Published in J Biol Chem on April 27, 2004
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol (2005) 1.75
Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors. J Physiol (2006) 1.58
TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. J Physiol (2007) 1.51
GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels. Neuron (2009) 1.27
Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK. Anesthesiology (2010) 1.22
Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system. Neurosci Lett (2009) 1.01
Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation. J Biol Chem (2008) 1.00
Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels. Mol Cell Neurosci (2008) 0.98
Much more than a leak: structure and function of K₂p-channels. Pflugers Arch (2015) 0.96
Functional analysis of a migraine-associated TRESK K+ channel mutation. J Neurosci (2013) 0.90
Functional analysis of missense variants in the TRESK (KCNK18) K channel. Sci Rep (2012) 0.90
TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways. J Biol Chem (2010) 0.88
Modulation of GABAergic transmission by muscarinic receptors in the entorhinal cortex of juvenile rats. J Neurophysiol (2009) 0.88
Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification. J Biol Chem (2012) 0.87
Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy. Channels (Austin) (2010) 0.86
A Role for K2P Channels in the Operation of Somatosensory Nociceptors. Front Mol Neurosci (2012) 0.86
Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model. J Neurosci (2014) 0.85
Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK. Pflugers Arch (2014) 0.83
Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels. Br J Pharmacol (2016) 0.82
Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors. PLoS One (2014) 0.82
TRESK-like potassium channels in leukemic T cells. Pflugers Arch (2008) 0.81
Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex. Hippocampus (2010) 0.81
Genes and primary headaches: discovering new potential therapeutic targets. J Headache Pain (2013) 0.80
TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Mol Med Rep (2012) 0.79
Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons. J Neurophysiol (2014) 0.79
Single-Channel Recording of TASK-3-like K Channel and Up-Regulation of TASK-3 mRNA Expression after Spinal Cord Injury in Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol (2008) 0.77
Tubulin binds to the cytoplasmic loop of TRESK background K⁺ channel in vitro. PLoS One (2014) 0.77
Effects of analgesics and antidepressants on TREK-2 and TRESK currents. Korean J Physiol Pharmacol (2016) 0.76
Myometrial relaxation of mice via expression of two pore domain acid sensitive K(+) (TASK-2) channels. Korean J Physiol Pharmacol (2016) 0.75
Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts. Biomed Res Int (2015) 0.75
Classification of 2-pore domain potassium channels based on rectification under quasi-physiological ionic conditions. Channels (Austin) (2014) 0.75
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev (2005) 2.03
Non-alcoholic fatty liver disease across the spectrum of hypothyroidism. J Hepatol (2012) 1.94
Efficacy of computed virtual chromoendoscopy on colorectal cancer screening: a prospective, randomized, back-to-back trial of Fuji Intelligent Color Enhancement versus conventional colonoscopy to compare adenoma miss rates. Gastrointest Endosc (2010) 1.85
[Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis]. Korean J Hepatol (2008) 1.83
Visceral obesity and insulin resistance as risk factors for colorectal adenoma: a cross-sectional, case-control study. Am J Gastroenterol (2009) 1.79
TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons. Am J Physiol Cell Physiol (2006) 1.78
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol (2005) 1.75
Characterization of four types of background potassium channels in rat cerebellar granule neurons. J Physiol (2002) 1.54
Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells. J Physiol (2004) 1.46
Visceral adipose tissue area as an independent risk factor for elevated liver enzyme in nonalcoholic fatty liver disease. Medicine (Baltimore) (2015) 1.41
Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain (2009) 1.34
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain (2008) 1.33
The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans. Am J Gastroenterol (2009) 1.33
Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis (2009) 1.32
Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation. J Physiol (2008) 1.20
Sagittal abdominal diameter is a strong anthropometric measure of visceral adipose tissue in the Asian general population. Diabetes Care (2010) 1.20
Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun (2013) 1.20
Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol (2003) 1.12
A low level of serum total testosterone is independently associated with nonalcoholic fatty liver disease. BMC Gastroenterol (2012) 1.09
Properties of single two-pore domain TREK-2 channels expressed in mammalian cells. J Physiol (2007) 1.09
Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor. Am J Physiol Cell Physiol (2006) 1.08
Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family. Biochem Biophys Res Commun (2004) 1.04
Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes. Brain Res (2002) 1.01
Prospective evaluation of a new stool antigen test for the detection of Helicobacter pylori, in comparison with histology, rapid urease test, (13)C-urea breath test, and serology. J Gastroenterol Hepatol (2011) 0.97
Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up: a nationwide multicenter prospective, endoscopy-based study. J Clin Gastroenterol (2009) 0.95
Distribution of abdominal visceral and subcutaneous adipose tissue and metabolic syndrome in a Korean population. Diabetes Care (2011) 0.95
Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body. J Physiol (2014) 0.93
Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B. Dig Dis Sci (2011) 0.93
Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis. Atherosclerosis (2013) 0.92
Seroprevalence of hepatitis a and associated socioeconomic factors in young healthy korean adults. Gut Liver (2011) 0.91
Real-time monitoring of neural differentiation of human mesenchymal stem cells by electric cell-substrate impedance sensing. J Biomed Biotechnol (2011) 0.89
Prediction of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: An Enhanced Model of BARD Score. Gut Liver (2013) 0.89
Differentiating small polyp histologies using real-time screening colonoscopy with Fuji Intelligent Color Enhancement. Clin Gastroenterol Hepatol (2011) 0.89
Circulating mesenchymal stem cells microparticles in patients with cerebrovascular disease. PLoS One (2012) 0.88
General and abdominal obesity and abdominal visceral fat accumulation associated with coronary artery calcification in Korean men. Atherosclerosis (2010) 0.88
Functional expression of TREK-2 in insulin-secreting MIN6 cells. Biochem Biophys Res Commun (2004) 0.87
Association between Helicobacter pylori Seropositivity and the Coronary Artery Calcium Score in a Screening Population. Gut Liver (2011) 0.86
Nonalcoholic fatty liver disease as a risk factor of arterial stiffness measured by the cardioankle vascular index. Medicine (Baltimore) (2015) 0.86
Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease. Clin Mol Hepatol (2012) 0.86
Role of physical activity in nonalcoholic fatty liver disease in terms of visceral obesity and insulin resistance. Liver Int (2014) 0.84
Helicobacter pylori Serology Inversely Correlated With the Risk and Severity of Reflux Esophagitis in Helicobacter pylori Endemic Area: A Matched Case-Control Study of 5,616 Health Check-Up Koreans. J Neurogastroenterol Motil (2011) 0.84
Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells. Cancer Lett (2011) 0.83
Targeted gene disruption of the heat shock protein 72 gene (hsp70.1) in the donor tissue is associated with a prolonged rejection-free survival in the murine skin allograft model. Transpl Immunol (2004) 0.83
Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts. Clin Nutr (2013) 0.82
Inducible nitric oxide synthase inhibitors prolonged the survival of skin xenografts through selective down-regulation of pro-inflammatory cytokine and CC-chemokine expressions. Transpl Immunol (2003) 0.82
Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evid Based Complement Alternat Med (2013) 0.82
Association between colorectal adenoma and coronary atherosclerosis detected by CT coronary angiography in Korean men; a cross-sectional study. J Gastroenterol Hepatol (2010) 0.80
THIK-1 (K2P13.1) is a small-conductance background K(+) channel in rat trigeminal ganglion neurons. Pflugers Arch (2013) 0.80
Negative hepatitis B envelope antigen predicts intrahepatic recurrence in hepatitis B virus-related hepatocellular carcinoma after ablation therapy. J Gastroenterol Hepatol (2011) 0.80
Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species. Pflugers Arch (2012) 0.80
Xenogeneic interaction between human CD40L and porcine CD40 activates porcine endothelial cells through NF-kappaB signaling. Mol Immunol (2007) 0.80
Clinical prediction of failure of Lamivudine prophylaxis for hepatitis B virus-infected patients undergoing cytotoxic chemotherapy for malignancy. Antimicrob Agents Chemother (2012) 0.80
Noninvasive fibrosis indices predict intrahepatic distant recurrence of hepatitis B-related hepatocellular carcinoma following radiofrequency ablation. Liver Int (2013) 0.80
Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. Am J Physiol Cell Physiol (2003) 0.80
MHC expression in a human adult stem cell line and its down-regulation by hCMV US gene transfection. Int J Biochem Cell Biol (2005) 0.78
Choice of the adequate detection time for the accurate evaluation of the efficiency of siRNA-induced gene silencing. J Biotechnol (2005) 0.78
Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts. Xenotransplantation (2006) 0.78
Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. J Physiol (2003) 0.78
Visceral Obesity Predicts Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Medicine (Baltimore) (2015) 0.78
STAT6 expression and IL-13 production in association with goblet cell hyperplasia and worm expulsion of Gymnophalloides seoi from C57BL/6 mice. Korean J Parasitol (2013) 0.77
AgSbF₆-controlled diastereodivergence in alkyne hydroarylation: facile access to Z- and E-alkenyl arenes. Chem Commun (Camb) (2014) 0.77
Elevated peripheral blood monocyte fraction in nonalcoholic fatty liver disease. Tohoku J Exp Med (2011) 0.77
Noninvasive markers: a double-edged sword that stratifies nonalcoholic steatohepatitis. Clin Mol Hepatol (2013) 0.75
The Role of Spleen Stiffness in Determining the Severity and Bleeding Risk of Esophageal Varices in Cirrhotic Patients. Medicine (Baltimore) (2015) 0.75
Correction: Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis. PLoS One (2016) 0.75
Oxygen sensing with ion channels. Channels (Austin) (2014) 0.75
The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells. Arch Pharm Res (2012) 0.75
Comparison of Narrow Band Imaging and Fujinon Intelligent Color Enhancement in Predicting Small Colorectal Polyp Histology. Dig Dis Sci (2015) 0.75
Long-term Patient and Graft Survival of Kidney Transplant Recipients with Hepatitis C Virus Infection in the United States. Transplantation (2017) 0.75
The effects of reaction factors on the fabrication of nano-sized indium tin oxide powder by spray pyrolysis process. J Nanosci Nanotechnol (2012) 0.75
Hepatic fat, not visceral fat, is associated with gallbladder polyps: a study of 2643 healthy subjects. J Gastroenterol Hepatol (2015) 0.75
Structure-based virtual screening approach to the discovery of phosphoinositide 3-kinase alpha inhibitors. Bioorg Med Chem Lett (2011) 0.75
The Relationship Between Colonoscopy Procedure Order and Adenoma Detection Rates: A Prospective Study. J Clin Gastroenterol (2015) 0.75