Published in J Neurochem on May 01, 2004
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
Tobacco addiction. Lancet (2008) 3.65
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev (2013) 2.42
Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem Pharmacol (2007) 2.18
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet (2006) 1.93
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A (2009) 1.76
Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proc Natl Acad Sci U S A (2009) 1.74
Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proc Natl Acad Sci U S A (2010) 1.63
Expansion of the human mu-opioid receptor gene architecture: novel functional variants. Hum Mol Genet (2008) 1.59
Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc Natl Acad Sci U S A (2008) 1.56
OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend (2010) 1.55
Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics (2010) 1.46
Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1. Biol Psychiatry (2015) 1.44
Stress, alcohol and drug interaction: an update of human research. Addict Biol (2008) 1.40
Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. Proc Natl Acad Sci U S A (2006) 1.37
Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Proc Natl Acad Sci U S A (2011) 1.29
Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. J Clin Invest (2012) 1.26
Searching for polymorphisms that affect gene expression and mRNA processing: example ABCB1 (MDR1). AAPS J (2006) 1.24
Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol Pain (2009) 1.24
Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain (2008) 1.22
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18
OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach. Alcohol Clin Exp Res (2008) 1.12
Opioid tolerance development: a pharmacokinetic/pharmacodynamic perspective. AAPS J (2008) 1.11
The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism. Sleep Med Rev (2012) 1.07
Functional characterization of human variants of the mu-opioid receptor gene. Proc Natl Acad Sci U S A (2009) 1.07
A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. Biochem J (2012) 1.06
The genetics of the opioid system and specific drug addictions. Hum Genet (2012) 1.04
Naltrexone alone and with sertraline for the treatment of alcohol dependence in Alaska natives and non-natives residing in rural settings: a randomized controlled trial. Alcohol Clin Exp Res (2008) 1.01
Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol Clin Exp Res (2009) 1.00
Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology (2008) 0.99
Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. Alcohol Clin Exp Res (2008) 0.98
Genetic influences on the dynamics of pain and affect in fibromyalgia. Health Psychol (2010) 0.97
Genetic contributions to pain: a review of findings in humans. Oral Dis (2008) 0.96
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Psychoneuroendocrinology (2011) 0.94
Symbiotic relationship of pharmacogenetics and drugs of abuse. AAPS J (2006) 0.93
The genetics of alcohol and other drug dependence. Alcohol Res Health (2008) 0.93
Child μ-opioid receptor gene variant influences parent-child relations. Neuropsychopharmacology (2011) 0.92
Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons. Anesthesiology (2011) 0.92
Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain. Eur J Clin Pharmacol (2013) 0.89
Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population. J Med Toxicol (2013) 0.88
A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides. J Neural Transm (Vienna) (2008) 0.88
Trial Protocol: Using genotype to tailor prescribing of nicotine replacement therapy: a randomised controlled trial assessing impact of communication upon adherence. BMC Public Health (2010) 0.88
Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. Cancer Epidemiol Biomarkers Prev (2009) 0.87
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet (2015) 0.86
micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Gut (2007) 0.86
Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside? J Pain Res (2013) 0.86
Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment. Addict Sci Clin Pract (2010) 0.85
Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation. Dev Psychopathol (2012) 0.84
No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample. Drug Alcohol Depend (2011) 0.84
Assessment of opioid receptor μ1 gene A118G polymorphism and its association with pain intensity in patients with fibromyalgia. Rheumatol Int (2014) 0.83
Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. Hum Genet (2011) 0.83
μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision. J Pain (2015) 0.82
Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.82
Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. PLoS One (2011) 0.81
Epigenetics: a promising paradigm for better understanding and managing pain. J Pain (2013) 0.81
Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1). Br J Pharmacol (2014) 0.81
Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates. Psychoneuroendocrinology (2008) 0.81
Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents. Pharmacogenomics J (2014) 0.81
μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption. Alcohol Alcohol (2013) 0.81
Elucidation of mu-Opioid Gene Structure: How Genetics Can Help Predict Responses to Opioids. Eur J Pain Suppl (2011) 0.80
Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects. Mol Brain (2013) 0.80
Analgesia and central side-effects: two separate dimensions of morphine response. Br J Clin Pharmacol (2013) 0.80
Chronic neuropathic pain in mice reduces μ-opioid receptor-mediated G-protein activity in the thalamus. Brain Res (2011) 0.80
Individualized pain medicine. Drug Discov Today Ther Strateg (2009) 0.79
Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice. Physiol Behav (2014) 0.79
Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism. Neuropsychopharmacology (2015) 0.78
Regional brain [(11)C]carfentanil binding following tobacco smoking. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.78
Buprenorphine signalling is compromised at the N40D polymorphism of the human μ opioid receptor in vitro. Br J Pharmacol (2014) 0.78
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. Pharmacol Biochem Behav (2012) 0.78
[Are polymorphisms in the mu-opioid receptor important for opioid therapy?]. Schmerz (2005) 0.78
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype. Neuropsychopharmacology (2016) 0.76
Opioid pharmacogenetics of alcohol addiction. Cold Spring Harb Perspect Med (2013) 0.76
Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G. Neuropsychopharmacology (2015) 0.76
Functional characteristics of the naked mole rat μ-opioid receptor. PLoS One (2013) 0.75
Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent. Pharmgenomics Pers Med (2012) 0.75
An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine. OMICS (2016) 0.75
Pharmacogenomic considerations in opioid analgesia. Pharmgenomics Pers Med (2012) 0.75
Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. Bosn J Basic Med Sci (2015) 0.75
A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology. Transl Psychiatry (2016) 0.75
Association between common genetic variants in the opioid pathway and smoking behaviors in Chinese men. Behav Brain Funct (2014) 0.75
The correlation between post-operative fentanyl requirements and μ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy. Exp Ther Med (2013) 0.75
Morphine-induced antinociception and reward in "humanized" mice expressing the mu opioid receptor A118G polymorphism. Brain Res Bull (2015) 0.75
DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. Pharmgenomics Pers Med (2017) 0.75
The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell (2010) 3.83
MEDSYNDIKATE--a natural language system for the extraction of medical information from findings reports. Int J Med Inform (2002) 2.70
Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women. Am J Clin Nutr (2006) 2.47
CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci (2003) 2.44
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev (2013) 2.42
Receptor endocytosis counteracts the development of opioid tolerance. Mol Pharmacol (2004) 2.36
Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists. J Nucl Med (2006) 2.23
Off label prescribing to children in primary care in Germany: retrospective cohort study. BMJ (2002) 1.88
Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J (2004) 1.77
Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron (2011) 1.76
The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol (2003) 1.73
Herbivore-induced volatiles induce the emission of ethylene in neighboring lima bean plants. Plant J (2002) 1.67
Role of receptor internalization in opioid tolerance and dependence. Pharmacol Ther (2007) 1.66
A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy. Ann Neurol (2002) 1.65
Trifunctional somatostatin-based derivatives designed for targeted radiotherapy using auger electron emitters. J Nucl Med (2005) 1.64
Glycemic load, glycemic index, and body mass index in Spanish adults. Am J Clin Nutr (2008) 1.56
Ecology, inhibitory activity, and morphogenesis of a marine antagonistic bacterium belonging to the Roseobacter clade. Appl Environ Microbiol (2005) 1.56
Discovery of complex mixtures of novel long-chain quorum sensing signals in free-living and host-associated marine alphaproteobacteria. Chembiochem (2005) 1.56
Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization. J Biol Chem (2002) 1.54
Comparison of a new self-gripping mesh with other fixation methods for laparoscopic hernia repair in a rat model. J Am Coll Surg (2009) 1.53
Composition of human skin microbiota affects attractiveness to malaria mosquitoes. PLoS One (2011) 1.47
A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial. PLoS One (2012) 1.46
[Body mass index in the prognosis of first myocardial infarction]. Med Clin (Barc) (2010) 1.43
Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice. Arthritis Res Ther (2011) 1.42
Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. Br J Pharmacol (2011) 1.40
Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization. J Biol Chem (2003) 1.40
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev (2005) 1.40
Volatiles released by a Streptomyces species isolated from the North Sea. Chem Biodivers (2005) 1.38
Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation. J Bacteriol (2007) 1.37
Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chembiochem (2004) 1.35
Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. J Comp Neurol (2008) 1.35
Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America. J Pediatr (2008) 1.35
Differential attraction of malaria mosquitoes to volatile blends produced by human skin bacteria. PLoS One (2010) 1.34
Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes. J Biol Chem (2004) 1.32
Creating knowledge repositories from biomedical reports: the MEDSYNDIKATE text mining system. Pac Symp Biocomput (2002) 1.31
Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. J Clin Endocrinol Metab (2008) 1.31
Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade. Org Biomol Chem (2009) 1.30
CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain. J Mol Endocrinol (2007) 1.30
Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain. J Neuroimmunol (2008) 1.27
Development of tolerance and sensitization to different opioid agonists in rats. Psychopharmacology (Berl) (2006) 1.27
Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon. J Comp Neurol (2007) 1.27
Somatostatin signaling in neuronal cilia is critical for object recognition memory. J Neurosci (2010) 1.23
Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab (2008) 1.23
Results of an Internet survey of myoelectric prosthetic hand users. Prosthet Orthot Int (2007) 1.20
Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling. J Biol Chem (2007) 1.18
Gene Regulation Ontology (GRO): design principles and use cases. Stud Health Technol Inform (2008) 1.18
Morphine-induced changes of gene expression in the brain. Addict Biol (2005) 1.18
Somatostatin receptor subtypes in human pheochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy. J Clin Endocrinol Metab (2003) 1.17
Biosynthesis of the off-flavor 2-methylisoborneol by the myxobacterium Nannocystis exedens. Angew Chem Int Ed Engl (2007) 1.16
Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues. Eur J Endocrinol (2010) 1.16
Comparing of IRS and Her2 as immunohistochemical scoring schemes in gastroenteropancreatic neuroendocrine tumors. Int J Clin Exp Pathol (2012) 1.15
Isosemantic rendering of clinical information using formal ontologies and RDF. Stud Health Technol Inform (2013) 1.15
Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors. J Clin Oncol (2008) 1.15
Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem (2007) 1.15
Evidence for regulation of resistance in Arabidopsis to Egyptian cotton worm by salicylic and jasmonic acid signaling pathways. Planta (2002) 1.14
Logic-based remodeling of the Digital Anatomist Foundational Model. AMIA Annu Symp Proc (2003) 1.14
PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. J Nucl Med (2011) 1.13
Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. Br J Pharmacol (2012) 1.13
Seed odor mediates an obligate ant-plant mutualism in Amazonian rainforests. Proc Natl Acad Sci U S A (2008) 1.13
Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation. J Comp Neurol (2004) 1.13
Submersion and asphyxial injury. Crit Care Med (2002) 1.12
Tropodithietic acid production in Phaeobacter gallaeciensis is regulated by N-acyl homoserine lactone-mediated quorum sensing. J Bacteriol (2011) 1.11
The @neurIST ontology of intracranial aneurysms: providing terminological services for an integrated IT infrastructure. AMIA Annu Symp Proc (2007) 1.11
Cross-language MeSH indexing using morpho-semantic normalization. AMIA Annu Symp Proc (2003) 1.11
Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2002) 1.11
New structural variants of homoserine lactones in bacteria. Chembiochem (2009) 1.11
Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus. J Neurosci (2008) 1.11
A large randomized individual and group intervention conducted by registered dietitians increased adherence to Mediterranean-type diets: the PREDIMED study. J Am Diet Assoc (2008) 1.10
Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation. Mol Endocrinol (2010) 1.10
A novel type of geosmin biosynthesis in myxobacteria. J Org Chem (2005) 1.10
Molecular imaging with ⁶⁸Ga-SSTR PET/CT and correlation to immunohistochemistry of somatostatin receptors in neuroendocrine tumours. Eur J Nucl Med Mol Imaging (2011) 1.10
The German specialist lexicon. Proc AMIA Symp (2002) 1.10
Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies. Clin Cancer Res (2004) 1.09
Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells. FASEB J (2006) 1.09
Towards a top-domain ontology for linking biomedical ontologies. Stud Health Technol Inform (2007) 1.09