Published in Trends Pharmacol Sci on March 01, 2004
PANDA (Pediatric Anesthesia & NeuroDevelopment Assessment) Study | NCT00881764
Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology (2009) 9.51
Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg (2011) 3.08
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol (2011) 2.41
Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice. Anesthesiology (2010) 2.08
Infant pain management: a developmental neurobiological approach. Nat Clin Pract Neurol (2009) 1.76
Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity. Neurosci Lett (2007) 1.53
Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology (2009) 1.47
Anesthesia, calcium homeostasis and Alzheimer's disease. Curr Alzheimer Res (2009) 1.37
Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia (2013) 1.32
The ketogenic diet in a pill: is this possible? Epilepsia (2008) 1.28
Pediatric anesthesia and neurodevelopmental impairments: a Bayesian meta-analysis. J Neurosurg Anesthesiol (2012) 1.22
Neurotoxicity of general anesthetics: cause for concern? Anesthesiology (2009) 1.13
A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol (2009) 0.97
Neurodevelopment of children exposed to anesthesia: design of the Mayo Anesthesia Safety in Kids (MASK) study. Contemp Clin Trials (2014) 0.95
Neuropathological sequelae of developmental exposure to antiepileptic and anesthetic drugs. Front Neurol (2012) 0.90
Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis. Am J Pathol (2009) 0.89
The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants. Front Pharmacol (2011) 0.87
The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. Int J Dev Neurosci (2011) 0.83
Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clin Pharmacol (2010) 0.83
Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro. J Neural Transm (Vienna) (2006) 0.82
Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder. Neuropharmacology (2008) 0.82
Differential effects of AMPA receptor activation on survival and neurite integrity during neuronal development. Mol Cell Neurosci (2007) 0.81
Isoflurane suppresses early cortical activity. Ann Clin Transl Neurol (2013) 0.80
New concepts in treatment of pediatric traumatic brain injury. Anesthesiol Clin (2009) 0.79
Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. PLoS One (2015) 0.76
Impact of transient acute hypoxia on the developing mouse EEG. Neurobiol Dis (2014) 0.76
Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling. Brain Sci (2015) 0.76
The 2008 Judith Hoyer lecture: epilepsy in children: listening to mothers. Epilepsy Behav (2009) 0.76
Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis. Neurobiol Dis (2015) 0.76
FTIR Microspectroscopy Reveals Chemical Changes in Mice Fetus Following Phenobarbital Administration. Iran J Pharm Res (2015) 0.75
Sevoflurane inhibits the phosphorylation of ribosomal protein S6 in neonatal rat brain. Int J Clin Exp Med (2015) 0.75
EEG Monitoring and Antiepileptic Drugs in Children with Severe TBI. Neurocrit Care (2016) 0.75
Influences of medications on the developing fetus: toward deciphering the unknowns. Pediatr Res (2017) 0.75
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci (2003) 7.42
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A (2002) 4.18
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? Anesthesiology (2004) 3.22
Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Ann Neurol (2014) 3.01
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab (2010) 2.63
Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol (2005) 2.61
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome. Arthritis Rheum (2010) 2.50
Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol (2008) 2.46
Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis (2004) 2.24
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci U S A (2004) 2.11
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci (2003) 2.01
Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain. Anesth Analg (2008) 1.96
Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron (2002) 1.91
Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J Neurosci (2005) 1.90
Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Brain Res Dev Brain Res (2002) 1.89
Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol (2002) 1.85
Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice. J Neurosurg Anesthesiol (2008) 1.80
General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Apoptosis (2006) 1.76
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab (2013) 1.74
Clinical anesthesia causes permanent damage to the fetal guinea pig brain. Brain Pathol (2008) 1.71
Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci (2007) 1.69
PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg (2008) 1.62
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest (2013) 1.57
Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Can J Anaesth (2008) 1.57
Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness. J Neurosci (2006) 1.56
Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg (2009) 1.55
Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Am J Pathol (2008) 1.54
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci (2007) 1.52
Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain. Neurobiol Dis (2005) 1.52
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci (2010) 1.51
Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Exp Neurol (2005) 1.51
Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol (2004) 1.49
Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci U S A (2008) 1.41
Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol (2008) 1.37
Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci (2010) 1.37
Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiol Dis (2007) 1.37
General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology (2011) 1.36
Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A (2004) 1.36
Lithium protects against anesthesia-induced developmental neuroapoptosis. Anesthesiology (2009) 1.33
Levetiracetam: safety and efficacy in neonatal seizures. Eur J Paediatr Neurol (2010) 1.33
Expression of glutamate receptor subunits in human cancers. Histochem Cell Biol (2009) 1.31
NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc Natl Acad Sci U S A (2005) 1.30
Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain. Neurobiol Dis (2004) 1.30
Antisense reduction of tau in adult mice protects against seizures. J Neurosci (2013) 1.29
Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. J Neurosci (2006) 1.28
Low doses of memantine disrupt memory in adult rats. J Neurosci (2006) 1.27
Erythropoietin protects the developing brain against N-methyl-D-aspartate receptor antagonist neurotoxicity. Neurobiol Dis (2004) 1.23
Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B. PLoS One (2007) 1.23
Oxygen causes cell death in the developing brain. Neurobiol Dis (2004) 1.18
Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice. Hum Mol Genet (2010) 1.18
CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol (2006) 1.18
Therapeutic efficacy of bone marrow transplant, intracranial AAV-mediated gene therapy, or both in the mouse model of MPS IIIB. Mol Ther (2010) 1.16
Recurrent moderate hypoglycemia ameliorates brain damage and cognitive dysfunction induced by severe hypoglycemia. Diabetes (2010) 1.15
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes (2009) 1.15
T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol (2011) 1.15
TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol (2011) 1.15
Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res (2002) 1.14
Multiple episodes of mild traumatic brain injury result in impaired cognitive performance in mice. Acad Emerg Med (2004) 1.14
Anticancer agents are potent neurotoxins in vitro and in vivo. Ann Neurol (2004) 1.13
Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. J Neurosci (2010) 1.13
Cerebellar pathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse. Exp Neurol (2009) 1.13
Ethanol-induced apoptosis in the developing visual system during synaptogenesis. Invest Ophthalmol Vis Sci (2003) 1.12
Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. J Neurosci (2011) 1.12
Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain. Anesthesiology (2013) 1.11
Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia. Neurotox Res (2009) 1.11
The enigma of fetal alcohol neurotoxicity. Ann Med (2002) 1.08
Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in rats. Brain Res (2005) 1.08
Brief alteration of NMDA or GABAA receptor-mediated neurotransmission has long term effects on the developing cerebral cortex. Mol Cell Proteomics (2008) 1.07
Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit. Proc Natl Acad Sci U S A (2005) 1.06
The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. J Neurosci (2013) 1.05
The role of matrix metalloproteinases in infant traumatic brain injury. Neurobiol Dis (2006) 1.03
Isoflurane impairs immature astroglia development in vitro: the role of actin cytoskeleton. J Neuropathol Exp Neurol (2011) 1.03
RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo. Neuro Oncol (2011) 0.99
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia. Pain (2004) 0.99
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PLoS One (2012) 0.98
Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin) (2007) 0.98
Glutamate receptors in pediatric tumors of the central nervous system. Cancer Biol Ther (2010) 0.98
The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol Disord Drug Targets (2006) 0.98
Dopamine deficiency underlies learning deficits in neurofibromatosis-1 mice. Ann Neurol (2012) 0.97
Silencing of selected glutamate receptor subunits modulates cancer growth. Anticancer Res (2011) 0.97
Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol (2006) 0.96
An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects. Exp Neurol (2003) 0.95
Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain. Neurobiol Dis (2002) 0.95
Glutamate antagonists limit tumor growth. Biochem Pharmacol (2002) 0.95
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci (2009) 0.95
PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice. Exp Neurol (2011) 0.94
Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects. Neuropsychopharmacology (2007) 0.94