial peptides. J Microbiol Methods (2002) 1.18
HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41. J Immunol (2006) 1.17
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14
Immobilization and aggregation of the antimicrobial peptide protegrin-1 in lipid bilayers investigated by solid-state NMR. Biochemistry (2003) 1.14
alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s). J Infect Dis (2007) 1.14
SMAP-29 has two LPS-binding sites and a central hinge. Eur J Biochem (2002) 1.13
Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners. J Bacteriol (2010) 1.13
Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem (2010) 1.12
Avian beta-defensin nomenclature: a community proposed update. Immunol Lett (2007) 1.12
Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin. Biochemistry (2007) 1.11
Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns. Antimicrob Agents Chemother (2002) 1.11
NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2. Antimicrob Agents Chemother (2003) 1.07
The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Immunology (2007) 1.06
θ-Defensins: cyclic peptides with endless potential. J Biol Chem (2012) 1.05
Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli. Peptides (2009) 1.04
Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers. Biochemistry (2002) 1.04
Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide. J Biol Chem (2012) 1.03
Interaction of antimicrobial peptides with lipopolysaccharides. Biochemistry (2003) 1.02
Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro. FEBS Lett (2005) 1.01
Evaluation of a theta-defensin in a Murine model of herpes simplex virus type 1 keratitis. Invest Ophthalmol Vis Sci (2007) 1.00
Solid-state NMR investigation of the selective perturbation of lipid bilayers by the cyclic antimicrobial peptide RTD-1. Biochemistry (2004) 1.00
Insertion selectivity of antimicrobial peptide protegrin-1 into lipid monolayers: effect of head group electrostatics and tail group packing. Biochim Biophys Acta (2006) 0.99
Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes. Cell Microbiol (2011) 0.95
Correlation between simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides: predicting experimental toxicity. Peptides (2008) 0.94
Minidefensins: antimicrobial peptides with activity against HIV-1. Curr Pharm Des (2003) 0.93
Membrane-disruptive abilities of beta-hairpin antimicrobial peptides correlate with conformation and activity: a 31P and 1H NMR study. Biochim Biophys Acta (2005) 0.92
Orientation of a beta-hairpin antimicrobial peptide in lipid bilayers from two-dimensional dipolar chemical-shift correlation NMR. Biophys J (2006) 0.91
Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41. FEBS J (2007) 0.91
Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes. J Biol Chem (2003) 0.90
Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin-1. J Pept Sci (2005) 0.88
Direct comparison of membrane interactions of model peptides composed of only Leu and Lys residues. Biopolymers (2003) 0.88
Mechanism of supported membrane disruption by antimicrobial peptide protegrin-1. J Phys Chem B (2006) 0.87
Binding of protegrin-1 to Pseudomonas aeruginosa and Burkholderia cepacia. Respir Res (2002) 0.87
Susceptibility of Treponema pallidum to host-derived antimicrobial peptides. Peptides (2003) 0.86
De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom (2010) 0.86
Paradise lost and paradigm found. Nat Immunol (2004) 0.86
Examination of Chlamydia trachomatis infection in environments mimicking normal and abnormal vaginal pH. Sex Transm Dis (2002) 0.86
Retrocyclins: using past as prologue. Curr Protein Pept Sci (2004) 0.85
The innate immune system: a repository for future drugs? Expert Rev Anti Infect Ther (2007) 0.84
Antimicrobial host defense peptides in an arteriviral infection: differential peptide expression and virus inactivation. Viral Immunol (2009) 0.83
Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus. J Immunol (2012) 0.82
Immunology: Peptide gets in shape for self-defence. Nature (2011) 0.81
Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids. PLoS One (2010) 0.78
Immunolocalization of clavanins in Styela clava hemocytes. Dev Comp Immunol (2002) 0.77
Characterization of a lipophilin in rabbit tears. Adv Exp Med Biol (2002) 0.77
Paradoxical effects of two theta-defensins on HIV type 1 infection. AIDS Res Hum Retroviruses (2007) 0.76
Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif. Adv Exp Med Biol (2009) 0.75