PubRank

Guido Verhoeven

Author PubWeight™ 65.81‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A 2004 3.48
2 Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care 2006 3.09
3 RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 2005 2.01
4 RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 2003 1.97
5 Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res 2007 1.81
6 Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology 2009 1.66
7 Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer 2002 1.65
8 De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 2010 1.59
9 Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res 2005 1.57
10 Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem 2004 1.55
11 Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proc Natl Acad Sci U S A 2011 1.53
12 Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun 2003 1.52
13 The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology 2005 1.36
14 The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Mol Endocrinol 2005 1.34
15 Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha. FASEB J 2008 1.31
16 Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res 2002 1.31
17 Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses. J Neurosci 2009 1.29
18 Androgens, lipogenesis and prostate cancer. J Steroid Biochem Mol Biol 2004 1.28
19 Role of androgens in fetal testis development and dysgenesis. Endocrinology 2007 1.27
20 High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. J Pathol 2005 1.22
21 Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells. Biochem J 2002 1.18
22 Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice. Mol Cell Endocrinol 2011 1.18
23 Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model. J Bone Miner Res 2006 1.17
24 Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor. J Biol Chem 2004 1.16
25 Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. Mol Cancer Ther 2006 1.14
26 Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis. Mol Endocrinol 2012 1.14
27 Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology 2010 1.09
28 Androgen activation of the sterol regulatory element-binding protein pathway: Current insights. Mol Endocrinol 2006 1.08
29 Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int J Cancer 2003 1.07
30 Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A 2007 1.06
31 The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. Genes Dev 2007 1.06
32 Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes. Mol Endocrinol 2009 1.06
33 Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PLoS One 2010 1.05
34 Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells. Proc Natl Acad Sci U S A 2014 1.04
35 Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor. Endocrinology 2005 1.03
36 Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. Endocrinology 2006 1.01
37 Androgen receptor-dependent and independent atheroprotection by testosterone in male mice. Endocrinology 2010 0.99
38 Implications of a polyglutamine tract in the function of the human androgen receptor. Biochem Biophys Res Commun 2003 0.98
39 Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice. J Bone Miner Res 2010 0.98
40 Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. J Biol Chem 2007 0.95
41 Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Mol Cell Endocrinol 2003 0.94
42 Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. J Androl 2009 0.94
43 Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development. Cancer Res 2010 0.87
44 Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod 2011 0.86
45 Transfection with steroid-responsive reporter constructs shows glucocorticoid rather than androgen responsiveness in cultured Sertoli cells. J Steroid Biochem Mol Biol 2006 0.83
46 Coactivation of an endogenous progesterone receptor by TIF2 in COS-7 cells. Biochem Biophys Res Commun 2002 0.82
47 Androgen regulation of lipogenesis. Adv Exp Med Biol 2002 0.81
48 Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice. Reprod Biol Endocrinol 2009 0.81
49 Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach. Mol Endocrinol 2014 0.80
50 A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene. FASEB J 2012 0.78
51 Physical activity in the androgen receptor knockout mouse: evidence for reversal of androgen deficiency on cancellous bone. Biochem Biophys Res Commun 2008 0.78
52 The development of an inducible androgen receptor knockout model in mouse to study the postmeiotic effects of androgens on germ cell development. Spermatogenesis 2011 0.78
53 Both retinoids and androgens are required to maintain or promote functional differentiation in reaggregation cultures of human prostate epithelial cells. Prostate 2002 0.77
54 Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment. Biol Reprod 2009 0.77
55 Tissue-selective knockouts of steroid receptors: a novel paradigm in the study of steroid action. Methods Mol Biol 2009 0.75