Published in Am J Physiol Lung Cell Mol Physiol on July 30, 2004
Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest (2012) 2.59
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Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. Am J Respir Crit Care Med (2009) 2.40
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem (2007) 1.99
Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol (2007) 1.85
Echocardiography in translational research: of mice and men. J Am Soc Echocardiogr (2008) 1.84
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation (2012) 1.75
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation (2008) 1.72
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol (2009) 1.65
Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production. A Gateway to Pulmonary Arterial Hypertension. Am J Respir Crit Care Med (2015) 1.53
A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol (2007) 1.51
Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension. Am J Respir Crit Care Med (2008) 1.37
TGFβ signaling and cardiovascular diseases. Int J Biol Sci (2012) 1.35
Bone Morphogenetic Protein (BMP) signaling in development and human diseases. Genes Dis (2014) 1.27
BMP signaling in vascular development and disease. Cytokine Growth Factor Rev (2010) 1.26
Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis. Bone (2012) 1.25
Idiopathic pulmonary arterial hypertension. Dis Model Mech (2010) 1.09
Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circ Res (2007) 1.06
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med (2013) 1.05
Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol (2009) 1.02
Vascular remodeling in pulmonary hypertension. J Mol Med (Berl) (2013) 1.02
The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem (2009) 1.01
The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice. J Exp Med (2009) 0.98
Dysfunctional intracellular trafficking in the pathobiology of pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2007) 0.96
BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ (2012) 0.95
A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet? Pulm Circ (2013) 0.94
BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1. Arterioscler Thromb Vasc Biol (2009) 0.92
Structure and composition of pulmonary arteries, capillaries, and veins. Compr Physiol (2012) 0.91
Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension. Am J Respir Cell Mol Biol (2010) 0.90
Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors. PLoS One (2013) 0.90
The role of collagen synthesis in ventricular and vascular adaptation to hypoxic pulmonary hypertension. J Biomech Eng (2013) 0.89
Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates. Semin Cell Dev Biol (2011) 0.88
The genetics of pulmonary arterial hypertension in the post-BMPR2 era. Pulm Circ (2011) 0.87
Life is a pattern: vascular assembly within the embryo. Front Biosci (Elite Ed) (2012) 0.86
BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism. Blood (2014) 0.84
Pericytes as targets in hereditary hemorrhagic telangiectasia. Front Genet (2015) 0.84
Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med (2016) 0.84
Krüppel-like factor 15 regulates BMPER in endothelial cells. Cardiovasc Res (2009) 0.84
A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension. J Biol Chem (2013) 0.84
Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation. J Cell Physiol (2012) 0.83
A process-based review of mouse models of pulmonary hypertension. Pulm Circ (2012) 0.82
Heart failure and pulmonary hypertension. Heart Fail Clin (2010) 0.82
Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension. PLoS One (2013) 0.82
Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol (2015) 0.82
Hemodynamic and histologic characterization of a swine (Sus scrofa domestica) model of chronic pulmonary arterial hypertension. Comp Med (2011) 0.82
Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function. PLoS One (2013) 0.81
Molecular pathogenesis and current pathology of pulmonary hypertension. Heart Fail Rev (2016) 0.80
Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Pulm Circ (2015) 0.80
Vascular histomolecular analysis by sequential endoarterial biopsy in a shunt model of pulmonary hypertension. Pulm Circ (2013) 0.77
BMPRII influences the response of pulmonary microvascular endothelial cells to inflammatory mediators. Pflugers Arch (2016) 0.76
Toward systems biology of pulmonary hypertension. Circulation (2012) 0.76
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun (2017) 0.75
BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions. PLoS One (2015) 0.75
Genotype-phenotype effects of Bmpr2 mutations on disease severity in mouse models of pulmonary hypertension. Pulm Circ (2016) 0.75
Three novel BMPR2 mutations associated with advanced pulmonary arterial hypertension. Hum Genome Var (2017) 0.75
Challenges in the development of chronic pulmonary hypertension models in large animals. Pulm Circ (2017) 0.75
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
Third universal definition of myocardial infarction. J Am Coll Cardiol (2012) 8.59
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
Modulation of microRNA processing by p53. Nature (2009) 7.88
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol (2003) 5.27
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci (2010) 5.12
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development (2002) 4.72
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40
DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38
BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med (2008) 4.20
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet (2007) 3.63
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A (2005) 3.52
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem (2002) 3.50
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet (2007) 3.27
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A (2012) 3.03
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature (2009) 2.98
Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell (2007) 2.92
Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92
Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells (2002) 2.85
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell (2009) 2.79
Roles of TGF-beta family signaling in stem cell renewal and differentiation. Cell Res (2009) 2.74
Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation (2007) 2.58
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A (2003) 2.54
Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. RNA (2005) 2.51
Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett (2008) 2.51
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50
Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol (2006) 2.48
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res (2005) 2.42
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Mol Cell (2011) 2.38
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci U S A (2007) 2.30
The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol (2004) 2.30
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circ Res (2004) 2.29
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J Natl Cancer Inst (2005) 2.23
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci U S A (2004) 2.21
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem (2004) 2.15
Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J (2002) 2.13
Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol (2004) 2.11
Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem (2005) 2.10
Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci (2008) 2.09
DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development (2006) 2.08
Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice. Circulation (2009) 2.05
Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension. Circ Cardiovasc Imaging (2009) 2.05
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem (2005) 2.04
Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation (2006) 2.04
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res (2006) 2.02
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell (2008) 1.99
Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One (2008) 1.99
Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury. Eur Heart J (2006) 1.98
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. J Cell Sci (2007) 1.94
Structure and function of eukaryotic DNA methyltransferases. Curr Top Dev Biol (2004) 1.91
RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. RNA (2006) 1.89
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem (2008) 1.88
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice. Neurobiol Dis (2002) 1.84
The rise of oxygen over the past 205 million years and the evolution of large placental mammals. Science (2005) 1.84
Role of Ras signaling in the induction of snail by transforming growth factor-beta. J Biol Chem (2008) 1.83
RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr Opin Genet Dev (2003) 1.80
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation. Gene (2002) 1.80
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol Biol Cell (2003) 1.78
Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology (2008) 1.77
Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J (2004) 1.77
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol (2008) 1.77
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76
Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation (2009) 1.75
Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology (2011) 1.74
c-myc is a downstream target of the Smad pathway. J Biol Chem (2001) 1.74
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation (2008) 1.72
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J (2011) 1.71
Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH. Proc Natl Acad Sci U S A (2013) 1.68
Handoffs causing patient harm: a survey of medical and surgical house staff. Jt Comm J Qual Patient Saf (2008) 1.68
Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev (2002) 1.68
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J (2003) 1.68
The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci (2005) 1.67