Published in J Biol Chem on May 06, 2004
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res (2008) 6.33
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J (2011) 2.97
Androgen modulation of coregulator expression in prostate cancer cells. Mol Endocrinol (2009) 1.14
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res (2013) 1.12
Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis (2014) 1.03
Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc Natl Acad Sci U S A (2005) 0.98
Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. J Biol Chem (2010) 0.91
Targeting androgen receptor action for prostate cancer treatment: does the post-receptor level provide novel opportunities? Int J Biol Sci (2014) 0.84
Estrogen receptor alpha regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence. Mol Cell Endocrinol (2007) 0.83
Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr (2007) 0.82
Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol (2012) 0.81
Effect of Daxx on cholesterol accumulation in hepatic cells. World J Gastroenterol (2008) 0.79
Basic helix loop helix (bHLH) transcription factor 3 (TCF3, E2A) is regulated by androgens in prostate cancer cells. Am J Cancer Res (2015) 0.78
ORTI: An Open-Access Repository of Transcriptional Interactions for Interrogating Mammalian Gene Expression Data. PLoS One (2016) 0.75
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism. Int J Mol Sci (2015) 0.75
A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer. Elife (2017) 0.75
Fracture risk and zoledronic acid therapy in men with osteoporosis. N Engl J Med (2012) 3.51
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A (2004) 3.48
Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care (2006) 3.09
RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res (2005) 2.01
Structural basis of androgen receptor binding to selective androgen response elements. Proc Natl Acad Sci U S A (2004) 1.97
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res (2003) 1.97
Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res (2007) 1.81
Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology (2009) 1.66
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer (2002) 1.65
De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res (2010) 1.59
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res (2005) 1.57
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem (2004) 1.55
Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proc Natl Acad Sci U S A (2011) 1.53
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun (2003) 1.52
ATP-citrate lyase: a key player in cancer metabolism. Cancer Res (2012) 1.48
Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res (2013) 1.46
Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Mol Genet Metab (2003) 1.37
The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology (2005) 1.36
The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor. Cancer Res (2007) 1.35
The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Mol Endocrinol (2005) 1.34
Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha. FASEB J (2008) 1.31
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res (2002) 1.31
Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab (2004) 1.31
Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses. J Neurosci (2009) 1.29
Androgens, lipogenesis and prostate cancer. J Steroid Biochem Mol Biol (2004) 1.28
Role of androgens in fetal testis development and dysgenesis. Endocrinology (2007) 1.27
Lipoprotein lipase links dietary fat to solid tumor cell proliferation. Mol Cancer Ther (2011) 1.27
Sex steroid actions in male bone. Endocr Rev (2014) 1.26
Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity. Cancer Res (2008) 1.26
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. J Pathol (2005) 1.22
Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice. Mol Cell Endocrinol (2011) 1.18
Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells. Biochem J (2002) 1.18
The rules of DNA recognition by the androgen receptor. Mol Endocrinol (2010) 1.17
Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model. J Bone Miner Res (2006) 1.17
Androgens and spermatogenesis: lessons from transgenic mouse models. Philos Trans R Soc Lond B Biol Sci (2010) 1.16
Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis. Mol Endocrinol (2012) 1.14
Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. Mol Cancer Ther (2006) 1.14
Interplay between two hormone-independent activation domains in the androgen receptor. Cancer Res (2006) 1.10
Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology (2010) 1.09
Androgen activation of the sterol regulatory element-binding protein pathway: Current insights. Mol Endocrinol (2006) 1.08
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int J Cancer (2003) 1.07
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A (2007) 1.06
The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. Genes Dev (2007) 1.06
Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes. Mol Endocrinol (2009) 1.06
Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PLoS One (2010) 1.05
ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms. Mol Cancer Ther (2012) 1.04
Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells. Proc Natl Acad Sci U S A (2014) 1.04
Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor. Mol Cell Biol (2012) 1.03
Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor. Endocrinology (2005) 1.03
Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. Endocrinology (2006) 1.01
Looking at nuclear receptors from a new angle. Mol Cell Endocrinol (2013) 1.01
Inhibition of cathepsin K for treatment of osteoporosis. Curr Osteoporos Rep (2012) 1.00
Androgen receptor-dependent and independent atheroprotection by testosterone in male mice. Endocrinology (2010) 0.99
Implications of a polyglutamine tract in the function of the human androgen receptor. Biochem Biophys Res Commun (2003) 0.98
The hinge region in androgen receptor control. Mol Cell Endocrinol (2012) 0.98
Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice. J Bone Miner Res (2010) 0.98
Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European Male Aging Study (EMAS). J Clin Endocrinol Metab (2013) 0.98
Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes. J Bone Miner Res (2012) 0.98
Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. J Biol Chem (2007) 0.95
Dual function of an amino-terminal amphipatic helix in androgen receptor-mediated transactivation through specific and nonspecific response elements. J Biol Chem (2002) 0.95
Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Mol Cell Endocrinol (2003) 0.94
Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. J Androl (2009) 0.94
A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels. Cell Mol Life Sci (2010) 0.93
Characterization of the two coactivator-interacting surfaces of the androgen receptor and their relative role in transcriptional control. J Biol Chem (2002) 0.92