Published in BMC Biochem on May 05, 2004
Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways. EMBO J (2008) 1.04
Coverage of whole proteome by structural genomics observed through protein homology modeling database. J Struct Funct Genomics (2006) 0.82
Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast. BMC Evol Biol (2015) 0.77
From Genome to Structure and Back Again: A Family Portrait of the Transcarbamylases. Int J Mol Sci (2015) 0.76
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
A general method applicable to the search for similarities in the amino acid sequence of two proteins. J Mol Biol (1970) 155.96
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis (1997) 57.27
Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms. J Mol Biol (1988) 1.96
Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides. J Biol Chem (1977) 1.87
Superproduction and rapid purification of Escherichia coli aspartate transcarbamylase and its catalytic subunit under extreme derepression of the pyrimidine pathway. J Biol Chem (1985) 1.65
In the presence of CTP, UTP becomes an allosteric inhibitor of aspartate transcarbamoylase. Proc Natl Acad Sci U S A (1989) 1.56
The carB gene of Escherichia coli: a duplicated gene coding for the large subunit of carbamoyl-phosphate synthetase. Proc Natl Acad Sci U S A (1983) 1.44
Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of the six biosynthetic enzymes. Biochemistry (1973) 1.43
Evidence for an activated form of carbon dioxide in the reaction catalyzed by Escherichia coli carbamyl phosphate synthetase. Biochemistry (1965) 1.33
Yeast carbamyl phosphate synthetase. Structure of the yeast gene and homology to Escherichia coli carbamyl phosphate synthetase. J Biol Chem (1983) 1.25
Conversion of carbamoyl phosphate to hydroxyurea. An assay for carbamoylphosphate synthetase. Anal Biochem (1971) 1.19
A study of the aspartate transcarbamylase activity of yeast. Arch Biochem Biophys (1967) 1.17
Aggregation states and catalytic properties of the multienzyme complex catalyzing the initial steps of pyrimidine biosynthesis in rat liver. Biochemistry (1975) 1.11
The rudimentary gene of Drosophila melanogaster encodes four enzymic functions. J Mol Biol (1987) 1.10
Mechanism and regulation of the glutamine-dependent carbamyl phosphate synthetase of Escherichia coli. Adv Enzymol Relat Areas Mol Biol (1989) 1.07
The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 1.05
Molecular characterization of a Dictyostelium discoideum gene encoding a multifunctional enzyme of the pyrimidine pathway. Eur J Biochem (1989) 1.02
The aspartate transcarbamylase and carbamoyl phosphate synthetase of yeast: a multi-functional enzyme complex. Biochem Biophys Res Commun (1969) 0.99
Mammalian dihydroorotase: nucleotide sequence, peptide sequences, and evolution of the dihydroorotase domain of the multifunctional protein CAD. Proc Natl Acad Sci U S A (1990) 0.96
The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. Eur J Biochem (2003) 0.92
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase. J Biol Chem (1999) 0.91
Escherichia coli carbamoyl-phosphate synthetase: domains of glutaminase and synthetase subunit interaction. Proc Natl Acad Sci U S A (1989) 0.91
The primary structure of the aspartate transcarbamylase region of the URA2 gene product in Saccharomyces cerevisiae. Features involved in activity and nuclear localization. J Biol Chem (1989) 0.90
Domain structure of the large subunit of Escherichia coli carbamoyl phosphate synthetase. Location of the binding site for the allosteric inhibitor UMP in the COOH-terminal domain. Biochemistry (1991) 0.88
Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways. J Mol Biol (1999) 0.88
In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways. Arch Biochem Biophys (1994) 0.87
In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. I. Catalytic and regulatory properties of aspartate transcarbamylase. Arch Biochem Biophys (1983) 0.86
Quantifying the allosteric properties of Escherichia coli carbamyl phosphate synthetase: determination of thermodynamic linked-function parameters in an ordered kinetic mechanism. Biochemistry (1992) 0.85
Identification of the regulatory domain of the mammalian multifunctional protein CAD by the construction of an Escherichia coli hamster hybrid carbamyl-phosphate synthetase. J Biol Chem (1994) 0.84
Function of the major synthetase subdomains of carbamyl-phosphate synthetase. J Biol Chem (1996) 0.83
The gene coding for carbamoyl-phosphate synthetase I was formed by fusion of an ancestral glutaminase gene and a synthetase gene. Proc Natl Acad Sci U S A (1985) 0.83
Genetic analysis of yeast strains lacking negative feedback control: a one-step method for positive selection and cloning of carbamoylphosphate synthetase-aspartate transcarbamoylase mutants unable to respond to UTP. Mol Gen Genet (1993) 0.82
Allosteric regulation and substrate channeling in multifunctional pyrimidine biosynthetic complexes: analysis of isolated domains and yeast-mammalian chimeric proteins. J Mol Biol (1998) 0.82
Proteolytically induced changes in the molecular form of the carbamyl phosphate synthetase-uracil-aspartate transcarbamylase complex coded for by the URA2 locus in Saccharomyces cerevisiae. J Bacteriol (1981) 0.81
Half of Saccharomyces cerevisiae carbamoyl phosphate synthetase produces and channels carbamoyl phosphate to the fused aspartate transcarbamoylase domain. J Biol Chem (1999) 0.80
Kinetics and reaction mechanism of the carbamylphosphate synthetase of a multienzyme aggregate from yeast. Can J Biochem (1975) 0.78
The carbamoyl phosphate synthetase-aspartate transcarbamoylase complex of Saccharomyces cerevisiae: molecular and cellular aspects. Biochem Soc Trans (1993) 0.78
Homology and mutagenesis studies of hamster dihydroorotase. Adv Exp Med Biol (1994) 0.77
Structural modeling and electrostatic properties of aspartate transcarbamylase from Saccharomyces cerevisiae. Proteins (1994) 0.77
Pressure-induced dissociation of carbamoyl-phosphate synthetase domains. The catalytically active form is dimeric. J Biol Chem (1998) 0.77
Global health 2035: a world converging within a generation. Lancet (2013) 16.85
Genome evolution in yeasts. Nature (2004) 10.50
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Does home based medication review keep older people out of hospital? The HOMER randomised controlled trial. BMJ (2005) 3.35
Neighborhood effects on health: correcting bias from neighborhood effects on participation. Epidemiology (2011) 2.59
The challenge of preventing environmentally related disease in young children: community-based research in New York City. Environ Health Perspect (2002) 2.48
Nocturnal blood pressure reduction: effect on retrobulbar hemodynamics in glaucoma. Graefes Arch Clin Exp Ophthalmol (2002) 2.14
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets. FEBS Lett (2007) 2.02
Neighbourhoods in eco-epidemiologic research: delimiting personal exposure areas. A response to Riva, Gauvin, Apparicio and Brodeur. Soc Sci Med (2009) 1.98
Comparative genomics of protoploid Saccharomycetaceae. Genome Res (2009) 1.96
GFP expression in muscle cells impairs actin-myosin interactions: implications for cell therapy. Nat Methods (2006) 1.83
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest (2009) 1.83
Individual/neighborhood social factors and blood pressure in the RECORD Cohort Study: which risk factors explain the associations? Hypertension (2010) 1.74
Impact of physician asthma care education on patient outcomes. Pediatrics (2006) 1.70
Restrictive cardiomyopathy with atrioventricular conduction block resulting from a desmin mutation. Int J Cardiol (2006) 1.62
Génolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes. Nucleic Acids Res (2008) 1.56
An individualized intervention to improve asthma management among urban Latino and African-American families. J Asthma (2002) 1.54
Respiratory insufficiency in desminopathy patients caused by introduction of proline residues in desmin c-terminal alpha-helical segment. Muscle Nerve (2003) 1.50
Vancouver simplified grading system with computed tomographic angiography for blunt aortic injury. J Thorac Cardiovasc Surg (2011) 1.43
Goodpasture's disease in the absence of circulating anti-glomerular basement membrane antibodies as detected by standard techniques. Am J Kidney Dis (2002) 1.42
ER quality control can lead to retrograde transport from the ER lumen to the cytosol and the nucleoplasm in plants. Plant J (2003) 1.40
Why I didn't get a paycheck last month. Fam Pract Manag (2012) 1.39
Identity and emergency intervention: how social group membership and inclusiveness of group boundaries shape helping behavior. Pers Soc Psychol Bull (2005) 1.36
An official American Thoracic Society systematic review: the association between health insurance status and access, care delivery, and outcomes for patients who are critically ill. Am J Respir Crit Care Med (2010) 1.32
Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol (2006) 1.30
Peritoneal dialysis in elderly patients: report from the French Peritoneal Dialysis Registry (RDPLF). Nephrol Dial Transplant (2009) 1.29
Genolevures complete genomes provide data and tools for comparative genomics of hemiascomycetous yeasts. Nucleic Acids Res (2006) 1.28
Health systems performance assessment in the Bulletin. Bull World Health Organ (2009) 1.25
Determinants of cockroach and mouse exposure and associations with asthma in families and elderly individuals living in New York City public housing. Ann Allergy Asthma Immunol (2006) 1.24
Conspicuous involvement of desmin tail mutations in diverse cardiac and skeletal myopathies. Hum Mutat (2007) 1.24
Neighborhood-level confounding in epidemiologic studies: unavoidable challenges, uncertain solutions. Epidemiology (2010) 1.24
Asthma education: the adolescent experience. Patient Educ Couns (2004) 1.23
Designing health financing policy towards universal coverage. Bull World Health Organ (2007) 1.23
Génolevures: comparative genomics and molecular evolution of hemiascomycetous yeasts. Nucleic Acids Res (2004) 1.22
Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part I: General Ultrasonography. Crit Care Med (2015) 1.21
Is assisted peritoneal dialysis associated with technique survival when competing events are considered? Clin J Am Soc Nephrol (2012) 1.21
Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. PLoS Med (2012) 1.19
Progressive skeletal myopathy, a phenotypic variant of desmin myopathy associated with desmin mutations. Neuromuscul Disord (2003) 1.17
Assessing the relationship between language proficiency and asthma morbidity among inner-city asthmatics. Med Care (2009) 1.15
"Hey, mom, thanks!": use of focus groups in the development of place-specific materials for a community environmental action campaign. Environ Health Perspect (2002) 1.15
Variable pathogenic potentials of mutations located in the desmin alpha-helical domain. Hum Mutat (2006) 1.14
On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria. Hum Mol Genet (2003) 1.13
Use of written treatment plans for asthma by specialist physicians. Pediatr Pulmonol (2007) 1.12
Pichia sorbitophila, an Interspecies Yeast Hybrid, Reveals Early Steps of Genome Resolution After Polyploidization. G3 (Bethesda) (2012) 1.12
Strategies to improve adherence to recommended chloroquine treatment regimes: a quasi-experiment in the context of integrated primary health care delivery in Ghana. Soc Sci Med (2002) 1.12
School-based asthma programs. J Allergy Clin Immunol (2009) 1.11
Intermediate filament diseases: desminopathy. Adv Exp Med Biol (2008) 1.11
Peritoneal dialysis in polycystic kidney disease patients. Report from the French peritoneal dialysis registry (RDPLF). Nephrol Dial Transplant (2010) 1.10
Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton. Exp Cell Res (2006) 1.10
Recovery of a function involving gene duplication by retroposition in Saccharomyces cerevisiae. Genome Res (2004) 1.09
Pesticide sales in low-income, minority neighborhoods. J Community Health (2004) 1.08
Feasibility and impact of a school-based intervention for families of urban adolescents with asthma: results from a randomized pilot trial. Fam Process (2008) 1.08
Pathogenic effects of a novel heterozygous R350P desmin mutation on the assembly of desmin intermediate filaments in vivo and in vitro. Hum Mol Genet (2005) 1.06
Effects of a school-based intervention for urban adolescents with asthma. A controlled trial. Am J Respir Crit Care Med (2010) 1.05
Impact of deferred treatment of blunt diaphragmatic rupture: a 15-year experience in six trauma centers in Quebec. J Trauma (2002) 1.03
A series of West European patients with severe cardiac and skeletal myopathy associated with a de novo R406W mutation in desmin. J Neurol (2004) 1.03
Asthma knowledge and asthma management behavior in urban elementary school teachers. J Asthma (2010) 1.03
Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension. Am J Pathol (2007) 1.03
Quality of reporting on patient and public involvement within surgical research: a systematic review. Ann Surg (2015) 1.02
Evaluation of three fall-risk assessment tools in an acute care setting. J Adv Nurs (2007) 1.02
Myopathy-associated alphaB-crystallin mutants: abnormal phosphorylation, intracellular location, and interactions with other small heat shock proteins. J Biol Chem (2007) 1.02
Hsp27-2D-gel electrophoresis is a diagnostic tool to differentiate primary desminopathies from myofibrillar myopathies. FEBS Lett (2005) 1.00
Residue R120 is essential for the quaternary structure and functional integrity of human alphaB-crystallin. Biochemistry (2007) 1.00
Feedback as a strategy to change behaviour: the devil is in the details. J Eval Clin Pract (2011) 1.00
Abnormal small heat shock protein interactions involving neuropathy-associated HSP22 (HSPB8) mutants. FASEB J (2006) 1.00
Desmin myopathy with severe cardiomyopathy in a Uruguayan family due to a codon deletion in a new location within the desmin 1A rod domain. Neuromuscul Disord (2010) 0.98
Using school staff to establish a preventive network of care to improve elementary school students' control of asthma. J Sch Health (2006) 0.98
Validating an asthma case detection instrument in a Head Start sample. J Sch Health (2006) 0.97
In-frame deletion in the seventh immunoglobulin-like repeat of filamin C in a family with myofibrillar myopathy. Eur J Hum Genet (2008) 0.97
Design, synthesis and activity of bisubstrate, transition-state analogues and competitive inhibitors of aspartate transcarbamylase. Eur J Med Chem (2004) 0.96
Group cognitive behavioural interventions for low back pain in primary care: extended follow-up of the Back Skills Training Trial (ISRCTN54717854). Pain (2012) 0.96
The impact of participation in performing arts on adolescent health and behaviour: a systematic review of the literature. J Health Psychol (2008) 0.96
Findings of a randomized controlled trial using limited transthoracic echocardiogram (LTTE) as a hemodynamic monitoring tool in the trauma bay. J Trauma Acute Care Surg (2014) 0.95
Nanoparticle-enhanced sensitivity of a nanogap-interdigitated electrode array impedimetric biosensor. Langmuir (2011) 0.95
Desmin-related myopathy: clinical, electrophysiological, radiological, neuropathological and genetic studies. J Neurol Sci (2004) 0.95
Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells. J Biol Chem (2010) 0.94
Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins. Exp Cell Res (2011) 0.94
Effect of drug sample removal on prescribing in a family practice clinic. Ann Fam Med (2010) 0.94
Community health workers as drivers of a successful community-based disease management initiative. Am J Public Health (2012) 0.94
Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease. Exp Cell Res (2007) 0.94
Characterization of trisulfide modification in antibodies. Anal Biochem (2010) 0.93
Self-reported moisture or mildew in the homes of Head Start children with asthma is associated with greater asthma morbidity. J Urban Health (2006) 0.93
Commentary: Socioeconomic status, health behavior, and mortality: old question plus modern methods equals new insights? Epidemiology (2014) 0.93
Small deletions disturb desmin architecture leading to breakdown of muscle cells and development of skeletal or cardioskeletal myopathy. Hum Genet (2003) 0.93
Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability. Microbiology (2002) 0.93
Rhombohedral prussian white as cathode for rechargeable sodium-ion batteries. J Am Chem Soc (2015) 0.92
Expansion and contraction of the DUP240 multigene family in Saccharomyces cerevisiae populations. Genetics (2004) 0.91
Differential involvement of sarcomeric proteins in myofibrillar myopathies: a morphological and immunohistochemical study. Acta Neuropathol (2009) 0.91
Surface-immobilized peptide aptamers as probe molecules for protein detection. Anal Chem (2008) 0.91
Commentary: Weighing up the dead and missing: reflections on inverse-probability weighting and principal stratification to address truncation by death. Epidemiology (2012) 0.91
Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid. Pediatrics (2007) 0.90
Effectiveness of an integrated pest management intervention in controlling cockroaches, mice, and allergens in New York City public housing. Environ Health Perspect (2009) 0.90