Published in Antimicrob Agents Chemother on June 01, 2004
The TetR family of transcriptional repressors. Microbiol Mol Biol Rev (2005) 6.02
Clinical and economic impact of common multidrug-resistant gram-negative bacilli. Antimicrob Agents Chemother (2007) 3.44
Efflux-mediated drug resistance in bacteria: an update. Drugs (2009) 3.18
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev (2015) 1.81
Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. Antimicrob Agents Chemother (2010) 1.58
Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. Antimicrob Agents Chemother (2007) 1.57
Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes. Antimicrob Agents Chemother (2005) 1.31
Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline. Antimicrob Agents Chemother (2005) 1.20
Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline. Antimicrob Agents Chemother (2009) 1.12
Validation and reproducibility assessment of tigecycline MIC determinations by Etest. J Clin Microbiol (2007) 1.09
Occurrence of tetracycline resistance genes among Escherichia coli isolates from the phase 3 clinical trials for tigecycline. Antimicrob Agents Chemother (2007) 0.97
Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa. Front Microbiol (2015) 0.94
A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM. J Bacteriol (2007) 0.93
Identification, cloning, and functional characterization of EmrD-3, a putative multidrug efflux pump of the major facilitator superfamily from Vibrio cholerae O395. Arch Microbiol (2009) 0.88
Superinfection during treatment of nosocomial infections with tigecycline. Eur J Clin Microbiol Infect Dis (2010) 0.85
The ins and outs of RND efflux pumps in Escherichia coli. Front Microbiol (2015) 0.84
Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily. Int J Bacteriol (2015) 0.83
Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance. Antimicrob Agents Chemother (2015) 0.78
Tigecycline non-susceptibility occurs exclusively in fluoroquinolone-resistant Escherichia coli clinical isolates, including the major multidrug-resistant lineages O25b:H4-ST131-H30R and O1-ST648. Antimicrob Agents Chemother (2016) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol (1979) 43.48
The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA. Nucleic Acids Res (1985) 12.11
Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev (2001) 9.14
Proton-dependent multidrug efflux systems. Microbiol Rev (1996) 8.81
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli. Proc Natl Acad Sci U S A (1980) 8.43
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol (1995) 8.41
Crystal structure of bacterial multidrug efflux transporter AcrB. Nature (2002) 6.47
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J Bacteriol (1993) 6.24
Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol (2001) 4.69
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother (1999) 4.44
NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother (1998) 4.11
Mechanisms of solvent tolerance in gram-negative bacteria. Annu Rev Microbiol (2002) 3.50
AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis. Antimicrob Agents Chemother (2003) 1.98
Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother (2003) 1.97
Transposition of the oxacillin-hydrolyzing penicillinase gene. J Bacteriol (1981) 1.82
Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon, Tn10. The role of the conserved dipeptide, Ser65-Asp66, in tetracycline transport. J Biol Chem (1990) 1.78
Energetics of tetracycline efflux system encoded by Tn10 in Escherichia coli. FEBS Lett (1985) 1.57
New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors. Drug Resist Updat (2002) 1.40
Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy. J Antimicrob Chemother (2003) 1.33
Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines. Microb Drug Resist (2000) 1.30
Glycylcyclines: third-generation tetracycline antibiotics. Curr Opin Pharmacol (2001) 1.28
Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10. Histidine 257 plays an essential role in H+ translocation. J Biol Chem (1991) 1.25
The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions. Proc Natl Acad Sci U S A (2003) 1.17
Membrane topology of a multidrug efflux transporter, AcrB, in Escherichia coli. J Biochem (2002) 1.10
A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter. Antimicrob Agents Chemother (1995) 1.05
The tetracycline efflux protein encoded by the tet(K) gene from Staphylococcus aureus is a metal-tetracycline/H+ antiporter. FEBS Lett (1995) 1.04
Orientation of the carboxyl terminus of the transposon Tn10-encoded tetracycline resistance protein in Escherichia coli. FEBS Lett (1990) 1.02
Aspartic acid-66 is the only essential negatively charged residue in the putative hydrophilic loop region of the metal-tetracycline/H+ antiporter encoded by transposon Tn10 of Escherichia coli. Biochemistry (1992) 0.97
Novel antibacterial agents for the treatment of serious Gram-positive infections. Expert Opin Investig Drugs (2003) 0.91
Novelties in the field of anti-infectives in 1998. Clin Infect Dis (1999) 0.85
A novel compound, 1,1-dimethyl-5(1-hydroxypropyl)-4,6,7-trimethylindan, is an effective inhibitor of the tet(K) gene-encoded metal-tetracycline/H+ antiporter of Staphylococcus aureus. FEBS Lett (1997) 0.82
Expression in Escherichia coli of a TetK determinant from Staphylococcus aureus. Biol Pharm Bull (1994) 0.78
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84
Crystal structure of bacterial multidrug efflux transporter AcrB. Nature (2002) 6.47
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature (2006) 5.35
Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica. Proc Natl Acad Sci U S A (2005) 2.40
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science (2008) 2.35
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J Bacteriol (2002) 2.34
Indole induces the expression of multidrug exporter genes in Escherichia coli. Mol Microbiol (2005) 2.28
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature (2011) 1.89
EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli. J Bacteriol (2002) 1.82
Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking. Biochemistry (2005) 1.58
Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J Bacteriol (2003) 1.54
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. J Lipid Res (2005) 1.54
Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos (2011) 1.49
AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals. J Biol Chem (2008) 1.45
Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. J Bacteriol (2005) 1.44
Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. J Bacteriol (2006) 1.34
Structural basis for the inhibition of bacterial multidrug exporters. Nature (2013) 1.31
The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem (2010) 1.29
Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams. Antimicrob Agents Chemother (2003) 1.28
Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. PLoS One (2012) 1.28
Multidrug-exporting secondary transporters. Curr Opin Struct Biol (2003) 1.27
Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella. Biochim Biophys Acta (2009) 1.26
Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli. J Bacteriol (2003) 1.26
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J Antimicrob Chemother (2003) 1.24
Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. J Biol Chem (2009) 1.24
Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium. J Bacteriol (2007) 1.23
Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport. J Biol Chem (2003) 1.23
Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. J Bacteriol (2004) 1.23
Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157:H7. Microbiology (2009) 1.19
Anaerobic nitrogen-fixing consortia consisting of clostridia isolated from gramineous plants. Appl Environ Microbiol (2004) 1.17
Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation. Autophagy (2010) 1.13
Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli. FEBS Lett (2003) 1.12
Membrane topology of a multidrug efflux transporter, AcrB, in Escherichia coli. J Biochem (2002) 1.10
Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes. Drug Metab Dispos (2011) 1.10
Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels. PLoS One (2011) 1.07
Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos (2006) 1.07
TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium. J Antimicrob Chemother (2010) 0.99
Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Appl Environ Microbiol (2006) 0.98
Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat. Microbiology (2010) 0.96
Mechanisms of drug/H+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach. Curr Opin Chem Biol (2003) 0.95
Identification of a spermidine excretion protein complex (MdtJI) in Escherichia coli. J Bacteriol (2007) 0.94
Indole enhances acid resistance in Escherichia coli. Microb Pathog (2010) 0.92
The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes. J Infect Chemother (2008) 0.92
Alternative explanation for indole-induced antibiotic tolerance in Salmonella. Proc Natl Acad Sci U S A (2013) 0.89
Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli. J Antimicrob Chemother (2010) 0.89
Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos (2005) 0.89
Impact of the RNA chaperone Hfq on multidrug resistance in Escherichia coli. J Antimicrob Chemother (2010) 0.88
Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide. Drug Metab Dispos (2008) 0.88
Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One (2013) 0.88
The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic respiration in Escherichia coli. J Biol Chem (2011) 0.87
A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors. Front Microbiol (2012) 0.87
A concise total synthesis of (+)-neopeltolide. Angew Chem Int Ed Engl (2010) 0.87
AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli. J Bacteriol (2008) 0.87
Expression of the nifH gene of a Herbaspirillum endophyte in wild rice species: daily rhythm during the light-dark cycle. Appl Environ Microbiol (2005) 0.87
CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes. J Antibiot (Tokyo) (2008) 0.86
ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. Mol Cell Biol (2005) 0.86
Effect of NlpE overproduction on multidrug resistance in Escherichia coli. Antimicrob Agents Chemother (2010) 0.85
Autoimmune disorder phenotypes in Hvcn1-deficient mice. Biochem J (2013) 0.85
β-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket. J Biol Chem (2014) 0.85
Role of xenobiotic transporters in bacterial drug resistance and virulence. IUBMB Life (2008) 0.85
A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array. Lab Chip (2012) 0.85
The crystal structure of multidrug-resistance regulator RamR with multiple drugs. Nat Commun (2013) 0.85
Design of a large-scale femtoliter droplet array for single-cell analysis of drug-tolerant and drug-resistant bacteria. Front Microbiol (2013) 0.84
Roles of Salmonella multidrug efflux pumps in tigecycline resistance. J Antimicrob Chemother (2010) 0.83
N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli. J Bacteriol (2006) 0.83
Total synthesis and biological evaluation of (+)-neopeltolide and its analogues. Chemistry (2009) 0.82
Effects of natural mutations in the ramRA locus on invasiveness of epidemic fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates. J Infect Dis (2012) 0.82
Impact of hfq on the intrinsic drug resistance of salmonella enterica serovar typhimurium. Front Microbiol (2012) 0.81
Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium. J Antimicrob Chemother (2013) 0.80
Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit. Biochem Biophys Res Commun (2007) 0.80
Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis. Biochem Biophys Res Commun (2003) 0.80
AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium. J Antibiot (Tokyo) (2011) 0.80
Covalently linking the Escherichia coli global anaerobic regulator FNR in tandem allows it to function as an oxygen stable dimer. Biochem Biophys Res Commun (2012) 0.80