Published in J Biol Chem on February 27, 2004
Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic Biol Med (2009) 1.45
Degranulation of paneth cells via toll-like receptor 9. Am J Pathol (2004) 1.36
Paneth cells: their role in innate immunity and inflammatory disease. Gut (2005) 1.32
Molecular modulation of intestinal epithelial barrier: contribution of microbiota. J Biomed Biotechnol (2010) 1.25
Structure-dependent functional properties of human defensin 5. FEBS Lett (2007) 1.07
High alpha-defensin levels in patients with systemic lupus erythematosus. Immunology (2009) 0.96
The role of intestinal epithelial barrier function in the development of NEC. Tissue Barriers (2015) 0.90
Synthetic small intestinal scaffolds for improved studies of intestinal differentiation. Biotechnol Bioeng (2014) 0.89
Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera. Infect Immun (2015) 0.85
Enteric alpha defensins in norm and pathology. Ann Clin Microbiol Antimicrob (2012) 0.83
Pathogenesis of NEC: Role of the innate and adaptive immune response. Semin Perinatol (2016) 0.75
Immunonutrition enhances the expression and secretion of mouse intestinal defensins. Gut (2006) 0.75
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54
Mammalian defensins in the antimicrobial immune response. Nat Immunol (2005) 4.84
Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol (2003) 4.00
Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A (2005) 3.52
Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05
Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity (2004) 2.79
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. J Immunol (2002) 2.70
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci (2006) 2.59
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe (2012) 2.48
Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol (2003) 2.43
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut (2013) 2.32
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med (2002) 2.32
Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell (2003) 2.22
Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol (2002) 2.22
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest (2006) 2.16
Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol (2008) 2.07
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest (2009) 2.06
Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol (2010) 2.05
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology (2005) 2.03
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem (2003) 2.01
Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol (2002) 1.95
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One (2012) 1.90
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J (2007) 1.86
Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A (2008) 1.82
The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation. J Immunol (2009) 1.78
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77
An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology (2009) 1.71
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep (2002) 1.71
Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci U S A (2004) 1.69
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade. Cell Host Microbe (2008) 1.69
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol (2009) 1.68
Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor. Am J Physiol Endocrinol Metab (2006) 1.68
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res (2009) 1.67
Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation. J Cell Biol (2006) 1.67
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am J Physiol Cell Physiol (2004) 1.65
Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett (2006) 1.65
Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A (2004) 1.63
Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem (2001) 1.63
Bacterial activation of beta-catenin signaling in human epithelia. Am J Physiol Gastrointest Liver Physiol (2004) 1.60
Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest (2010) 1.59
Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem (2002) 1.58
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57
Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm Bowel Dis (2007) 1.57
Derlin-1 facilitates the retro-translocation of cholera toxin. Mol Biol Cell (2007) 1.55
Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor. Mol Biol Cell (2004) 1.54
Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol (2006) 1.54
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology (2012) 1.52
Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol (2010) 1.50
Balloon-occluded retrograde transvenous obliteration of gastric varices. Cardiovasc Intervent Radiol (2013) 1.50
TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J Immunol (2006) 1.50
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol (2005) 1.49
Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest (2007) 1.47
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46
Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2005) 1.45
Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic Biol Med (2009) 1.45
Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol (2006) 1.45
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A (2011) 1.44
Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol. J Biol Chem (2002) 1.43
IL-6 induces NF-kappa B activation in the intestinal epithelia. J Immunol (2003) 1.42
Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol (2004) 1.41
Cutting edge: bacterial modulation of epithelial signaling via changes in neddylation of cullin-1. J Immunol (2005) 1.40
Shanthi V. Sitaraman, MD, PhD: physician, scientist, educator, and humanitarian. Gastroenterology (2011) 1.39
Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited. Annu Rev Pathol (2013) 1.38
Toll-like receptor-gut microbiota interactions: perturb at your own risk! Annu Rev Physiol (2011) 1.38
In"sight" into immune blindness: Helicobacter pylori-induced gastritis requires T cells primed in the small intestine Peyer's patches. Gastroenterology (2007) 1.38
TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol (2003) 1.38
Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circ Res (2009) 1.37
TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur J Immunol (2010) 1.37
Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun (2008) 1.37
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. J Pediatr (2010) 1.36
Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem (2004) 1.36
Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species. EMBO J (2013) 1.35
Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel) (2010) 1.34
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem (2005) 1.33
The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption. Cell Microbiol (2007) 1.33
Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell (2004) 1.32
Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics. Crit Rev Biotechnol (2013) 1.31
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.31
Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol (2008) 1.30
Latent cytomegalovirus infection exacerbates experimental colitis. Am J Pathol (2009) 1.30
The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies. Hum Mol Genet (2011) 1.30
Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Semin Immunopathol (2009) 1.29
Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep (2004) 1.28
Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. Proc Natl Acad Sci U S A (2011) 1.28