Published in J Clin Invest on April 01, 2004
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature (2008) 6.13
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest (2005) 3.96
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev (2010) 2.68
Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proc Natl Acad Sci U S A (2010) 2.61
MAPK signalling: ERK5 versus ERK1/2. EMBO Rep (2006) 2.19
Mitogen-activated protein kinases in heart development and diseases. Circulation (2007) 1.84
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A (2008) 1.80
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell (2010) 1.72
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol (2005) 1.57
Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol (2005) 1.51
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40
MEK5/ERK5 pathway: the first fifteen years. Biochim Biophys Acta (2011) 1.39
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Mol Cell Biol (2005) 1.38
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol Cell Biol (2005) 1.37
Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target. PLoS One (2009) 1.35
Thymic emigration: when and how T cells leave home. J Immunol (2008) 1.31
Genetics and heritability of coronary artery disease and myocardial infarction. Clin Res Cardiol (2006) 1.29
Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. Mol Cell Biol (2006) 1.18
A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol (2005) 1.12
RSK in tumorigenesis: connections to steroid signaling. Steroids (2010) 1.08
PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol (2006) 1.07
Vascular endothelial growth factor induces MEF2C and MEF2-dependent activity in endothelial cells. Invest Ophthalmol Vis Sci (2008) 1.06
Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ Res (2010) 1.06
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction. Circ J (2011) 1.03
Cellular signaling and potential new treatment targets in diabetic retinopathy. Exp Diabetes Res (2007) 1.02
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryot Cell (2006) 1.02
Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res (2011) 1.02
Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis. EMBO J (2008) 0.99
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis (2013) 0.97
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation (2012) 0.96
MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover. J Biol Chem (2009) 0.95
Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun (2008) 0.95
Forkhead BoxO transcription factors restrain exercise-induced angiogenesis. J Physiol (2014) 0.94
ERK5 is a critical mediator of inflammation-driven cancer. Cancer Res (2015) 0.92
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. Oncogene (2012) 0.92
Regulation of vascular integrity. J Mol Med (Berl) (2009) 0.92
Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5. J Immunol (2010) 0.91
Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet (2011) 0.91
Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow. J Biol Chem (2007) 0.90
Undermining the endothelium by ablation of MAPK-MEF2 signaling. J Clin Invest (2004) 0.90
Requirement of the MEK5-ERK5 pathway for neural differentiation in Xenopus embryonic development. EMBO Rep (2005) 0.90
Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas. Clin Cancer Res (2013) 0.89
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis. Angiogenesis (2008) 0.89
SUMO--a post-translational modification with therapeutic potential? Curr Opin Pharmacol (2010) 0.89
Novel mechanisms of endothelial mechanotransduction. Arterioscler Thromb Vasc Biol (2014) 0.89
Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: new insights from ERK5 MAP kinase. Neurobiol Learn Mem (2013) 0.88
Dynamic purine signaling and metabolism during neutrophil-endothelial interactions. Purinergic Signal (2005) 0.88
Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J Biol Chem (2013) 0.88
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives. Pharmacol Ther (2014) 0.88
Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2α activation. PLoS One (2012) 0.87
X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor. J Med Chem (2013) 0.86
Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer. BMC Cancer (2012) 0.85
The case for inhibiting p38 mitogen-activated protein kinase in heart failure. Front Pharmacol (2015) 0.84
Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J Biol Chem (2012) 0.84
Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. PLoS One (2014) 0.84
Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. Front Pharmacol (2014) 0.83
Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma. BMC Cancer (2015) 0.82
ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma. Neoplasia (2013) 0.82
Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. J Immunol (2014) 0.82
MEF2 transcription factors: developmental regulators and emerging cancer genes. Oncotarget (2016) 0.81
The transcription factor MEF2C negatively controls angiogenic sprouting of endothelial cells depending on oxygen. PLoS One (2014) 0.81
p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway. Mol Cell Biol (2015) 0.81
Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism (2016) 0.80
Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L. Oncotarget (2015) 0.80
ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy. J Ophthalmol (2010) 0.80
The wooly mutation (wly) on mouse chromosome 11 is associated with a genetic defect in Fam83g. BMC Res Notes (2013) 0.79
MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes Dev (2016) 0.78
Targeting MAPK Signaling in Age-Related Macular Degeneration. Ophthalmol Eye Dis (2016) 0.77
ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A (2016) 0.77
ERK5 Mediated Signalling in Diabetic Retinopathy. Med Hypothesis Discov Innov Ophthalmol (2015) 0.76
Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion. Circulation (2015) 0.76
Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Acta Crystallogr D Struct Biol (2016) 0.75
Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ. Nat Commun (2017) 0.75
Flow signaling and atherosclerosis. Cell Mol Life Sci (2016) 0.75
Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase. Cell Death Dis (2017) 0.75
Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298. Biochim Biophys Acta (2015) 0.75
Characterization of extracellular signal-regulated kinase 5 levels in human umbilical vein endothelial cells exposed to disturbed and uniform flow. Int J Angiol (2014) 0.75
Effects of Wenyangzhenshuai Granule on ERK1/2 and ERK5 activity in the myocardial tissue in a rabbit model of adriamycin-induced chronic heart failure. Int J Clin Exp Med (2015) 0.75
Role of extracellular signal-regulated kinase 5 in adipocyte signaling. J Biol Chem (2014) 0.75
Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494. Mol Ther Nucleic Acids (2017) 0.75
Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow. Int J Angiol (2017) 0.75
Statin Regulated ERK5 Stimulates Tight Junction Formation and Reduces Permeability in Human Cardiac Endothelial Cells. J Cell Physiol (2017) 0.75
Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Res (2017) 0.75
Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Sci Rep (2017) 0.75
Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells. PLoS One (2017) 0.75
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
Inducible gene targeting in mice. Science (1995) 21.22
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (1996) 16.92
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol (1995) 10.61
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem (1998) 8.30
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med (1995) 7.88
Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood (1998) 7.70
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell (1999) 7.33
Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol (1998) 7.31
Z/AP, a double reporter for cre-mediated recombination. Dev Biol (1999) 6.88
The extracellular matrix as a cell survival factor. Mol Biol Cell (1993) 6.32
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med (2001) 5.97
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet (1998) 5.95
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (2000) 5.62
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science (1997) 5.54
Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A (1991) 5.52
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J (1997) 4.51
Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest (2000) 4.33
Microvascular permeability. Physiol Rev (1999) 4.12
Components of a new human protein kinase signal transduction pathway. J Biol Chem (1995) 3.78
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem (1999) 3.76
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell (2000) 3.54
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem (1999) 3.42
Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat Neurosci (2001) 3.30
Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. J Biol Chem (2000) 3.30
Molecular biology of aging. Cell (1999) 3.08
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell (2000) 2.74
Requirement of the MADS-box transcription factor MEF2C for vascular development. Development (1998) 2.63
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature (1998) 2.62
Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res (2000) 2.60
Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem (1996) 2.51
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol Cell Biol (1996) 2.40
Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev (2003) 2.38
Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp Med (1996) 2.26
Isolation of MEK5 and differential expression of alternatively spliced forms. J Biol Chem (1995) 2.23
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest (1999) 2.22
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J (2001) 2.19
A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci U S A (2002) 2.16
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A (2002) 2.11
Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol (2000) 2.10
Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. Circ Res (2003) 1.96
Mekk3 is essential for early embryonic cardiovascular development. Nat Genet (2000) 1.95
c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1. J Biol Chem (1997) 1.71
The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol (1999) 1.71
Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res (2003) 1.66
Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. J Biol Chem (1999) 1.63
Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett (1999) 1.62
ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem (2002) 1.62
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci U S A (2003) 1.61
Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. J Biol Chem (2000) 1.57
Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc Natl Acad Sci U S A (2000) 1.52
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. EMBO Rep (2001) 1.51
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J Biol Chem (1999) 1.47
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. Am J Pathol (1997) 1.35
Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J Biol Chem (2002) 1.27
Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration. J Cell Sci (1999) 1.14
Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure. Hypertension (2003) 1.12
Multiple antioxidants in the prevention and treatment of Alzheimer disease: analysis of biologic rationale. Clin Neuropharmacol (2000) 0.87
Cancer. A radical approach to treatment. Nature (2000) 0.82
Diabetic cardiomyopathy revisited. Circulation (2007) 6.76
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation (2005) 3.22
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes (2007) 3.20
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol (2011) 2.91
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res (2008) 2.88
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res (2006) 2.85
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res (2012) 2.74
In situ kinase profiling reveals functionally relevant properties of native kinases. Chem Biol (2011) 2.69
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat Immunol (2004) 2.58
Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol (2003) 2.57
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest (2002) 2.53
Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology (2005) 2.43
Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes (2004) 2.39
Recipes for creating animal models of diabetic cardiovascular disease. Circ Res (2007) 2.34
Limiting inflammatory responses during activation of innate immunity. Nat Immunol (2005) 2.33
Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol (2007) 2.24
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature (2006) 2.17
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol (2007) 2.17
VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene (2003) 2.08
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. Science (2008) 1.93
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation (2009) 1.91
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem (2002) 1.86
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail (2006) 1.79
Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension (2009) 1.78
Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction. Am J Physiol Heart Circ Physiol (2003) 1.74
MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. J Biol Chem (2001) 1.74
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell (2010) 1.72
Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res (2013) 1.72
A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol (2005) 1.70
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol (2007) 1.67
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res (2008) 1.67
An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol (2010) 1.64
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. J Clin Invest (2010) 1.63
Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock (2009) 1.63
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res (2009) 1.60
Lipotoxicity in the heart. Biochim Biophys Acta (2009) 1.60
Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium. J Immunol (2002) 1.59
CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res (2009) 1.57
Rodent models of diabetic cardiomyopathy. Dis Model Mech (2009) 1.56
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes (2008) 1.55
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda) (2006) 1.53
Molecular mechanisms of diabetic cardiomyopathy. Diabetologia (2014) 1.53
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol (2008) 1.51
IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol (2002) 1.51
Mitochondria in the diabetic heart. Cardiovasc Res (2010) 1.50
Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol (2010) 1.50
Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice. J Mol Med (Berl) (2004) 1.48
Tenascin-C synthesized in both donor grafts and recipients accelerates artery graft stenosis. Cardiovasc Res (2007) 1.48
Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res (2009) 1.46
Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Am J Pathol (2005) 1.46
Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes (2009) 1.45
Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res (2003) 1.45
Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia. Proc Natl Acad Sci U S A (2007) 1.43
Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One (2011) 1.43
Akt1 in the cardiovascular system: friend or foe? J Clin Invest (2005) 1.43
The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology (2009) 1.43
The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol (2005) 1.42
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab (2007) 1.42
Toll-like receptor 9 mediates CpG-DNA signaling. J Leukoc Biol (2002) 1.42
N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. J Biol Chem (2006) 1.42
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond) (2008) 1.41
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Am J Physiol Heart Circ Physiol (2006) 1.41
Method of cell transplantation promoting the organization of intraarterial thrombus. Circulation (2005) 1.40
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer (2010) 1.39
Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther (2013) 1.38
IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. J Biol Chem (2003) 1.38
Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail (2012) 1.36
Structure-activity relationship of synthetic toll-like receptor 4 agonists. J Biol Chem (2003) 1.35
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol (2014) 1.35
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest (2010) 1.34
Co-stimulation of human breast cancer cells with transforming growth factor-beta and tenascin-C enhances matrix metalloproteinase-9 expression and cancer cell invasion. Int J Exp Pathol (2004) 1.33
Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis. Cancer Res (2005) 1.33
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol (2008) 1.33
Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy. Cardiovasc Res (2002) 1.33
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation. J Biol Chem (2003) 1.32
Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem (2006) 1.32
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res (2011) 1.31
MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. Am J Pathol (2003) 1.31
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes (2012) 1.31
Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res (2010) 1.30
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol (2009) 1.29
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol (2011) 1.27
Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. Carcinogenesis (2008) 1.27
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res (2013) 1.25
Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death. Exp Mol Med (2007) 1.24
Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma (2009) 1.23
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation (2008) 1.23
Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1. Int J Cancer (2003) 1.21