Published in Electrophoresis on December 01, 1997
SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res (2003) 25.86
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
ExPASy: The proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res (2003) 17.39
The PROSITE database, its status in 2002. Nucleic Acids Res (2002) 14.71
The SWISS-MODEL Repository and associated resources. Nucleic Acids Res (2008) 11.61
Geometric nomenclature and classification of RNA base pairs. RNA (2001) 9.08
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Res (2014) 8.86
ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res (2003) 6.86
The FoldX web server: an online force field. Nucleic Acids Res (2005) 6.30
Presenting your structures: the CCP4mg molecular-graphics software. Acta Crystallogr D Biol Crystallogr (2011) 6.27
Protein structure homology modeling using SWISS-MODEL workspace. Nat Protoc (2009) 5.42
The non-Watson-Crick base pairs and their associated isostericity matrices. Nucleic Acids Res (2002) 5.35
TOUCHSTONE II: a new approach to ab initio protein structure prediction. Biophys J (2003) 4.62
Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. Genetics (2004) 4.51
The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol (2001) 4.39
The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models. Nucleic Acids Res (2004) 4.30
KING (Kinemage, Next Generation): a versatile interactive molecular and scientific visualization program. Protein Sci (2009) 4.21
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc Natl Acad Sci U S A (2002) 4.12
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S A (2003) 4.06
Comparative genomics and evolution of proteins involved in RNA metabolism. Nucleic Acids Res (2002) 4.00
Sequence and structural analysis of BTB domain proteins. Genome Biol (2005) 3.88
Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. EMBO J (2002) 3.88
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet (2009) 3.80
SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. Nucleic Acids Res (2000) 3.56
Semidwarf (sd-1), "green revolution" rice, contains a defective gibberellin 20-oxidase gene. Proc Natl Acad Sci U S A (2002) 3.51
Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Res (2005) 3.36
Adeno-associated viruses undergo substantial evolution in primates during natural infections. Proc Natl Acad Sci U S A (2003) 3.31
Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J (2009) 3.19
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood (2011) 3.16
Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol (2003) 3.02
The SWISS-MODEL Repository: new features and functionalities. Nucleic Acids Res (2006) 3.00
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription. Proc Natl Acad Sci U S A (2003) 2.92
Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A (2002) 2.91
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Proc Natl Acad Sci U S A (2001) 2.90
Replication-defective vector based on a chimpanzee adenovirus. J Virol (2001) 2.86
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol (2010) 2.83
Polyester synthases: natural catalysts for plastics. Biochem J (2003) 2.83
A newly discovered protein export machine in malaria parasites. Nature (2009) 2.79
New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome Biol (2003) 2.77
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Nucleic Acids Res (2002) 2.76
Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet (2005) 2.75
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J (2002) 2.72
Light-activated DNA binding in a designed allosteric protein. Proc Natl Acad Sci U S A (2008) 2.67
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J (2000) 2.67
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A (2011) 2.67
Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein. J Virol (2002) 2.66
Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes. J Virol (2004) 2.64
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature (2010) 2.62
The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications. BMC Bioinformatics (2005) 2.60
Biophysical characterization and vector-specific antagonist activity of domain III of the tick-borne flavivirus envelope protein. J Virol (2001) 2.59
Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J (2004) 2.58
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol (2005) 2.55
Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes Dev (2000) 2.55
Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. EMBO J (2002) 2.53
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev (2007) 2.50
Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members. Nucleic Acids Res (2005) 2.49
Structural insight into the biogenesis of β-barrel membrane proteins. Nature (2013) 2.46
Matt: local flexibility aids protein multiple structure alignment. PLoS Comput Biol (2008) 2.41
Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels. Genome Biol (2004) 2.39
On the mechanism of MgATP-dependent gating of CFTR Cl- channels. J Gen Physiol (2003) 2.39
Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature (2008) 2.39
Yeast surface display for protein engineering and characterization. Curr Opin Struct Biol (2007) 2.38
A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J (2003) 2.37
Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily. Plant Physiol (2004) 2.36
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol (2007) 2.29
Spotted leaf11, a negative regulator of plant cell death and defense, encodes a U-box/armadillo repeat protein endowed with E3 ubiquitin ligase activity. Plant Cell (2004) 2.28
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem Rev (2008) 2.27
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J (2006) 2.27
Crystal structure of sensory rhodopsin II at 2.4 angstroms: insights into color tuning and transducer interaction. Science (2001) 2.25
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev (2003) 2.23
Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C). PLoS One (2008) 2.23
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. EMBO J (1998) 2.20
The variability of sesquiterpenes emitted from two Zea mays cultivars is controlled by allelic variation of two terpene synthase genes encoding stereoselective multiple product enzymes. Plant Cell (2004) 2.19
Pervasive cryptic epistasis in molecular evolution. PLoS Genet (2010) 2.19
Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. Genome Res (2001) 2.19
Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Am J Hum Genet (2005) 2.17
Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev (2011) 2.14
The prepower stroke conformation of myosin V. J Cell Biol (2002) 2.12
An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol (2007) 2.11
Structural and phylogenetic analysis of adenovirus hexons by use of high-resolution x-ray crystallographic, molecular modeling, and sequence-based methods. J Virol (2003) 2.10
Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor. Proc Natl Acad Sci U S A (2003) 2.09
Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. Nucleic Acids Res (2002) 2.08
Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. J Clin Invest (2009) 2.08
Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. EMBO J (2005) 2.08
Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein. J Virol (2002) 2.06
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther (2004) 2.05
Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. Proc Natl Acad Sci U S A (2005) 2.05
Molecular basis of a progressive juvenile-onset hereditary cataract. Proc Natl Acad Sci U S A (2000) 2.04
SCOR: Structural Classification of RNA, version 2.0. Nucleic Acids Res (2004) 2.02
Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Proc Natl Acad Sci U S A (2003) 2.02
Predicted structure and phyletic distribution of the RNA-binding protein Hfq. Nucleic Acids Res (2002) 2.01
Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature (2010) 2.01
CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes. J Bacteriol (2004) 2.00
Designed to be stable: crystal structure of a consensus ankyrin repeat protein. Proc Natl Acad Sci U S A (2003) 1.98
ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J (2002) 1.98
Protein modelling for all. Trends Biochem Sci (1999) 4.41
Clinical spectrum of X-linked hyper-IgM syndrome. J Pediatr (1997) 3.63
Protein structure computing in the genomic era. Res Microbiol (2000) 2.38
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. J Biol Chem (1997) 1.58
Selectivity and antagonism of chemokine receptors. J Leukoc Biol (1996) 1.49
Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma. J Biol Chem (1991) 1.44
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. Genomics (1997) 1.39
Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. Curr Top Microbiol Immunol (1995) 1.22
New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling. Genome Res (1998) 1.21
Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin. Nature (1989) 1.14
Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative. Immunity (1995) 1.07
Characterization of the non-functional Fas ligand of gld mice. Int Immunol (1995) 1.06
The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. J Leukoc Biol (1997) 1.04
A new function for an old enzyme: the role of DNase I in apoptosis. Curr Top Microbiol Immunol (1995) 1.01
Genomic impact of cigarette smoke, with application to three smoking-related diseases. Crit Rev Toxicol (2012) 1.00
CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome. Immunol Today (1996) 1.00
Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death. Eur J Cell Biol (1993) 0.96
Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding. J Biol Chem (1994) 0.92
Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1). Am J Hum Genet (1997) 0.92
Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Eur J Biochem (1997) 0.91
Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death). Eur J Cell Biol (1994) 0.90
Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation. J Biol Chem (1995) 0.89
Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei. Biochem Biophys Res Commun (1992) 0.88
Amino acid sequence of the alpha subunit and computer modelling of the alpha and beta subunits of echicetin from the venom of Echis carinatus (saw-scaled viper). Biochem J (1997) 0.87
Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. Mol Immunol (1991) 0.85
alpha 1 but not alpha 2 or alpha 3 isoforms of Na,K-ATPase are efficiently phosphorylated in a novel protein kinase C motif. Biochemistry (1996) 0.84
Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein. Mol Immunol (1993) 0.83
Covalent homodimers of murine secretory component induced by epitope substitution unravel the capacity of the polymeric Ig receptor to dimerize noncovalently in the absence of IgA ligand. J Biol Chem (1999) 0.81
Antibody-independent activation of C1. I. Differences in the mechanism of C1 activation by nonimmune activators and by immune complexes: C1r-independent activation of C1s by cardiolipin vesicles. J Immunol (1987) 0.81
Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement. J Immunol (1987) 0.80
Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding. Mol Cell Endocrinol (1995) 0.79
Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I. J Biol Chem (1994) 0.79
Structure and bioactivity of recombinant human CTAP-III and NAP-2. J Protein Chem (1997) 0.79
Tandem mass spectrometry protein identification on a PC grid. Stud Health Technol Inform (2007) 0.78
Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown. Eur J Cell Biol (1996) 0.78
Hydrophobic C-terminal amino acids in the beta-subunit are involved in assembly with the alpha-subunit of Na,K-ATPase. Biochemistry (1993) 0.78
Protein tertiary structure modeling. Curr Protoc Protein Sci (2001) 0.78
Spatial orientation of the alpha and betac receptor chain binding sites on monomeric human interleukin-5 constructs. J Biol Chem (1997) 0.77
Human CD40 ligand: molecular cloning, cellular distribution and regulation of IgE synthesis. Res Immunol (1995) 0.77
The molecular basis of selectivity between CC and CXC chemokines: the possibility of chemokine antagonists as anti-inflammatory agents. Ann N Y Acad Sci (1996) 0.75
The carboxy-terminal region of human interleukin-5 is essential for maintenance of tertiary structure but not for dimerization. J Protein Chem (1996) 0.75
Identification of novel chemokines from expressed sequence tag databases. Methods Mol Biol (2000) 0.75
MDB: a database system utilizing automatic construction of modules and STAR-derived universal language. Bioinformatics (2001) 0.75
Defining the regions of human interleukin-5 important in receptor binding and cellular activation. Ann N Y Acad Sci (1996) 0.75