Published in Science on March 19, 2004
Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. Proc Natl Acad Sci U S A (2007) 1.16
Public health. Grand Challenges in Global Health. Science (2003) 7.91
The grand challenge of birth control. Science (2004) 1.09
Derivation of oocytes from mouse embryonic stem cells. Science (2003) 4.03
Inflammation and pregnancy. Reprod Sci (2009) 3.33
A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth. Am J Obstet Gynecol (2004) 2.60
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature (2008) 2.09
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines. Cancer Biol Ther (2003) 1.88
Family-based analysis of candidate genes for polycystic ovary syndrome. J Clin Endocrinol Metab (2010) 1.84
Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril (2006) 1.75
Patient-centered cancer treatment planning: improving the quality of oncology care. Summary of an Institute of Medicine workshop. Oncologist (2011) 1.67
The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. J Biol Chem (2003) 1.59
Health disparities in risk for cervical insufficiency. Hum Reprod (2010) 1.58
Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab (2006) 1.51
Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts. J Med Genet (2011) 1.51
A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes. J Biol Chem (2001) 1.42
NIH funding reform. Science (2005) 1.41
Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome. Mol Cell Endocrinol (2011) 1.38
Genetic contributions to disparities in preterm birth. Pediatr Res (2009) 1.37
Molecular progress in infertility: polycystic ovary syndrome. Fertil Steril (2002) 1.36
Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet (2004) 1.35
Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies. BMC Genomics (2010) 1.34
Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype. Proc Natl Acad Sci U S A (2014) 1.28
A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans. Proc Natl Acad Sci U S A (2006) 1.27
Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the Periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol (2010) 1.26
Genomics and perinatal care. N Engl J Med (2012) 1.26
Temporal and spatial changes in transcription factor binding and histone modifications at the steroidogenic acute regulatory protein (stAR) locus associated with stAR transcription. Mol Endocrinol (2004) 1.22
Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16. Mol Cell Proteomics (2005) 1.21
Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. Mol Endocrinol (2004) 1.18
Opening up to precompetitive collaboration. Sci Transl Med (2010) 1.18
A polymorphism in the matrix metalloproteinase-9 promoter is associated with increased risk of preterm premature rupture of membranes in African Americans. Mol Hum Reprod (2002) 1.17
Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc Natl Acad Sci U S A (2004) 1.17
FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS One (2011) 1.16
Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis. J Clin Endocrinol Metab (2012) 1.14
Syncytiotrophoblast is a barrier to maternal-fetal transmission of herpes simplex virus. Biol Reprod (2002) 1.14
Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Biol Reprod (2005) 1.14
A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16. Mol Cell Biol (2002) 1.12
The promoter of the oocyte-specific gene, Gdf9, is active in population of cultured mouse embryonic stem cells with an oocyte-like phenotype. Methods (2008) 1.10
MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria. J Biol Chem (2002) 1.07
Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins. Cell Motil Cytoskeleton (2007) 1.07
A single nucleotide polymorphism in the promoter of the LOXL1 gene and its relationship to pelvic organ prolapse and preterm premature rupture of membranes. Reprod Sci (2009) 1.06
Mechanisms underlying "functional" progesterone withdrawal at parturition. Ann N Y Acad Sci (2004) 1.04
Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins. Mol Hum Reprod (2005) 1.04
Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. PLoS One (2011) 1.04
Sex hormone-binding globulin and type 2 diabetes mellitus. Trends Endocrinol Metab (2011) 1.02
Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study. BMC Med Genet (2011) 1.01
Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes. Hum Mol Genet (2008) 1.01
Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches. Twin Res Hum Genet (2009) 1.00
Racial differences in genetic and environmental risk to preterm birth. PLoS One (2010) 0.99
Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone. Mol Reprod Dev (2009) 0.99
Valproate potentiates androgen biosynthesis in human ovarian theca cells. Endocrinology (2003) 0.98
MEIG1 is essential for spermiogenesis in mice. Proc Natl Acad Sci U S A (2009) 0.98
The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol (2004) 0.98
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem (2004) 0.98
Variation in resistin gene promoter not associated with polycystic ovary syndrome. Diabetes (2003) 0.97
Genetics of polycystic ovarian syndrome. Clin Obstet Gynecol (2007) 0.96
Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation? J Reprod Immunol (2002) 0.96
Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. Dev Biol (2008) 0.96
Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab (2005) 0.95
Induction of the hyaluronic acid-binding protein, tumor necrosis factor-stimulated gene-6, in cervical smooth muscle cells by tumor necrosis factor-alpha and prostaglandin E(2). Am J Pathol (2002) 0.95
Control of human luteal steroidogenesis. Mol Cell Endocrinol (2002) 0.94
Activation of the control reporter plasmids pRL-TK and pRL-SV40 by multiple GATA transcription factors can lead to aberrant normalization of transfection efficiency. BMC Biotechnol (2004) 0.93
Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. Mol Endocrinol (2004) 0.93
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. Physiol Genomics (2004) 0.93
Tumor necrosis factor-alpha suppresses the expression of steroid receptor coactivator-1 and -2: a possible mechanism contributing to changes in steroid hormone responsiveness. FASEB J (2004) 0.93
Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5. J Biol Chem (2010) 0.92
A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme. Biol Reprod (2007) 0.91
Medicaid and preterm birth and low birth weight: the last two decades. J Womens Health (Larchmt) (2010) 0.91
Fetal and maternal genes' influence on gestational age in a quantitative genetic analysis of 244,000 Swedish births. Am J Epidemiol (2013) 0.91
Regulation of transcription of the steroidogenic acute regulatory protein (StAR) gene: temporal and spatial changes in transcription factor binding and histone modification. Mol Cell Endocrinol (2004) 0.90
Spag16, an axonemal central apparatus gene, encodes a male germ cell nuclear speckle protein that regulates SPAG16 mRNA expression. PLoS One (2011) 0.89
Genetic approaches to polycystic ovarian syndrome. Curr Opin Obstet Gynecol (2007) 0.89
The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM). Mol Hum Reprod (2002) 0.88
Accelerating cancer therapy development: the importance of combination strategies and collaboration. Summary of an Institute of Medicine workshop. Clin Cancer Res (2012) 0.88
Persistence pays off for PCOS gene prospectors. J Clin Endocrinol Metab (2012) 0.87
DNA methylation is altered in maternal blood vessels of women with preeclampsia. Reprod Sci (2012) 0.87
Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. FASEB J (2003) 0.87
Reducing tobacco-related cancer incidence and mortality: summary of an institute of medicine workshop. Oncologist (2013) 0.87
Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? Am J Obstet Gynecol (2010) 0.86
Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia. Hypertension (2012) 0.86
Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction. Am J Pathol (2010) 0.86
Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. J Clin Endocrinol Metab (2003) 0.86
Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells. J Clin Endocrinol Metab (2005) 0.86
Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertil Steril (2011) 0.86
Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival. Am J Respir Cell Mol Biol (2013) 0.85
Multiple signal transduction pathways regulate ovarian steroidogenesis. Rev Endocr Metab Disord (2002) 0.85
Contact sites from human placental mitochondria: characterization and role in progesterone synthesis. Arch Biochem Biophys (2003) 0.85
Strategies to facilitate the development of new contraceptives. Nat Rev Drug Discov (2004) 0.84
Human corpus luteum physiology and the luteal-phase dysfunction associated with ovarian stimulation. Reprod Biomed Online (2009) 0.84
Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2. Biol Reprod (2008) 0.84
Cholesterol side-chain cleavage gene expression in theca cells: augmented transcriptional regulation and mRNA stability in polycystic ovary syndrome. PLoS One (2012) 0.83
Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro. Am J Pathol (2003) 0.83
Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells. J Clin Endocrinol Metab (2002) 0.83
PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. Mol Hum Reprod (2009) 0.83
A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk. Mol Genet Genomic Med (2013) 0.82
TSKS concentrates in spermatid centrioles during flagellogenesis. Dev Biol (2008) 0.82
Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab (2011) 0.82
Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism. Am J Pathol (2012) 0.82
A 12-bp deletion in the 5'-flanking region of the SERPINH1 gene affects promoter activity and protects against preterm premature rupture of membranes in African Americans. Hum Mutat (2008) 0.82
The human corpus luteum: life cycle and function in natural cycles. Fertil Steril (2008) 0.81
Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer (START) domains of StAR (STARD1) and MLN64 (STARD3). FEBS J (2008) 0.81
The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase. J Clin Endocrinol Metab (2003) 0.81