Published in J Neurochem on May 01, 2004
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57
Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes. J Physiol (2006) 1.29
In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J Histochem Cytochem (2006) 1.25
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des (2012) 1.03
Nuclear membrane diversity: underlying tissue-specific pathologies in disease? Curr Opin Cell Biol (2015) 0.93
Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. J Cereb Blood Flow Metab (2009) 0.93
Role of ABC transporters in the pathogenesis of Alzheimer's disease. ACS Chem Neurosci (2012) 0.90
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
A new N-terminal recognition domain in caveolin-1 interacts with sterol carrier protein-2 (SCP-2). Biochemistry (2007) 0.86
Caveolin-1, caveolae, and glioblastoma. Neuro Oncol (2012) 0.86
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders. Brain Res (2015) 0.85
Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes. J Neurosci Res (2011) 0.84
Expression and clinical significance of multidrug resistance proteins in brain tumors. J Exp Clin Cancer Res (2010) 0.82
Transport and metabolism at blood-brain interfaces and in neural cells: relevance to bilirubin-induced encephalopathy. Front Pharmacol (2012) 0.82
ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation. PLoS One (2013) 0.81
Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels. J Neurochem (2015) 0.79
P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery. Adv Pharmacol (2014) 0.77
Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes. Neural Regen Res (2012) 0.76
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol (2009) 2.80
Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos (2008) 1.77
The complexities of antiretroviral drug-drug interactions: role of ABC and SLC transporters. Trends Pharmacol Sci (2009) 1.62
A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system. J Pharmacol Exp Ther (2006) 1.59
Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev (2007) 1.48
A new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells. Pharm Res (2006) 1.44
Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders. Pharm Res (2004) 1.38
Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol Rev (2006) 1.33
Localization and role of NPC1L1 in cholesterol absorption in human intestine. J Lipid Res (2006) 1.32
The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther (2004) 1.25
In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J Histochem Cytochem (2006) 1.25
Ethnic differences in drug metabolism and toxicity from chemotherapy. Expert Opin Drug Metab Toxicol (2009) 1.23
Chemotherapy dosing schedule influences drug resistance development in ovarian cancer. Mol Cancer Ther (2011) 1.21
Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther (2002) 1.20
Medicinal and recreational marijuana use by patients infected with HIV. AIDS Patient Care STDS (2004) 1.20
Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer. J Control Release (2006) 1.18
Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Adv Drug Deliv Rev (2009) 1.15
Use of complementary and alternative medicine by HIV-infected outpatients in Ontario, Canada. AIDS Patient Care STDS (2003) 1.14
Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line. J Neurosci Res (2009) 1.14
HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Mol Pharmacol (2006) 1.13
Regulation of drug transporters during infection and inflammation. Mol Interv (2007) 1.12
EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J Neurochem (2010) 1.07
HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells. J Neurochem (2008) 1.06
Functional expression of the multidrug resistance protein 1 in microglia. J Pharmacol Exp Ther (2003) 1.05
Localization, function and regulation of the two intestinal fatty acid-binding protein types. Histochem Cell Biol (2009) 1.04
Nanotechnological advances for the delivery of CNS therapeutics. Adv Drug Deliv Rev (2011) 1.03
Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways. Mol Pharmacol (2010) 1.03
Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos (2003) 1.03
Drug transport across the placenta, role of the ABC drug efflux transporters. Expert Opin Drug Metab Toxicol (2007) 1.02
Development of solid lipid nanoparticles containing ionically complexed chemotherapeutic drugs and chemosensitizers. J Pharm Sci (2004) 1.02
Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line. Pharm Res (2008) 1.02
Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. J Neurochem (2011) 1.00
Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer. Mol Cancer Ther (2008) 1.00
Expression of ATP-binding cassette membrane transporters in rodent and human sertoli cells: relevance to the permeability of antiretroviral therapy at the blood-testis barrier. J Pharmacol Exp Ther (2011) 1.00
Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia (2008) 0.99
Regulation of transporters by nuclear hormone receptors: implications during inflammation. Mol Pharm (2007) 0.98
Regulation of breast cancer resistant protein by peroxisome proliferator-activated receptor α in human brain microvessel endothelial cells. Mol Pharmacol (2012) 0.98
Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc Res Tech (2002) 0.98
Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. J Biol Chem (2002) 0.98
Caspase activation regulates the extracellular export of autophagic vacuoles. Autophagy (2012) 0.97
Polymeric drug delivery systems for localized cancer chemotherapy. Drug Deliv (2010) 0.96
Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. Pharm Res (2007) 0.96
Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br J Pharmacol (2003) 0.95
Endocrine and exocrine secretion of leptin by the gastric mucosa. J Histochem Cytochem (2005) 0.95
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia. J Pharmacol Exp Ther (2004) 0.95
Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats. Am J Physiol Gastrointest Liver Physiol (2007) 0.94
Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model. Cancer Chemother Pharmacol (2007) 0.94
Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Am J Physiol Renal Physiol (2008) 0.94
Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays. J Pharm Sci (2003) 0.93
Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver. Drug Metab Dispos (2007) 0.93
Impact of endotoxin-induced changes in P-glycoprotein expression on disposition of doxorubicin in mice. Drug Metab Dispos (2005) 0.93
Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response. Expert Rev Clin Pharmacol (2012) 0.92
Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression. Toxicology (2003) 0.92
Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract. Antimicrob Agents Chemother (2013) 0.91
Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer. Mol Pharm (2010) 0.91
Biocompatibility of injectable chitosan-phospholipid implant systems. Biomaterials (2009) 0.90
Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism. Drug Metab Dispos (2010) 0.90
Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa. Am J Physiol Gastrointest Liver Physiol (2005) 0.90
pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions. J Pharmacol Exp Ther (2010) 0.90
Transcytosis of gastric leptin through the rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol (2007) 0.90
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism. Prog Histochem Cytochem (2010) 0.89
A review on gastric leptin: the exocrine secretion of a gastric hormone. Anat Cell Biol (2012) 0.88
Circulating bile salt-dependent lipase originates from the pancreas via intestinal transcytosis. Gastroenterology (2003) 0.88
In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel. J Control Release (2005) 0.88
Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells. J Pharmacol Exp Ther (2012) 0.88
Longitudinal trends in antiretroviral use in a cohort of men and women in Ontario, Canada. AIDS Patient Care STDS (2006) 0.87
In vitro and in vivo evaluation of WK-X-34, a novel inhibitor of P-glycoprotein and BCRP, using radio imaging techniques. Int J Cancer (2006) 0.87
Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines. Pharm Res (2004) 0.87
Regulation of multidrug resistance by pro-inflammatory cytokines. Curr Cancer Drug Targets (2006) 0.86
Multidrug resistance protein 1-mediated transport of saquinavir by microglia. Neuroreport (2004) 0.86
Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors. J Control Release (2006) 0.86
Design and characterization of HER-2-targeted gold nanoparticles for enhanced X-radiation treatment of locally advanced breast cancer. Mol Pharm (2010) 0.86
Leptin biosynthetic pathway in white adipocytes. Biochem Cell Biol (2006) 0.85
Detection of P-glycoprotein activity in endotoxemic rats by 99mTc-sestamibi imaging. J Nucl Med (2005) 0.85
Apoptosis of tubular epithelial cells in glycogen nephrosis during diabetes. Lab Invest (2003) 0.85
"HIV isn't me…": HIV+ adolescents' experiences in a positive context of support and treatment. AIDS Care (2011) 0.85
Polypharmacy in HIV: impact of data source and gender on reported drug utilization. AIDS Patient Care STDS (2004) 0.85
Expression of membrane drug efflux transporters in the sigmoid colon of HIV-infected and uninfected men. J Clin Pharmacol (2013) 0.84
In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. Eur J Pharm Biopharm (2006) 0.84
Drug release mechanism of paclitaxel from a chitosan-lipid implant system: effect of swelling, degradation and morphology. Eur J Pharm Biopharm (2007) 0.84
Synthesis and physicochemical and dynamic mechanical properties of a water-soluble chitosan derivative as a biomaterial. Biomacromolecules (2006) 0.84
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. J Pharm Pharmacol (2003) 0.84
Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism. J Pharm Pharm Sci (2012) 0.84
Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes. J Neurosci Res (2011) 0.84
Receptor-Mediated Transcytosis of Leptin through Human Intestinal Cells In Vitro. Int J Cell Biol (2010) 0.84
The role of pregnane X receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice. Drug Metab Dispos (2005) 0.84
Ontogeny, immunolocalisation, distribution and function of SR-BI in the human intestine. J Cell Sci (2004) 0.84
Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes. FEBS Lett (2005) 0.84
Localization of P-glycoprotein at the nuclear envelope of rat brain cells. Biochem Biophys Res Commun (2007) 0.84
Clusterin expression in the early process of pancreas regeneration in the pancreatectomized rat. J Histochem Cytochem (2003) 0.83
An injectable depot system for sustained intraperitoneal chemotherapy of ovarian cancer results in favorable drug distribution at the whole body, peritoneal and intratumoral levels. J Control Release (2011) 0.82
Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancer. Mol Cancer Ther (2010) 0.82
Novel tetrahydroisoquinolin-ethyl-phenylamine based multidrug resistance inhibitors with broad-spectrum modulating properties. Cancer Chemother Pharmacol (2006) 0.82