1
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A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
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Proc Natl Acad Sci U S A
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2004
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3.48
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2
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Increased lipogenesis in cancer cells: new players, novel targets.
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Curr Opin Clin Nutr Metab Care
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2006
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3.09
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3
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RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells.
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Cancer Res
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2005
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2.01
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4
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RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
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Cancer Res
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2003
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1.97
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5
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Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells.
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Cancer Res
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2007
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1.81
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6
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Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue.
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Endocrinology
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2009
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1.66
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7
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Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.
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Int J Cancer
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2002
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1.65
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8
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De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.
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Cancer Res
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2010
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1.59
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9
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Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.
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Cancer Res
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2005
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1.57
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10
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Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
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J Biol Chem
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2004
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1.55
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11
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Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal.
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Proc Natl Acad Sci U S A
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2011
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1.53
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12
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Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.
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Biochem Biophys Res Commun
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2003
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1.52
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13
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The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor.
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Endocrinology
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2005
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1.36
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14
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The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice.
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Mol Endocrinol
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2005
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1.34
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15
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Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha.
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FASEB J
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2008
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1.31
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16
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Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.
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Cancer Res
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2002
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1.31
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17
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Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses.
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J Neurosci
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2009
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1.29
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18
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Androgens, lipogenesis and prostate cancer.
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J Steroid Biochem Mol Biol
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2004
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1.28
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19
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Role of androgens in fetal testis development and dysgenesis.
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Endocrinology
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2007
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1.27
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20
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High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.
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J Pathol
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2005
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1.22
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21
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Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells.
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Biochem J
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2002
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1.18
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22
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Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice.
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Mol Cell Endocrinol
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2011
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1.18
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23
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Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model.
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J Bone Miner Res
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2006
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1.17
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24
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Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor.
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J Biol Chem
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2004
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1.16
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25
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Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.
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Mol Cancer Ther
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2006
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1.14
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26
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Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis.
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Mol Endocrinol
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2012
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1.14
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27
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Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia.
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Endocrinology
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2010
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1.09
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28
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Androgen activation of the sterol regulatory element-binding protein pathway: Current insights.
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Mol Endocrinol
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2006
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1.08
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29
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Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells.
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Int J Cancer
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2003
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1.07
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30
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Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.
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Proc Natl Acad Sci U S A
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2007
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1.06
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31
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The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.
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Genes Dev
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2007
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1.06
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32
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Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes.
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Mol Endocrinol
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2009
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1.06
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33
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Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.
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PLoS One
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2010
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1.05
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34
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Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells.
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Proc Natl Acad Sci U S A
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2014
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1.04
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35
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Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor.
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Endocrinology
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2005
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1.03
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36
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Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice.
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Endocrinology
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2006
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1.01
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37
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Androgen receptor-dependent and independent atheroprotection by testosterone in male mice.
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Endocrinology
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2010
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0.99
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38
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Implications of a polyglutamine tract in the function of the human androgen receptor.
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Biochem Biophys Res Commun
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2003
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0.98
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39
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Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice.
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J Bone Miner Res
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2010
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0.98
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40
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Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.
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J Biol Chem
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2007
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0.95
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41
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Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo.
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Mol Cell Endocrinol
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2003
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0.94
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42
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Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice.
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J Androl
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2009
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0.94
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43
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Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.
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Cancer Res
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2010
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0.87
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44
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Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells.
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Biol Reprod
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2011
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0.86
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45
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Transfection with steroid-responsive reporter constructs shows glucocorticoid rather than androgen responsiveness in cultured Sertoli cells.
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J Steroid Biochem Mol Biol
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2006
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0.83
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46
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Coactivation of an endogenous progesterone receptor by TIF2 in COS-7 cells.
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Biochem Biophys Res Commun
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2002
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0.82
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47
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Androgen regulation of lipogenesis.
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Adv Exp Med Biol
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2002
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0.81
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48
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Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice.
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Reprod Biol Endocrinol
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2009
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0.81
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49
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Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach.
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Mol Endocrinol
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2014
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0.80
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50
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A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene.
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FASEB J
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2012
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0.78
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51
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Physical activity in the androgen receptor knockout mouse: evidence for reversal of androgen deficiency on cancellous bone.
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Biochem Biophys Res Commun
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2008
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0.78
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52
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The development of an inducible androgen receptor knockout model in mouse to study the postmeiotic effects of androgens on germ cell development.
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Spermatogenesis
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2011
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0.78
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53
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Both retinoids and androgens are required to maintain or promote functional differentiation in reaggregation cultures of human prostate epithelial cells.
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Prostate
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2002
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0.77
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54
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Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.
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Biol Reprod
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2009
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0.77
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55
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Tissue-selective knockouts of steroid receptors: a novel paradigm in the study of steroid action.
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Methods Mol Biol
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2009
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0.75
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