Published in Oncogene on June 24, 2004
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res (2009) 2.07
Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr Rev (2008) 1.18
An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling. EMBO J (2008) 1.13
TGF-beta signaling in chondrocytes. Front Biosci (2005) 1.08
Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation. J Appl Physiol (1985) (2011) 1.06
TGF-β signaling in C. elegans. WormBook (2013) 0.99
Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. J Biol Chem (2013) 0.94
Key role for ubiquitin protein modification in TGFβ signal transduction. Ups J Med Sci (2012) 0.90
The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7. J Biol Chem (2009) 0.87
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem (2011) 0.87
The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun (2009) 0.85
Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-β signaling. J Biol Chem (2014) 0.84
Retracted Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy. Cell Mol Life Sci (2014) 0.84
The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease. Haematologica (2014) 0.84
ZAS3 accentuates transforming growth factor β signaling in epithelial cells. Cell Signal (2010) 0.79
Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer. Virology (2013) 0.77
SETBP1 dysregulation in congenital disorders and myeloid neoplasms. Oncotarget (2017) 0.75
Modulation of microRNA processing by p53. Nature (2009) 7.88
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell (2007) 2.92
Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells (2002) 2.85
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell (2009) 2.79
Roles of TGF-beta family signaling in stem cell renewal and differentiation. Cell Res (2009) 2.74
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Mol Cell (2011) 2.38
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci U S A (2007) 2.30
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J Natl Cancer Inst (2005) 2.23
miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation. Biochem Biophys Res Commun (2008) 2.16
Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol (2004) 2.11
Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci (2008) 2.09
Id: a target of BMP signaling. Sci STKE (2002) 2.03
Systematic expression profiling of the mouse transcriptome using RIKEN cDNA microarrays. Genome Res (2003) 1.98
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. J Cell Sci (2007) 1.94
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem (2008) 1.88
Role of Ras signaling in the induction of snail by transforming growth factor-beta. J Biol Chem (2008) 1.83
RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr Opin Genet Dev (2003) 1.80
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol Biol Cell (2003) 1.78
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J (2004) 1.77
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol (2008) 1.77
c-myc is a downstream target of the Smad pathway. J Biol Chem (2001) 1.74
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J (2011) 1.71
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J (2003) 1.68
The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci (2005) 1.67
TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol (2003) 1.66
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem (2003) 1.65
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. J Biochem (2011) 1.61
The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Res (2003) 1.61
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J Cell Sci (2005) 1.61
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J Biol Chem (2002) 1.61
Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J Cell Physiol (2002) 1.61
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J Biol Chem (2005) 1.60
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum (2006) 1.59
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res (2011) 1.55
Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. Cancer Res (2009) 1.55
Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer (2003) 1.54
Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood (2008) 1.52
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes Cells (2002) 1.51
Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. Blood (2009) 1.50
TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. J Biochem (2011) 1.46
miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. FEBS Lett (2009) 1.46
Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells. Cancer Res (2009) 1.45
Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci (2007) 1.45
Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell (2002) 1.45
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell (2007) 1.44
Overexpression of the transcription factor Yin-Yang-1 suppresses differentiation of HaCaT cells in three-dimensional cell culture. J Invest Dermatol (2010) 1.44
BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci (2010) 1.43
miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. Blood (2011) 1.43
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene (2004) 1.42
TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity. J Biochem (2008) 1.41
Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem (2007) 1.40
Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury. J Gastroenterol (2004) 1.38
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. J Biol Chem (2007) 1.35
c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci (2007) 1.33
Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Res (2003) 1.32
Emerging complexity of microRNA generation cascades. J Biochem (2010) 1.32
Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes. J Invest Dermatol (2010) 1.31
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice. J Cell Sci (2007) 1.31
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol Cell (2010) 1.30
Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo. J Cell Biol (2009) 1.25
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. J Biol Chem (2008) 1.24
BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling. J Biochem (2007) 1.24
Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta. Oncogene (2004) 1.23
COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes Cells (2009) 1.22
Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis. Cancer Res (2007) 1.21
Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res (2007) 1.21
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochem Biophys Res Commun (2004) 1.20
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol (2006) 1.20
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta. Mol Cell Biol (2005) 1.20
A crucial role of a high mobility group protein HMGA2 in cardiogenesis. Nat Cell Biol (2008) 1.19
Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol (2004) 1.19
Promoter-wide analysis of Smad4 binding sites in human epithelial cells. Cancer Sci (2009) 1.18
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res (2003) 1.18
Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus. Development (2003) 1.16
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J Biol Chem (2009) 1.16
Cellular context-dependent "colors" of transforming growth factor-beta signaling. Cancer Sci (2009) 1.16
BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells. Oncogene (2004) 1.15
Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors. J Biol Chem (2007) 1.15
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. Cancer Sci (2007) 1.14