Published in EMBO J on December 01, 1997
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature (2000) 8.59
MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev (1998) 6.20
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc Natl Acad Sci U S A (2000) 4.27
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proc Natl Acad Sci U S A (2000) 4.08
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol Cell Biol (1999) 3.21
Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol (1999) 3.02
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest (2004) 2.76
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev (2010) 2.68
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol (1999) 2.36
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J (2001) 2.19
MAPK signalling: ERK5 versus ERK1/2. EMBO Rep (2006) 2.19
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol Cell Biol (2005) 2.18
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A (2002) 2.11
ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain. Mol Cell Biol (2000) 2.02
Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood (2009) 2.01
MEK and the inhibitors: from bench to bedside. J Hematol Oncol (2013) 1.90
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol (2000) 1.88
miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One (2009) 1.84
Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82
Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol (2000) 1.80
Osmotic stress induces rapid activation of a salicylic acid-induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells. Plant Cell (2000) 1.77
A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5. Mol Cell Biol (1999) 1.75
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell (2010) 1.72
Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2. Mol Cell Biol (2002) 1.64
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci U S A (2003) 1.61
Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc Natl Acad Sci U S A (2000) 1.52
Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol (2005) 1.51
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. EMBO Rep (2001) 1.51
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol (2008) 1.51
Differential localization of HDAC4 orchestrates muscle differentiation. Nucleic Acids Res (2001) 1.49
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
Phosphorylation meets nuclear import: a review. Cell Commun Signal (2010) 1.49
Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. Biochem Biophys Res Commun (2009) 1.46
Stress-activated protein kinases are negatively regulated by cell density. EMBO J (1998) 1.43
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. Genes Dev (2001) 1.41
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40
MEK5/ERK5 pathway: the first fifteen years. Biochim Biophys Acta (2011) 1.39
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Mol Cell Biol (2005) 1.38
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol Cell Biol (2005) 1.37
Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol (2003) 1.36
Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway. J Cell Biol (2007) 1.36
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol Cell Biol (2005) 1.34
Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol Cell Biol (1999) 1.31
ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation. J Biol Chem (2000) 1.30
Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30
MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol Cell Biol (2003) 1.29
Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol Cell Biol (2005) 1.27
Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J Biol Chem (2010) 1.25
Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol Biol Cell (2008) 1.20
Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. Mol Cell Biol (2006) 1.18
CARRIE web service: automated transcriptional regulatory network inference and interactive analysis. Nucleic Acids Res (2004) 1.18
Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D. Mol Cell Biol (2008) 1.18
Differential regulation of Tec1 by Fus3 and Kss1 confers signaling specificity in yeast development. Curr Genet (2004) 1.18
Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors. EMBO J (2000) 1.15
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev (2005) 1.13
Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Proc Natl Acad Sci U S A (2001) 1.12
A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol (2005) 1.12
Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem J (2002) 1.11
ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer (2011) 1.10
PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol (2006) 1.07
Vascular endothelial growth factor induces MEF2C and MEF2-dependent activity in endothelial cells. Invest Ophthalmol Vis Sci (2008) 1.06
MAP Kinases and Prostate Cancer. J Signal Transduct (2011) 1.06
Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction. Circ Res (2008) 1.05
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol Cell Biol (2001) 1.05
HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. Am J Respir Cell Mol Biol (2007) 1.05
Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. Biochem J (2002) 1.04
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res (2001) 1.04
Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate. Proc Natl Acad Sci U S A (2006) 1.03
Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol (2004) 1.03
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryot Cell (2006) 1.02
Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res (2011) 1.02
BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway. Cancer Res (2012) 1.01
Nuclear function of Smad7 promotes myogenesis. Mol Cell Biol (2009) 1.01
Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis. J Biol Chem (2012) 1.01
Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites. Mol Cell Biol (2005) 1.00
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol Cell Biol (2008) 1.00
ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis. PLoS One (2009) 0.99
ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. J Biol Chem (2009) 0.99
Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis. EMBO J (2008) 0.99
ERK5 promotes Src-induced podosome formation by limiting Rho activation. J Cell Biol (2008) 0.98
An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro. Biochem J (2003) 0.98
Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PLoS One (2012) 0.98
ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif. Biochem J (2004) 0.97
Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. J Mol Biol (2010) 0.97
Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology (2015) 0.97
Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis. J Biol Chem (2009) 0.96
MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells. Microcirculation (2011) 0.95
MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover. J Biol Chem (2009) 0.95
Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia. J Biol Chem (2009) 0.95
Activation of the MEF2 transcription factor in skeletal muscles from myotonic mice. J Clin Invest (2002) 0.95
Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells. Mol Endocrinol (2004) 0.94
Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J Neurosci (2014) 0.94
Myocyte enhancer factor 2A is transcriptionally autoregulated. J Biol Chem (2007) 0.92
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. Oncogene (2012) 0.92
Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer. Br J Cancer (2007) 0.92
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Mol Cell Biol (2006) 0.91
Requirement of the MEK5-ERK5 pathway for neural differentiation in Xenopus embryonic development. EMBO Rep (2005) 0.90
Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res (2014) 0.90
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76
The MAPK signaling cascade. FASEB J (1995) 10.81
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell (1994) 9.73
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54
The mitogen-activated protein kinase signal transduction pathway. J Biol Chem (1993) 8.77
Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science (1995) 7.37
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell (1993) 7.37
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science (1993) 7.00
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol (1996) 6.91
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (1996) 6.75
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell (1995) 6.24
Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci U S A (1993) 6.19
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature (1992) 5.69
Integration of MAP kinase signal transduction pathways at the serum response element. Science (1995) 5.45
Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature (1988) 5.18
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature (1997) 4.59
Parallel signal processing among mammalian MAPKs. Trends Biochem Sci (1995) 4.46
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J Cell Biol (1993) 4.24
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev (1992) 4.10
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science (1996) 4.03
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J (1995) 3.86
Components of a new human protein kinase signal transduction pathway. J Biol Chem (1995) 3.78
Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science (1995) 3.64
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem (1996) 3.63
Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem (1996) 3.63
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J (1995) 3.19
The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol (1991) 3.08
Induction of protooncogene c-jun by serum growth factors. Proc Natl Acad Sci U S A (1988) 2.92
Diversity in function and regulation of MAP kinase pathways. Trends Biochem Sci (1994) 2.70
Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A (1993) 2.53
Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem (1996) 2.51
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol Cell Biol (1993) 2.41
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol Cell Biol (1996) 2.40
A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol Cell Biol (1994) 2.30
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem (1996) 2.23
Isolation of MEK5 and differential expression of alternatively spliced forms. J Biol Chem (1995) 2.23
Primary structure of BMK1: a new mammalian map kinase. Biochem Biophys Res Commun (1995) 2.15
Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol (1995) 2.14
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A (1993) 2.07
Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol (1997) 2.07
Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol Cell Biol (1995) 1.93
The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway. Mol Cell Biol (1997) 1.89
Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin. Proc Natl Acad Sci U S A (1993) 1.55
MAP kinase binds to the NH2-terminal activation domain of c-Myc. FEBS Lett (1994) 1.21
MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells. Nucleic Acids Res (1995) 0.99
A potential role for c-jun in cell cycle progression through late G1 and S. Oncogene (1991) 0.98
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86
Toll-like receptors in the induction of the innate immune response. Nature (2000) 12.23
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science (1994) 10.99
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature (2003) 10.97
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (1995) 7.87
Structure and function of lipopolysaccharide binding protein. Science (1990) 7.76
Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology (1991) 7.33
The p38 signal transduction pathway: activation and function. Cell Signal (2000) 6.18
The effects of bacterial endotoxins on host mediation systems. A review. Am J Pathol (1978) 6.03
Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest (1988) 4.76
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature (1997) 4.59
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A (1993) 4.35
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol (2001) 4.13
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol (2000) 3.96
Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med (1986) 3.84
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem (1998) 3.80
CD14 is a pattern recognition receptor. Immunity (1994) 3.79
Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem (1996) 3.63
Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem (1996) 3.63
CD14: cell surface receptor and differentiation marker. Immunol Today (1993) 3.47
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol Cell Biol (1999) 3.21
The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J Immunol (1979) 3.09
Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol (1999) 3.02
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J Biol Chem (2001) 2.94
New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides. J Clin Invest (1979) 2.93
How we detect microbes and respond to them: the Toll-like receptors and their transducers. J Leukoc Biol (2003) 2.83
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med (1989) 2.72
Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway. J Exp Med (1992) 2.71
Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature (2001) 2.70
Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J Biol Chem (1989) 2.69
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature (1998) 2.62
Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem (1996) 2.51
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem (1997) 2.47
Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci U S A (2001) 2.46
Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade. Ann Rheum Dis (2008) 2.45
PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J (1998) 2.44
MicroRNA profile analysis of human prostate cancers. Cancer Gene Ther (2008) 2.43
Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV-infected, evaluated patients. Aliment Pharmacol Ther (2013) 2.38
The modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum. J Clin Invest (1978) 2.37
Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China). Nature (2001) 2.31
Family history of melanoma and Parkinson disease risk. Neurology (2009) 2.25
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev (2000) 2.21
Primary structure of BMK1: a new mammalian map kinase. Biochem Biophys Res Commun (1995) 2.15
Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages. J Clin Invest (1990) 2.12
Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials. Diabet Med (2010) 2.12
Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw (2000) 2.11
Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta (2001) 2.09
New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma. J Clin Invest (1981) 2.08
Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab (2006) 2.05
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J Exp Med (1992) 2.05
Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem (1998) 2.05
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity (1997) 2.04
Single photon emission computed tomography-EEG relations in temporal lobe epilepsy. Neurology (1997) 2.03
Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J Biol Chem (1995) 2.02
Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J Biol Chem (1989) 2.00
HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med (1996) 1.99
The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun (1996) 1.99
Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proc Natl Acad Sci U S A (1996) 1.97
Binding of bacterial peptidoglycan to CD14. J Biol Chem (1998) 1.97
The preparation and characterization of a radioiodinated bacterial lipopolysaccharide. Immunochemistry (1978) 1.95
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem (1993) 1.93
Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation. I. The role of complement. J Exp Med (1975) 1.91
Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. J Clin Invest (1998) 1.89
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol (2000) 1.88
Bronchial stenosis due to anthracofibrosis. Chest (1998) 1.87
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J Leukoc Biol (2000) 1.85
Ancestral echinoderms from the Chengjiang deposits of China. Nature (2004) 1.85
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J (1997) 1.84
Endoscopic removal of biliary self-expandable metallic stents: a prospective study. Endoscopy (2006) 1.83
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A (1997) 1.83
Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes. J Immunol (1992) 1.82
A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem (1988) 1.79
Head and backbone of the Early Cambrian vertebrate Haikouichthys. Nature (2003) 1.73