PubRank

L Mario Amzel

Author PubWeight™ 80.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 2007 6.01
2 Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 2011 2.94
3 A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A 2009 2.85
4 Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex. Science 2004 2.57
5 Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature 2007 2.29
6 Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis. Structure 2007 1.67
7 The catalytic mechanism of peptidylglycine alpha-hydroxylating monooxygenase investigated by computer simulation. J Am Chem Soc 2006 1.49
8 Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 2003 1.48
9 Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins 2006 1.47
10 Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle 2008 1.35
11 Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell 2010 1.33
12 Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc Natl Acad Sci U S A 2007 1.27
13 The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate. Proc Natl Acad Sci U S A 2007 1.24
14 A novel fucose recognition fold involved in innate immunity. Nat Struct Biol 2002 1.22
15 Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase. Biochemistry 2002 1.21
16 Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis. Structure 2003 1.21
17 Structure and activity of the axon guidance protein MICAL. Proc Natl Acad Sci U S A 2005 1.13
18 Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2. Structure 2012 1.10
19 Structure and biological function of the RNA pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus. Structure 2009 1.10
20 Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition. Proc Natl Acad Sci U S A 2009 1.09
21 Na(+)/I(-) symporter activity requires a small and uncharged amino acid residue at position 395. Mol Endocrinol 2002 1.08
22 Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase. Biochemistry 2003 1.07
23 C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors. J Biol Chem 2005 1.07
24 Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. Am J Hum Genet 2007 1.05
25 A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease. Proteins 2004 1.02
26 Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nat Chem Biol 2009 1.02
27 Structure and mechanism of NAD[P]H:quinone acceptor oxidoreductases (NQO). Methods Enzymol 2004 1.02
28 Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife 2013 1.02
29 Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS). Proc Natl Acad Sci U S A 2011 0.99
30 Hydrogen bonding at a conserved threonine in lentivirus capsid is required for virus replication. J Virol 2003 0.99
31 Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family. J Bacteriol 2003 0.98
32 The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role. Biophys J 2005 0.97
33 Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme. Structure 2009 0.96
34 Mechanism of titin unfolding by force: insight from quasi-equilibrium molecular dynamics calculations. Biophys J 2006 0.96
35 Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review). Mol Membr Biol 2003 0.96
36 Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Nucleic Acids Res 2006 0.95
37 Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase. J Am Chem Soc 2010 0.94
38 Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins 2010 0.93
39 Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity. Dev Comp Immunol 2011 0.93
40 Direct activation of Epac by sulfonylurea is isoform selective. Chem Biol 2011 0.91
41 Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase. J Bacteriol 2008 0.91
42 Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis elegans: binding to blood group precursor oligosaccharides (type 1, type 2, Talpha, and Tbeta) and gangliosides. Glycobiology 2002 0.89
43 Tuberculosis drug targets. Curr Drug Targets 2002 0.88
44 Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus. Structure 2004 0.88
45 Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase. Biochemistry 2002 0.87
46 Structural effects of oncogenic PI3Kα mutations. Curr Top Microbiol Immunol 2010 0.87
47 Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry 2010 0.85
48 Role of entropy in increased rates of intramolecular reactions. J Am Chem Soc 2003 0.85
49 Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. J Med Chem 2012 0.84
50 Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects. Ann N Y Acad Sci 2012 0.84
51 NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region. J Biol Chem 2010 0.84
52 Structure, function, and mechanism of cytosolic quinone reductases. Vitam Horm 2008 0.84
53 The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor. Structure 2011 0.83
54 Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS). FASEB J 2013 0.83
55 Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. Biochim Biophys Acta 2009 0.82
56 Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase. Adv Enzyme Regul 2010 0.81
57 Disaccharide binding to galectin-1: free energy calculations and molecular recognition mechanism. Biophys J 2011 0.80
58 The Nudix hydrolase CDP-chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities. J Bacteriol 2011 0.80
59 Loss of translational entropy in molecular associations. Proteins 2004 0.80
60 Coordination of peroxide to the Cu(M) center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study. J Biol Inorg Chem 2012 0.80
61 Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins 2011 0.80
62 Helix propensities calculations for amino acids in alanine based peptides using Jarzynski's equality. Proteins 2010 0.79
63 Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. Biochemistry 2005 0.79
64 Structure and specificity of a binary tandem domain F-lectin from striped bass (Morone saxatilis). J Mol Biol 2010 0.78
65 Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem 2013 0.77
66 Estimation of free-energy differences from computed work distributions: an application of Jarzynski's equality. J Phys Chem B 2012 0.77
67 Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem 2013 0.77
68 A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis. PLoS One 2013 0.76
69 X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction. Biochemistry 2006 0.76
70 Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies. J Mol Biol 2013 0.75
71 Making the right moves. Structure 2007 0.75