Published in Peptides on November 01, 2003
Alpha-defensins in enteric innate immunity: functional Paneth cell alpha-defensins in mouse colonic lumen. J Biol Chem (2009) 1.28
The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability. J Biol Chem (2008) 1.16
Paneth cell α-defensins in enteric innate immunity. Cell Mol Life Sci (2011) 1.16
Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure. Infect Immun (2009) 1.04
Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry (2008) 1.04
Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol (2005) 1.01
Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol (2004) 0.99
In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases. J Biol Chem (2008) 0.95
Anionic amino acids near the pro-alpha-defensin N terminus mediate inhibition of bactericidal activity in mouse pro-cryptdin-4. J Biol Chem (2008) 0.95
The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids (2012) 0.89
Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. J Biol Chem (2012) 0.89
Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J Biol Chem (2010) 0.85
Alternative luminal activation mechanisms for paneth cell α-defensins. J Biol Chem (2012) 0.82
Hydrophobic determinants of α-defensin bactericidal activity. Infect Immun (2014) 0.81
Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun (2013) 0.79
Inhibition of bactericidal activity is maintained in a mouse alpha-defensin precursor with proregion truncations. Peptides (2009) 0.76
Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions. Antibiotics (Basel) (2014) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Mammalian defensins in the antimicrobial immune response. Nat Immunol (2005) 4.84
Antimicrobial peptides from human platelets. Infect Immun (2002) 2.32
Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem (2001) 1.63
Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angew Chem Int Ed Engl (2008) 1.48
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem (2001) 1.41
Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem (2004) 1.36
alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors. AIDS (2003) 1.34
The human islet amyloid polypeptide forms transient membrane-active prefibrillar assemblies. Biochemistry (2003) 1.30
Carbohydrate biosensors. Chem Rev (2004) 1.25
Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. J Immunol (2006) 1.24
Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol (2007) 1.23
Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem (2002) 1.20
Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem (2003) 1.20
Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem (2003) 1.19
Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils. J Biol Chem (2002) 1.18
Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother (2007) 1.13
Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem (2006) 1.09
Intramembrane electrostatic interactions destabilize lipid vesicles. Biophys J (2002) 1.09
Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem (2006) 1.08
Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol (2004) 1.07
The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol (2005) 1.06
A novel role for lipid droplets in the organismal antibacterial response. Elife (2012) 1.06
θ-Defensins: cyclic peptides with endless potential. J Biol Chem (2012) 1.05
Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry (2008) 1.04
Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun (2005) 1.03
Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation. J Control Release (2011) 1.03
Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun (2008) 1.03
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. PLoS One (2010) 1.03
Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol (2004) 0.99
Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun (2004) 0.98
Cytochrome c causes pore formation in cardiolipin-containing membranes. Proc Natl Acad Sci U S A (2013) 0.97
Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem (2004) 0.96
Specific binding of different vesicle populations by the hybridization of membrane-anchored DNA. J Phys Chem A (2007) 0.96
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol (2009) 0.96
Visualization of membrane processes in living cells by surface-attached chromatic polymer patches. Angew Chem Int Ed Engl (2005) 0.96
Single vesicle observations of the cardiolipin-cytochrome C interaction: induction of membrane morphology changes. Langmuir (2011) 0.94
Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem (2001) 0.94
Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. J Leukoc Biol (2010) 0.94
Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry (2004) 0.93
Material studies of lipid vesicles in the L(alpha) and L(alpha)-gel coexistence regimes. Biophys J (2003) 0.92
Lipid binding and membrane penetration of polymyxin B derivatives studied in a biomimetic vesicle system. Biochem J (2003) 0.91
Calcium modulates the mechanical properties of anionic phospholipid membranes. J Colloid Interface Sci (2003) 0.90
Giant phospholipid/block copolymer hybrid vesicles: mixing behavior and domain formation. Langmuir (2010) 0.90
CMOS low current measurement system for biomedical applications. IEEE Trans Biomed Circuits Syst (2012) 0.90
Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One (2012) 0.89
Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells. Chembiochem (2011) 0.89
Control of adhesion and surface forces via potential-dependent adsorption of pyridine. J Phys Chem B (2005) 0.88
Biomimetic lipid/polymer colorimetric membranes: molecular and cooperative properties. J Lipid Res (2003) 0.87
Structures and mode of membrane interaction of a short alpha helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy. Eur J Biochem (2002) 0.86
Color fingerprinting of proteins by calixarenes embedded in lipid/polydiacetylene vesicles. J Am Chem Soc (2006) 0.86
Rapid colorimetric screening of drug interaction and penetration through lipid barriers. Pharm Res (2006) 0.86
The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother (2008) 0.86
Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res (2011) 0.85
Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils. Biophys J (2013) 0.85
Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability. J Med Chem (2007) 0.85
Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface. Langmuir (2008) 0.85
Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion. J Phys Chem B (2010) 0.85
Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide. J Biotechnol (2003) 0.84
Membrane interactions of ionic liquids: possible determinants for biological activity and toxicity. Biochim Biophys Acta (2012) 0.84
Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry (2011) 0.84
Reversible assembly of stacked membrane nanodiscs with reduced dimensionality and variable periodicity. J Am Chem Soc (2013) 0.83
A hierarchy of lipid constructs for the sperm plasma membrane. Biochem Biophys Res Commun (2003) 0.83
High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One (2012) 0.83
Membrane interactions of host-defense peptides studied in model systems. Curr Protein Pept Sci (2005) 0.83
Alternative luminal activation mechanisms for paneth cell α-defensins. J Biol Chem (2012) 0.82
Investigations of antimicrobial peptides in planar film systems. Biochim Biophys Acta (2006) 0.82
The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorg Med Chem (2009) 0.82
Divergent heparin-induced fibrillation pathways of a prion amyloidogenic determinant. Chembiochem (2010) 0.81
Hydrophobic determinants of α-defensin bactericidal activity. Infect Immun (2014) 0.81
Specific mutations alter fibrillation kinetics, fiber morphologies, and membrane interactions of pentapeptides derived from human calcitonin. Biochemistry (2010) 0.81
Pardaxin, a fish toxin peptide interaction with a biomimetic phospholipid/polydiacetylene membrane assay. Peptides (2008) 0.81
DNA as membrane-bound ligand-receptor pairs: duplex stability is tuned by intermembrane forces. Biophys J (2009) 0.81
Bolaamphiphilic vesicles encapsulating iron oxide nanoparticles: new vehicles for magnetically targeted drug delivery. Int J Pharm (2013) 0.81
Partitioning of membrane-anchored DNA between coexisting lipid phases. J Phys Chem B (2009) 0.81
N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity. Chembiochem (2011) 0.80