Published in J Biol Chem on May 15, 2004
Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase. ACS Chem Biol (2009) 2.40
Mammalian long-chain acyl-CoA synthetases. Exp Biol Med (Maywood) (2008) 2.28
Structure and function of enzymes involved in the biosynthesis of phenylpropanoids. Plant Physiol Biochem (2007) 2.01
Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase. Biochemistry (2008) 1.68
Acyl-CoA synthesis, lipid metabolism and lipotoxicity. Biochim Biophys Acta (2009) 1.58
Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry (2007) 1.49
Versatility of acyl-acyl carrier protein synthetases. Chem Biol (2014) 1.46
Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. Nat Chem Biol (2009) 1.39
Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis. Biochemistry (2008) 1.31
The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol (2012) 1.31
Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorg Med Chem Lett (2008) 1.19
Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains. BMC Biochem (2010) 1.08
The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase. Biochemistry (2009) 1.07
Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains. BMC Mol Biol (2006) 1.06
Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism. J Inherit Metab Dis (2011) 1.06
Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis. Biochemistry (2010) 1.04
Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A. J Biol Chem (2010) 1.03
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. J Am Chem Soc (2007) 1.02
Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis. ACS Chem Biol (2011) 1.00
Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chem Soc Rev (2008) 0.98
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes. J Am Chem Soc (2010) 0.95
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem (2011) 0.94
Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis. PLoS One (2009) 0.93
Xanthomonas campestris RpfB is a fatty Acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase. Mol Microbiol (2014) 0.93
Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol. J Biol Chem (2011) 0.92
Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range. Biochemistry (2007) 0.91
Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. Biochim Biophys Acta (2010) 0.88
Metabolic and tissue-specific regulation of acyl-CoA metabolism. PLoS One (2015) 0.88
Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis. J Biol Chem (2009) 0.87
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement. BMC Bioinformatics (2010) 0.87
The 2.1 A crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substrates. Proteins (2009) 0.87
Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme. J Biol Chem (2013) 0.86
Defining a structural and kinetic rationale for paralogous copies of phenylacetate-CoA ligases from the cystic fibrosis pathogen Burkholderia cenocepacia J2315. J Biol Chem (2011) 0.84
Structural and functional studies of fatty acyl adenylate ligases from E. coli and L. pneumophila. J Mol Biol (2010) 0.84
Mechanistic studies of the long chain acyl-CoA synthetase Faa1p from Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 0.83
Structure of the D-alanylgriseoluteic acid biosynthetic protein EhpF, an atypical member of the ANL superfamily of adenylating enzymes. Acta Crystallogr D Biol Crystallogr (2010) 0.79
Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria. J Biol Chem (2016) 0.79
Mutagenesis of rat acyl-CoA synthetase 4 indicates amino acids that contribute to fatty acid binding. Biochim Biophys Acta (2006) 0.79
Outlook: membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases. Front Physiol (2012) 0.79
Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles. BMC Bioinformatics (2010) 0.78
Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder. Biochim Biophys Acta (2013) 0.78
Physiological role of Acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa. Eukaryot Cell (2013) 0.78
Molecular modeling studies of Fatty acyl-CoA synthetase (FadD13) from Mycobacterium tuberculosis--a potential target for the development of antitubercular drugs. J Mol Model (2010) 0.78
Bioinformatic Analysis of Leishmania donovani Long-Chain Fatty Acid-CoA Ligase as a Novel Drug Target. Mol Biol Int (2011) 0.78
Mass spectrometry analysis and transcriptome sequencing reveal glowing squid crystal proteins are in the same superfamily as firefly luciferase. Sci Rep (2016) 0.77
Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury. Bioorg Med Chem Lett (2014) 0.77
Carnitine transport and fatty acid oxidation. Biochim Biophys Acta (2016) 0.76
Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase. J Biol Chem (2015) 0.76
Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids. PeerJ (2015) 0.76
Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes. Bioorg Med Chem Lett (2016) 0.75
Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry. ChemCatChem (2017) 0.75
Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit. Int J Mol Sci (2017) 0.75
A novel aromatic carboxylic acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue. PLoS One (2013) 0.75
A peroxisomal long-chain acyl-CoA synthetase from Glycine max involved in lipid degradation. PLoS One (2014) 0.75
O-GlcNAcylation: a bridge between glucose and cell differentiation. J Cell Mol Med (2016) 0.75
Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study. PLoS One (2016) 0.75
Alanylated lipoteichoic acid primer in Bacillus subtilis. F1000Res (2016) 0.75
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature (2002) 6.74
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell (2006) 5.70
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell (2002) 5.64
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell (2003) 5.06
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol (2006) 4.89
Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell (2007) 4.73
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev (2007) 4.35
Protein production and purification. Nat Methods (2008) 3.97
Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription. Cell (2004) 3.39
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol (2006) 3.23
ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding. EMBO J (2003) 3.14
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A (2013) 3.10
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. Nat Genet (2008) 2.98
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat Struct Biol (2003) 2.71
Structural basis for substrate selection by t7 RNA polymerase. Cell (2004) 2.62
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Mol Cell (2007) 2.62
Structural basis for transcription regulation by alarmone ppGpp. Cell (2004) 2.60
Structure of a T7 RNA polymerase elongation complex at 2.9 A resolution. Nature (2002) 2.57
Structural basis for recruitment of human flap endonuclease 1 to PCNA. EMBO J (2004) 2.57
Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol (2010) 2.51
Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Cell (2011) 2.46
An unnatural hydrophobic base pair system: site-specific incorporation of nucleotide analogs into DNA and RNA. Nat Methods (2006) 2.46
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A (2010) 2.36
Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases. Biochem Biophys Res Commun (2008) 2.29
Alternative tertiary structure of tRNA for recognition by a posttranscriptional modification enzyme. Cell (2003) 2.29
Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain. Protein Sci (2006) 2.29
KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell (2007) 2.20
Micro-crystallography comes of age. Curr Opin Struct Biol (2012) 2.17
Preparation of Escherichia coli cell extract for highly productive cell-free protein expression. J Struct Funct Genomics (2004) 2.14
Multistep engineering of pyrrolysyl-tRNA synthetase to genetically encode N(epsilon)-(o-azidobenzyloxycarbonyl) lysine for site-specific protein modification. Chem Biol (2008) 2.13
Reconstitution reveals the functional core of mammalian eIF3. EMBO J (2007) 2.06
A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction. J Virol (2009) 2.03
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein. Nature (2010) 2.01
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep (2003) 2.01
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. Biochem J (2003) 2.00
The CENP-S complex is essential for the stable assembly of outer kinetochore structure. J Cell Biol (2009) 1.99
Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form. Mol Cell (2002) 1.98
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome. Structure (2007) 1.97
Inference of S-system models of genetic networks using a cooperative coevolutionary algorithm. Bioinformatics (2004) 1.96
Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins. J Cell Biol (2011) 1.94
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly. Mol Cell (2005) 1.93
Genetic variants in C5 and poor response to eculizumab. N Engl J Med (2014) 1.91
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation. Nat Struct Mol Biol (2005) 1.87
RIKEN structural genomics beamlines at the SPring-8; high throughput protein crystallography with automated beamline operation. J Struct Funct Genomics (2006) 1.85
CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. Cell (2012) 1.85
CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly. Mol Biol Cell (2007) 1.85
Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition. Nat Struct Mol Biol (2005) 1.82
Beamline Scheduling Software: administration software for automatic operation of the RIKEN structural genomics beamlines at SPring-8. J Synchrotron Radiat (2005) 1.78
Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression. J Natl Cancer Inst (2002) 1.78
An enzyme with a deep trefoil knot for the active-site architecture. Acta Crystallogr D Biol Crystallogr (2002) 1.72
Codon reassignment in the Escherichia coli genetic code. Nucleic Acids Res (2010) 1.68
Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid. Nat Methods (2005) 1.67
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet (2012) 1.67
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature (2007) 1.66
Crystal structure of elongation factor P from Thermus thermophilus HB8. Proc Natl Acad Sci U S A (2004) 1.65
Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem Biol (2011) 1.65
Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography. Structure (2009) 1.64
Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells. Nucleic Acids Res (2002) 1.64
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G. EMBO J (2009) 1.63
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Mol Cell Biol (2010) 1.63
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat Struct Mol Biol (2010) 1.62
Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Cell (2002) 1.59
Site-specific incorporation of a photo-crosslinking component into RNA by T7 transcription mediated by unnatural base pairs. Chem Biol (2004) 1.59
Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol Cell (2004) 1.57
An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules. Nucleic Acids Res (2008) 1.56
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem (2006) 1.56
Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase. Structure (2006) 1.56
Expression and purification of recombinant human histones. Methods (2004) 1.54
Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J Biol Chem (2006) 1.54
Structural basis of replication origin recognition by the DnaA protein. Nucleic Acids Res (2003) 1.54
Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. Structure (2004) 1.53
Drosophila U6 promoter-driven short hairpin RNAs effectively induce RNA interference in Schneider 2 cells. Biochem Biophys Res Commun (2005) 1.53
Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA. Proc Natl Acad Sci U S A (2007) 1.52
Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol (2003) 1.52
Transcription profile of Thermus thermophilus CRISPR systems after phage infection. J Mol Biol (2009) 1.50
Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression. RNA (2009) 1.50
Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences. Genome Res (2010) 1.50
CENP-T provides a structural platform for outer kinetochore assembly. EMBO J (2013) 1.49
Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region. J Biol Chem (2008) 1.48
Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology. Nat Methods (2007) 1.48
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol (2006) 1.47
Vertebrate kinetochore protein architecture: protein copy number. J Cell Biol (2010) 1.47
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol (2003) 1.47