Published in Int J Biochem Cell Biol on July 01, 2004
Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol (2005) 2.98
Inflammatory lipid mediators in adipocyte function and obesity. Nat Rev Endocrinol (2010) 1.87
Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res (2007) 1.83
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2008) 1.59
Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am J Respir Cell Mol Biol (2009) 1.28
Current concepts regarding the pathogenesis of necrotizing enterocolitis. Pediatr Surg Int (2009) 1.21
Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Development (2008) 1.19
Attenuation of diabetes-induced retinal vasoconstriction by a thromboxane receptor antagonist. Exp Eye Res (2008) 1.11
Endothelium-dependent contractions: when a good guy turns bad! J Physiol (2008) 1.08
Urinary prostaglandin E2 metabolite and risk for colorectal adenoma. Cancer Prev Res (Phila) (2011) 1.08
How it's made: organisational effects of hormones on the developing brain. J Neuroendocrinol (2010) 1.02
PPARgamma and MEK Interactions in Cancer. PPAR Res (2008) 1.02
cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. J Physiol (2007) 1.02
Mechanotransduction in skeletal muscle. Front Biosci (2007) 1.01
Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP-induced release of PGE2. J Physiol (2008) 1.01
Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells. Int J Cancer (2007) 1.00
Cellular mechanisms of estradiol-mediated sexual differentiation of the brain. Trends Endocrinol Metab (2010) 0.95
Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells. Br J Cancer (2008) 0.94
Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci U S A (2007) 0.94
PGE(2) is a UVR-inducible autocrine factor for human melanocytes that stimulates tyrosinase activation. Exp Dermatol (2010) 0.93
Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration. Prostaglandins Leukot Essent Fatty Acids (2010) 0.92
Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells. Atherosclerosis (2007) 0.92
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. Adv Nutr (2015) 0.91
Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity. Neurotoxicology (2011) 0.91
Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells. Br J Clin Pharmacol (2007) 0.89
Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier. J Neuroimmune Pharmacol (2012) 0.89
Targeting the eicosanoid pathway in non-small-cell lung cancer. Expert Opin Ther Targets (2009) 0.88
Prostaglandin E2 regulates melanocyte dendrite formation through activation of PKCzeta. Exp Cell Res (2007) 0.88
Pathogenesis of neonatal necrotizing enterocolitis. Pediatr Surg Int (2015) 0.86
Resetting of peripheral circadian clock by prostaglandin E2. EMBO Rep (2005) 0.86
Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling. Mol Biol Cell (2012) 0.86
The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. J Neurochem (2011) 0.86
GRP78 is a novel receptor initiating a vascular barrier protective response to oxidized phospholipids. Mol Biol Cell (2014) 0.86
Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells. J Biol Chem (2014) 0.85
The emerging role of oxylipins in thrombosis and diabetes. Front Pharmacol (2014) 0.85
HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration. Br J Pharmacol (2015) 0.83
Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-κB Pathways in Nasal Polyp-Derived Fibroblasts. Allergy Asthma Immunol Res (2014) 0.83
Metabolic actions of angiotensin II and insulin: a microvascular endothelial balancing act. Mol Cell Endocrinol (2012) 0.82
Multiple roles of the PGE2 -EP receptor signal in vascular permeability. Br J Pharmacol (2014) 0.82
Effects of prostaglandin analogues on aqueous humor outflow pathways. J Ocul Pharmacol Ther (2013) 0.81
TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent. Biochim Biophys Acta (2009) 0.81
Three paradigms of airway smooth muscle hyperresponsiveness in young guinea pigs. Can J Physiol Pharmacol (2007) 0.81
Effect of prostaglandin I2 analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation. Mol Med (2012) 0.81
Angiogenesis in the primate ovulatory follicle is stimulated by luteinizing hormone via prostaglandin E2. Biol Reprod (2014) 0.81
Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. J Clin Endocrinol Metab (2014) 0.81
Thromboxane A(2) modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells. Exp Mol Med (2009) 0.80
Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts. Am J Respir Cell Mol Biol (2013) 0.80
Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ (2012) 0.80
Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6. Am J Respir Cell Mol Biol (2015) 0.79
Prostaglandin E2 and vascular endothelial growth factor A mediate angiogenesis of human ovarian follicular endothelial cells. Hum Reprod (2016) 0.79
11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females. Fertil Steril (2012) 0.79
Cyclic AMP-mediated chloride secretion is induced by prostaglandin F2alpha in human isolated colon. Br J Pharmacol (2009) 0.79
The involvement of central cholinergic system in the pressor effect of intracerebroventricularly injected U-46619, a thromboxane A2 analog, in conscious normotensive rats. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.79
Endocardial endothelium is a key determinant of force-frequency relationship in rat ventricular myocardium. J Appl Physiol (1985) (2013) 0.79
Nitric oxide and ERK/MAPK mediation of estrous behavior induced by GnRH, PGE2 and db-cAMP in rats. Physiol Behav (2009) 0.78
Prostaglandins temporally regulate cytoplasmic actin bundle formation during Drosophila oogenesis. Mol Biol Cell (2013) 0.78
Prostaglandin E2 excitatory effects on guinea pig urinary bladder smooth muscle: a novel regulatory mechanism mediated by large-conductance voltage- and Ca2+-activated K+ channels. Eur J Pharmacol (2014) 0.78
Methamphetamine effects on blood-brain barrier structure and function. Front Neurosci (2015) 0.78
Stretch-induced ERK2 phosphorylation requires PLA2 activity in skeletal myotubes. Biochem Biophys Res Commun (2009) 0.77
Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway. Clin Exp Immunol (2010) 0.77
Intermolecular cross-talk between the prostaglandin E2 receptor (EP)3 of subtype and thromboxane A(2) receptor signalling in human erythroleukaemic cells. Br J Pharmacol (2009) 0.76
Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts. Am J Respir Cell Mol Biol (2012) 0.76
PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation. Biochem Biophys Res Commun (2009) 0.75
EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells. Biomol Ther (Seoul) (2015) 0.75
Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome. Exp Ther Med (2017) 0.75
Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection. Med Microbiol Immunol (2015) 0.75
Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. Lab Invest (2013) 0.75
Role of Urinary Biomarkers in the Diagnosis of Adenoma and Colorectal Cancer: A Systematic Review and Meta-Analysis. J Cancer (2016) 0.75
Administration of prostacyclin modulates cutaneous blood flow but not sweating in young and older males: roles for nitric oxide and calcium-activated potassium channels. J Physiol (2016) 0.75
Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. J Neuroinflammation (2017) 0.75
Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Spermatogenesis (2015) 0.75
The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction. J Biomed Sci (2013) 0.75
Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology. Front Biosci (Landmark Ed) (2016) 0.75
Analgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists. Pharmacol Res Perspect (2017) 0.75
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73
Patterns of recurrence after surgery alone versus preoperative chemoradiotherapy and surgery in the CROSS trials. J Clin Oncol (2014) 4.59
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology (2003) 3.41
High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer. N Engl J Med (2003) 3.15
The risk of cancer in users of statins. J Clin Oncol (2004) 3.01
The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol (2012) 2.83
Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci U S A (2006) 2.65
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet (2004) 2.59
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol (2006) 2.45
Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease. Gut (2006) 2.41
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol (2006) 2.35
Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients. J Clin Oncol (2006) 2.33
The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol (2005) 2.31
Fatigue and relating factors in high-risk breast cancer patients treated with adjuvant standard or high-dose chemotherapy: a longitudinal study. J Clin Oncol (2005) 2.14
Epidemiology of cancer-associated venous thrombosis. Blood (2013) 2.00
Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry (2006) 1.99
Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology (2004) 1.92
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta (2010) 1.85
Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat Rev (2004) 1.84
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell (2011) 1.80
Kinetics of salicylate-mediated suppression of jasmonate signaling reveal a role for redox modulation. Plant Physiol (2008) 1.78
Validity of bioluminescence measurements for noninvasive in vivo imaging of tumor load in small animals. Biotechniques (2007) 1.66
Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease. Sci Transl Med (2014) 1.64
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. Gastroenterology (2008) 1.61
Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling. Plant Physiol (2009) 1.61
The relationship between tissue factor and cancer progression: insights from bench and bedside. Blood (2011) 1.61
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. J Immunol (2002) 1.51
Hedgehog signalling as an antagonist of ageing and its associated diseases. Bioessays (2012) 1.50
Cardiotoxicity of cytotoxic drugs. Cancer Treat Rev (2004) 1.48
Salicylate-mediated suppression of jasmonate-responsive gene expression in Arabidopsis is targeted downstream of the jasmonate biosynthesis pathway. Planta (2010) 1.47
Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. J Immunol (2004) 1.45
Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer Res (2007) 1.44
Validation of serum amyloid α as an independent biomarker for progression-free and overall survival in metastatic renal cell cancer patients. Eur Urol (2012) 1.41
Salicylic acid suppresses jasmonic acid signaling downstream of SCFCOI1-JAZ by targeting GCC promoter motifs via transcription factor ORA59. Plant Cell (2013) 1.41
Kinome profiling in pediatric brain tumors as a new approach for target discovery. Cancer Res (2009) 1.40
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res (2008) 1.36
Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: an underestimated phenomenon. Arch Intern Med (2004) 1.35
Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. Gastroenterology (2007) 1.34
Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer. Hepatology (2012) 1.33
Mechanistic view of risk factors for venous thromboembolism. Arterioscler Thromb Vasc Biol (2012) 1.33
Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia. Cancer Res (2006) 1.32
Molecular mechanism of violacein-mediated human leukemia cell death. Blood (2004) 1.27
Ethylene signaling renders the jasmonate response of Arabidopsis insensitive to future suppression by salicylic Acid. Mol Plant Microbe Interact (2010) 1.25
Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells. Carcinogenesis (2005) 1.25
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood (2009) 1.23
Hedgehog: an unusual signal transducer. Bioessays (2004) 1.22
Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells. J Biol Chem (2004) 1.22
Bone marrow stromal cell interaction reduces syndecan-1 expression and induces kinomic changes in myeloma cells. Exp Cell Res (2010) 1.21
Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways. Mol Med (2004) 1.18
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites. Cell Signal (2007) 1.16
Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2. Gastroenterology (2009) 1.16
The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. Cancer (2008) 1.16
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation. Am J Pathol (2008) 1.13
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep (2006) 1.12
Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin. J Enzyme Inhib Med Chem (2007) 1.11
Vascular endothelial growth factor in the circulation in cancer patients may not be a relevant biomarker. PLoS One (2011) 1.11
Fecal microbiota transfer may increase irritable bowel syndrome and inflammatory bowel diseases-associated bacteria. Gastroenterology (2013) 1.10
Coagulation factors VIIa and Xa inhibit apoptosis and anoikis. Oncogene (2004) 1.10
IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. Carcinogenesis (2012) 1.09
Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity. Carcinogenesis (2006) 1.08
A phospholipidomic analysis of all defined human plasma lipoproteins. Sci Rep (2011) 1.07
Worsening of Bowel Symptoms Through Diet in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis (2016) 1.06
Characterization of coagulation factor synthesis in nine human primary cell types. Sci Rep (2012) 1.06
Impact of human granulocyte and monocyte isolation procedures on functional studies. Clin Vaccine Immunol (2012) 1.06
Bowel perforation after radiotherapy in a patient receiving sorafenib. J Clin Oncol (2008) 1.05
Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus. Gastroenterology (2012) 1.05
Coagulation activation and microparticle-associated coagulant activity in cancer patients. An exploratory prospective study. Thromb Haemost (2012) 1.04
Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Blood (2010) 1.04
Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders. J Cell Mol Med (2008) 1.03
Acute stress elicited by bungee jumping suppresses human innate immunity. Mol Med (2010) 1.03
Randomized trial of the effect of the low molecular weight heparin nadroparin on survival in patients with cancer. J Clin Oncol (2011) 1.02
Epidemiology and management of chronic hepatitis E infection in solid organ transplantation: a comprehensive literature review. Rev Med Virol (2013) 1.01
Factor Xa: at the crossroads between coagulation and signaling in physiology and disease. Trends Mol Med (2008) 1.01
Evidence for a minimal eukaryotic phosphoproteome? PLoS One (2007) 1.01
Understanding palliative cancer chemotherapy: about shared decisions and shared trajectories. Health Care Anal (2009) 1.00
Interleukin-10-based therapy for inflammatory bowel disease. Expert Opin Biol Ther (2003) 1.00
Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner. Proc Natl Acad Sci U S A (2013) 1.00
VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation. J Biol Chem (2002) 0.99
Assessment of chromosomal gains as compared to DNA content changes is more useful to detect dysplasia in Barrett's esophagus brush cytology specimens. Genes Chromosomes Cancer (2008) 0.98
Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases. PLoS One (2010) 0.97
The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer. Mol Med (2008) 0.97
Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function. J Mol Med (Berl) (2003) 0.96
A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia. Gastroenterology (2005) 0.96
Kinome profiling of clinical cancer specimens. Cancer Res (2010) 0.96
In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs. J RNAi Gene Silencing (2011) 0.96
Apolipoprotein B knockdown by AAV-delivered shRNA lowers plasma cholesterol in mice. Mol Ther (2011) 0.96
Regulation of p110delta PI 3-kinase gene expression. PLoS One (2009) 0.95
Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis. Am J Pathol (2010) 0.95
Are small GTPases signal hubs in sugar-mediated induction of fructan biosynthesis? PLoS One (2009) 0.95