Published in Proc Natl Acad Sci U S A on February 04, 2009
Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci (2013) 1.82
The neurobiology of D-amino acid oxidase and its involvement in schizophrenia. Mol Psychiatry (2009) 1.12
Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci (2010) 1.10
Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane. Proc Natl Acad Sci U S A (2009) 1.02
Cell-type specific mechanisms of D-serine uptake and release in the brain. Front Synaptic Neurosci (2014) 0.89
Phylogenetic Profiles Reveal Structural and Functional Determinants of Lipid-binding. J Proteomics Bioinform (2009) 0.86
Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem (2012) 0.86
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO). J Neurosci Res (2010) 0.84
Roles of quaternary structure and cysteine residues in the activity of human serine racemase. BMC Biochem (2011) 0.83
D-Serine: a key to synaptic plasticity? Int J Biochem Cell Biol (2012) 0.80
Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidase. J Neurophysiol (2013) 0.79
FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. J Biol Chem (2014) 0.78
Serine racemase: a key player in apoptosis and necrosis. Front Synaptic Neurosci (2014) 0.78
Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk. J Biol Chem (2014) 0.77
Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes. Proc Natl Acad Sci U S A (2015) 0.77
Adaptive GDDA-BLAST: fast and efficient algorithm for protein sequence embedding. PLoS One (2010) 0.76
Nuclear Compartmentalization of Serine Racemase Regulates d-Serine Production: IMPLICATIONS FOR N-METHYL-d-ASPARTATE (NMDA) RECEPTOR ACTIVATION. J Biol Chem (2015) 0.76
Latest developments in experimental and computational approaches to characterize protein-lipid interactions. Proteomics (2012) 0.75
D-Amino Acids in the Nervous and Endocrine Systems. Scientifica (Cairo) (2016) 0.75
MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae. PLoS Genet (2017) 0.75
Plasma membrane phosphoinositide organization by protein electrostatics. Nature (2005) 6.32
PIP(2) and proteins: interactions, organization, and information flow. Annu Rev Biophys Biomol Struct (2001) 5.66
Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell (2006) 4.53
The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE (2001) 4.45
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A (1995) 3.51
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A (1999) 3.15
NMDA receptor pathways as drug targets. Nat Neurosci (2002) 2.20
Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A (2005) 2.06
Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors. J Biol Chem (2006) 1.95
Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry (2008) 1.88
Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J Neurochem (1993) 1.78
Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A (2005) 1.68
D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration. FEBS J (2008) 1.63
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. Proc Natl Acad Sci U S A (2002) 1.32
D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices. J Neurosci (2005) 1.28
Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc Natl Acad Sci U S A (2007) 1.27
Phylogenetic profiles reveal evolutionary relationships within the "twilight zone" of sequence similarity. Proc Natl Acad Sci U S A (2008) 1.11
Molecular determinants of D-serine-mediated gliotransmission: from release to function. Glia (2006) 1.00
Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo. Eur J Pharmacol (2006) 0.99
D-Serine as a putative glial neurotransmitter. Neuron Glia Biol (2004) 0.94
Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase. J Biol Chem (2006) 0.94
TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion. J Biol Chem (2008) 0.92
Defining the role of astrocytes in neuromodulation. Neuron (2007) 0.92
Astrocytes control neuronal excitability in the nucleus accumbens. ScientificWorldJournal (2007) 0.88
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science (2007) 6.01
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol (2003) 5.28
H2S signals through protein S-sulfhydration. Sci Signal (2009) 4.54
Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci U S A (2002) 4.38
Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics (2004) 3.54
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Mol Cell (2007) 3.44
The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol (2002) 3.40
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34
Phosphorylation of proteins by inositol pyrophosphates. Science (2004) 3.27
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell (2012) 3.26
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes Dev (2007) 3.08
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science (2005) 3.05
Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem (2004) 2.95
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res (2011) 2.94
Novel neural modulators. Annu Rev Neurosci (2003) 2.91
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A (2009) 2.85
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. Mol Cell (2005) 2.81
Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg (2008) 2.79
Signaling by gasotransmitters. Sci Signal (2009) 2.66
H₂S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol (2012) 2.59
Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex. Science (2004) 2.57
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation. Hum Mol Genet (2003) 2.50
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science (2009) 2.39
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31
Hydrogen sulfide as a gasotransmitter. J Neurochem (2010) 2.30
Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature (2007) 2.29
Development and characterization of a reconstituted yeast translation initiation system. RNA (2002) 2.27
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab (2011) 2.24
GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol (2010) 2.22
Schizophrenia: diverse approaches to a complex disease. Science (2002) 2.20
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06
H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A (2010) 2.04
N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. EMBO J (2007) 2.03
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci U S A (2009) 1.96
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2002) 1.96
Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science (2006) 1.95
Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94
Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83
NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron (2006) 1.83
Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol (2012) 1.79
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci U S A (2002) 1.76
Nitric oxide-GAPDH-Siah: a novel cell death cascade. Cell Mol Neurobiol (2006) 1.75
Cell signaling and neuronal death. Annu Rev Pharmacol Toxicol (2007) 1.75
A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell (2006) 1.75
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases. Proc Natl Acad Sci U S A (2005) 1.75
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nat Neurosci (2011) 1.74
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74
S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron (2005) 1.73
Akt as a mediator of cell death. Proc Natl Acad Sci U S A (2003) 1.73
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71
Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci U S A (2002) 1.69
Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A (2005) 1.68
Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis. Structure (2007) 1.67
Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A (2006) 1.66
Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Cell (2002) 1.64
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem (2004) 1.63
D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Proc Natl Acad Sci U S A (2003) 1.57
Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease. J Neurosci (2013) 1.55
Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell (2008) 1.52
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A (2012) 1.50
The catalytic mechanism of peptidylglycine alpha-hydroxylating monooxygenase investigated by computer simulation. J Am Chem Soc (2006) 1.49
Sulfhydration mediates neuroprotective actions of parkin. Nat Commun (2013) 1.49
Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron (2003) 1.48
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins (2006) 1.47
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem (2004) 1.47
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A (2008) 1.46
A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A (2005) 1.42
Heme oxygenase-2 is activated by calcium-calmodulin. J Biol Chem (2004) 1.41
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2008) 1.39
Inositol pyrophosphates as mammalian cell signals. Sci Signal (2011) 1.38
S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron (2011) 1.35
Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle (2008) 1.35