Published in J Biol Chem on April 28, 2004
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest (2005) 1.55
Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma. Br J Cancer (2015) 1.42
Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis (2011) 1.38
Axl-dependent signalling: a clinical update. Clin Sci (Lond) (2012) 1.28
Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma. Blood (2010) 1.04
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab (2014) 1.02
Extracellular superoxide dismutase is a growth regulatory mediator of tissue injury recovery. Mol Ther (2008) 1.00
Axl as a mediator of cellular growth and survival. Oncotarget (2014) 0.99
High glucose induces human endothelial dysfunction through an Axl-dependent mechanism. Cardiovasc Diabetol (2014) 0.98
Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv Nutr (2012) 0.97
Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors. Clin Cancer Res (2015) 0.96
Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress. J Leukoc Biol (2009) 0.94
Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol (2010) 0.93
Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2008) 0.93
Prostaglandin E₂ induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. J Immunol (2012) 0.90
Mannose-binding lectin and the balance between immune protection and complication. Expert Rev Anti Infect Ther (2011) 0.89
Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents. Oncogene (2015) 0.86
Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension (2010) 0.85
Plasma concentrations predict aortic expression of growth-arrest-specific protein 6 in patients undergoing coronary artery bypass grafting. PLoS One (2013) 0.83
TAM receptor deficiency affects adult hippocampal neurogenesis. Metab Brain Dis (2014) 0.82
Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells. Oncotarget (2015) 0.78
Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL. Oncotarget (2017) 0.75
Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway. Mol Cell Biochem (2017) 0.75
Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest (2017) 0.75
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80
Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening. Arterioscler Thromb Vasc Biol (2003) 2.44
Expanding the definition and classification of hypertension. J Clin Hypertens (Greenwich) (2005) 2.35
Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase. Circ Res (2003) 2.33
Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med (2009) 2.24
Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway. Circ Res (2006) 2.24
The multifunctional GIT family of proteins. J Cell Sci (2006) 2.24
Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined. Circulation (2004) 2.21
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. Nat Cell Biol (2002) 1.94
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension (2002) 1.88
Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing. Circ Res (2007) 1.87
Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Circ Res (2006) 1.86
Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway. Arterioscler Thromb Vasc Biol (2002) 1.79
Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. J Clin Invest (2005) 1.77
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation (2006) 1.67
Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res (2003) 1.66
Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering. J Am Soc Nephrol (2005) 1.64
Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells. Circ Res (2008) 1.63
Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.61
Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem (2002) 1.57
Adiponectin inversely correlates with high sensitive C-reactive protein and triglycerides, but not with insulin sensitivity, in apparently healthy Japanese men. Endocr J (2007) 1.54
Thioredoxin: a key regulator of cardiovascular homeostasis. Circ Res (2003) 1.54
Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo. Circulation (2003) 1.53
Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circ Res (2006) 1.52
Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation (2006) 1.46
Strain-dependent differences in responses to exercise training in inbred and hybrid mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.44
Development, worsening, and improvement of diabetic microangiopathy in older people: six-year prospective study of patients under intensive diabetes control. J Am Geriatr Soc (2007) 1.43
Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome (2012) 1.43
GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor. Mol Cell Biol (2004) 1.42
Fibronectin is an important regulator of flow-induced vascular remodeling. Arterioscler Thromb Vasc Biol (2009) 1.40
Flow shear stress and atherosclerosis: a matter of site specificity. Antioxid Redox Signal (2011) 1.39
Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Circ Res (2006) 1.37
Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon. Arterioscler Thromb Vasc Biol (2007) 1.36
Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation (2008) 1.34
A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A (2005) 1.34
GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J Biol Chem (2005) 1.33
Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy. Cardiovasc Res (2002) 1.33
Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. J Biol Chem (2005) 1.31
Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res (2004) 1.29
Angiotensin II and the endothelium: diverse signals and effects. Hypertension (2005) 1.28
Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases. Methods Mol Biol (2006) 1.27
Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells. Circ Res (2003) 1.26
Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms. Antioxid Redox Signal (2011) 1.24
Thioredoxin in the cardiovascular system. J Mol Med (Berl) (2006) 1.23
GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor. J Biol Chem (2003) 1.22
The role of MAP kinases in endothelial activation. Vascul Pharmacol (2002) 1.22
Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae. J Biol Chem (2004) 1.20
Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways. Arterioscler Thromb Vasc Biol (2006) 1.20
Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism. Proc Natl Acad Sci U S A (2010) 1.19
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med (2010) 1.18
Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid Redox Signal (2010) 1.17
Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator. Arterioscler Thromb Vasc Biol (2003) 1.17
GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. Circ Res (2004) 1.16
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol (2011) 1.15
BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha. Circ Res (2005) 1.15
Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. J Mol Cell Cardiol (2004) 1.15
NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. Biochem Biophys Res Commun (2005) 1.14
Thioredoxin: a multifunctional antioxidant enzyme in kidney, heart and vessels. Curr Opin Nephrol Hypertens (2005) 1.13
Human amnion-isolated cells normalize blood glucose in streptozotocin-induced diabetic mice. Cell Transplant (2003) 1.12
Angiotensin II signaling pathways mediated by tyrosine kinases. Int J Biochem Cell Biol (2003) 1.09
G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation (2009) 1.09
Impact of impaired insulin secretion and insulin resistance on the incidence of diabetes in a Japanese cohort. Diabetologia (2013) 1.09
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood (2010) 1.07
Epidermal growth factor receptor transactivation is regulated by glucose in vascular smooth muscle cells. J Biol Chem (2003) 1.07
Flow-mediated signaling modulates endothelial cell phenotype. Endothelium (2006) 1.05
Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species. Arterioscler Thromb Vasc Biol (2011) 1.05
GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2008) 1.05
Smooth muscle apoptosis and vascular remodeling. Curr Opin Hematol (2008) 1.04
Cyclophilin A: promising new target in cardiovascular therapy. Circ J (2010) 1.04
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Circ Res (2012) 1.03
Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol (2004) 1.03
Prospective analysis of mortality, morbidity, and risk factors in elderly diabetic subjects: Nagano study. Diabetes Care (2003) 1.02
PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arterioscler Thromb Vasc Biol (2008) 1.01
Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening. Arterioscler Thromb Vasc Biol (2005) 1.01
Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res (2010) 1.00
Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. J Biol Chem (2005) 1.00
Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II. Hypertension (2002) 1.00
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Arterioscler Thromb Vasc Biol (2009) 0.99
Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circ Res (2002) 0.99
GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. Arterioscler Thromb Vasc Biol (2008) 0.98
ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation. J Biol Chem (2004) 0.97
Shear stress is differentially regulated among inbred rat strains. Circ Res (2003) 0.96
Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arterioscler Thromb Vasc Biol (2007) 0.96
Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun (2008) 0.95
Nutrient modulation of palmitoylated 24-kilodalton protein in rat pancreatic islets. Endocrinology (2003) 0.95