In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis).

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4311673)

Published in Trans Am Ophthalmol Soc on July 01, 2014

Authors

Harminder S Dua1, Ahmad Muneer Otri1, Andrew Hopkinson1, Imran Mohammed1

Author Affiliations

1: Academic Department of Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham, England.

Articles cited by this

(truncated to the top 100)

Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol (2000) 29.28

Antimicrobial peptides of multicellular organisms. Nature (2002) 23.50

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 17.42

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (1995) 11.16

Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest (1985) 8.63

A peptide antibiotic from human skin. Nature (1997) 7.64

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature (1999) 7.31

Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev (2003) 6.57

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (1999) 6.49

Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem (2000) 6.19

Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13

Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell (1997) 5.99

Peptide antibiotics. Antimicrob Agents Chemother (1999) 5.76

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell (1990) 5.59

Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55

An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci (1995) 4.19

Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem (1992) 4.04

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 3.90

Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85

The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem (1997) 3.82

hBD-1: a novel beta-defensin from human plasma. FEBS Lett (1995) 3.79

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74

Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis (2001) 3.54

Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol (2003) 3.41

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med (2005) 3.37

Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob Agents Chemother (1997) 3.12

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet (2002) 3.01

Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr Opin Pharmacol (2006) 2.95

Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J Biol Chem (1998) 2.91

Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect Immun (1995) 2.87

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem (1996) 2.60

Human beta-defensins. Cell Mol Life Sci (2006) 2.57

Defensins. Curr Opin Immunol (1994) 2.55

Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol (2000) 2.55

Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest (1991) 2.54

Antimicrobial peptides: the ancient arm of the human immune system. Virulence (2010) 2.51

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol (2006) 2.48

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med (2006) 2.46

Epithelial antimicrobial peptides in host defense against infection. Respir Res (2000) 2.40

DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol (2006) 2.36

Antimicrobial peptides from human platelets. Infect Immun (2002) 2.32

Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol (2001) 2.29

Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24

Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol (1998) 2.19

Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis (1995) 2.16

Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci U S A (1997) 2.11

Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol (2004) 2.05

Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J Immunol (2005) 2.03

Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene (1998) 1.99

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99

A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res (2005) 1.97

A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis. Immunology (2002) 1.93

Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes. Infect Immun (2003) 1.90

beta-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol (2001) 1.89

CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem (2000) 1.89

Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut (2001) 1.88

Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. Infect Immun (1999) 1.87

Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol (2003) 1.82

[beta]-defensins in lung host defense. Annu Rev Physiol (2002) 1.80

Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett (2005) 1.78

Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol (2005) 1.76

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J Clin Invest (1990) 1.74

Innate defence of the eye by antimicrobial defensin peptides. Lancet (1998) 1.72

Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect Immun (2000) 1.69

Synergistic actions of antibacterial neutrophil defensins and cathelicidins. Inflamm Res (2000) 1.67

The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates. J Biol Chem (1996) 1.67

Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proc Natl Acad Sci U S A (2002) 1.64

Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest (1988) 1.63

Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes Infect (2005) 1.62

Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrob Agents Chemother (2001) 1.56

Tissue distribution of antileukoprotease and lysozyme in humans. J Histochem Cytochem (1989) 1.51

Ocular surface epithelia express mRNA for human beta defensin-2. Exp Eye Res (1999) 1.50

Human alpha-defensins block papillomavirus infection. Proc Natl Acad Sci U S A (2006) 1.48

Antimicrobial defensin peptides of the human ocular surface. Br J Ophthalmol (1999) 1.44

Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides (2003) 1.42

Biological properties of structurally related alpha-helical cationic antimicrobial peptides. Infect Immun (1999) 1.40

Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci (2003) 1.39

Laboratory findings in tear fluid analysis. Clin Chim Acta (2006) 1.36

Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res (2002) 1.35

The role of antimicrobial peptides at the ocular surface. Ophthalmic Res (2008) 1.32

Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK. J Biol Chem (2009) 1.32

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem (2004) 1.31

TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30

Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro. Regul Pept (2001) 1.30

Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa. Infect Immun (2005) 1.29

Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines. Blood (1993) 1.28

Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy. Hum Gene Ther (1999) 1.27

Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol (2005) 1.26

Defensins in innate immunity. Cell Tissue Res (2010) 1.25

Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. J Clin Invest (1998) 1.25

Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues. J Histochem Cytochem (2002) 1.20

Human neutrophil defensin and serpins form complexes and inactivate each other. Am J Respir Cell Mol Biol (1995) 1.20

AP-1 activated by toll-like receptors regulates expression of IL-23 p19. J Biol Chem (2009) 1.17

NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation. J Leukoc Biol (2002) 1.17

Neutrophil-derived azurocidin alarms the immune system. J Leukoc Biol (2008) 1.13

Multifunctional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci (2006) 1.13

Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am J Respir Cell Mol Biol (2003) 1.11

Characterization of human tear proteome using multiple proteomic analysis techniques. J Proteome Res (2005) 1.11

The RNase a superfamily: generation of diversity and innate host defense. Mol Divers (2006) 1.10

Control of mucin production by ocular surface epithelial cells. Exp Eye Res (2004) 1.10