Published in Biochemistry on June 01, 2004
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes. Proc Natl Acad Sci U S A (2006) 1.64
The pyruvate dehydrogenase complexes: structure-based function and regulation. J Biol Chem (2014) 1.31
Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps. FEBS J (2009) 1.28
Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations. Bioorg Chem (2005) 1.21
Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis. J Am Chem Soc (2007) 1.12
Electronic and nuclear magnetic resonance spectroscopic features of the 1',4'-iminopyrimidine tautomeric form of thiamin diphosphate, a novel intermediate on enzymes requiring this coenzyme. Biochemistry (2006) 1.08
Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex. Bioorg Chem (2006) 1.08
Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex. Proc Natl Acad Sci U S A (2008) 1.01
Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases. Bioorg Chem (2006) 0.92
Solid-state NMR and density functional theory studies of ionization states of thiamin. J Phys Chem B (2010) 0.90
Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor. Biochemistry (2009) 0.89
Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester. Biochemistry (2008) 0.89
Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate . Biochemistry (2010) 0.89
Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase). J Mol Biol (2008) 0.88
Nuclear magnetic resonance evidence for the role of the flexible regions of the E1 component of the pyruvate dehydrogenase complex from gram-negative bacteria. J Biol Chem (2009) 0.86
Bifunctionality of the thiamin diphosphate cofactor: assignment of tautomeric/ionization states of the 4'-aminopyrimidine ring when various intermediates occupy the active sites during the catalysis of yeast pyruvate decarboxylase. J Am Chem Soc (2012) 0.86
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem (2013) 0.85
Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex. J Biol Chem (2014) 0.83
Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multienzyme complex. Structure (2008) 0.82
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. Biochemistry (2009) 0.81
Multiple roles of mobile active center loops in the E1 component of the Escherichia coli pyruvate dehydrogenase complex - Linkage of protein dynamics to catalysis. J Mol Catal B Enzym (2009) 0.81
Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate. J Biol Chem (2014) 0.80
Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies. Biochemistry (2014) 0.79
Catalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples. ACS Catal (2013) 0.78
Accuracy of ICD-9-CM codes for identifying cardiovascular and stroke risk factors. Med Care (2005) 7.73
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors. Clin Infect Dis (2007) 3.21
Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J (2006) 3.05
A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol (2012) 2.54
Clinical and economic outcomes of the electronic intensive care unit: results from two community hospitals. Crit Care Med (2010) 2.22
Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation. Blood (2010) 2.19
The effect of adverse housing and neighborhood conditions on the development of diabetes mellitus among middle-aged African Americans. Am J Epidemiol (2007) 2.17
Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood (2010) 2.15
Long-term followup after laparoscopic radical nephrectomy. J Urol (2002) 2.07
Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther (2008) 1.90
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res (2006) 1.78
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77
The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. J Urol (2006) 1.73
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat Neurosci (2006) 1.70
Are racial disparities in pancreatic cancer explained by smoking and overweight/obesity? Cancer Epidemiol Biomarkers Prev (2009) 1.70
Hand-assisted laparoscopic vs. laparoscopic colorectal surgery: a multicenter, prospective, randomized trial. Dis Colon Rectum (2008) 1.67
Optimal vaccination strategies for 2009 pandemic H1N1 and seasonal influenza vaccines in humans. Vaccine (2010) 1.65
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes. Proc Natl Acad Sci U S A (2006) 1.64
Combination therapy with desmopressin and an anticholinergic medication for nonresponders to desmopressin for monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial. Pediatrics (2008) 1.64
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Enuresis is a common and persistent problem among children and young adults with sickle cell anemia. Urology (2008) 1.53
Long-term results of an RTOG Phase II trial (00-19) of external-beam radiation therapy combined with permanent source brachytherapy for intermediate-risk clinically localized adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys (2012) 1.52
Effect of hyperthyroidism on the hypercoagulable state and thromboembolic events in patients with atrial fibrillation. Cardiology (2014) 1.50
FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs. Mol Cell (2009) 1.49
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chem Biol (2010) 1.48
The efficacy of oral midazolam for decreasing anxiety in children undergoing voiding cystourethrogram: a randomized, double-blind, placebo controlled study. J Urol (2011) 1.48
NMR analysis of covalent intermediates in thiamin diphosphate enzymes. Biochemistry (2003) 1.48
An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene (2005) 1.47
Matched pair analysis of shock wave lithotripsy effectiveness for comparison of lithotriptors. J Urol (2003) 1.47
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem (2006) 1.43
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer (2010) 1.43
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet (2011) 1.42
Socioeconomic, family, and pediatric practice factors that affect level of asthma control. Pediatrics (2009) 1.41
Effects of breast cancer surgery and surgical side effects on body image over time. Breast Cancer Res Treat (2010) 1.41
Prostate-specific antigen cutoff of 2.6 ng/mL for prostate cancer screening is associated with favorable pathologic tumor features. Urology (2002) 1.41
X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP). Arch Oral Biol (2003) 1.40
Preliminary toxicity analysis of 3-dimensional conformal radiation therapy versus intensity modulated radiation therapy on the high-dose arm of the Radiation Therapy Oncology Group 0126 prostate cancer trial. Int J Radiat Oncol Biol Phys (2013) 1.40
Asymmetric somatic stem cells division plays a critical role in cell senescence. Med Hypotheses (2006) 1.38
MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. Cancer Lett (2013) 1.38
Positional accuracy and geographic bias of four methods of geocoding in epidemiologic research. Ann Epidemiol (2007) 1.37
Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states. Biochemistry (2007) 1.37
Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta. Biochemistry (2004) 1.36
Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation. J Mol Biol (2008) 1.35
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation. Proc Natl Acad Sci U S A (2012) 1.35
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A (2008) 1.33
Trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland china from 1979 to 2012. Int J Endocrinol (2013) 1.32
A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation. Cell (2006) 1.31
Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation (2009) 1.30
Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role. J Am Chem Soc (2003) 1.29
In vitro susceptibilities of yeast species to fluconazole and voriconazole as determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) study. J Clin Microbiol (2012) 1.28
Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps. FEBS J (2009) 1.28
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am J Physiol Renal Physiol (2006) 1.27
Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol (2004) 1.27
Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China. J Virol (2009) 1.27
Smoking relapse during the first year after treatment for early-stage non-small-cell lung cancer. Cancer Epidemiol Biomarkers Prev (2006) 1.26
Laparoscopic pyeloplasty for secondary ureteropelvic junction obstruction. J Urol (2003) 1.26
Novel structures and superconductivity of silane under pressure. Phys Rev Lett (2009) 1.25
Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: a retrospective analysis. J Int Med Res (2013) 1.24
Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients. Chin J Cancer Res (2013) 1.23
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab (2011) 1.21
Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol Pharmacol (2002) 1.20
The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Biochemistry (2007) 1.20
Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19
Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity. J Biol Chem (2008) 1.18
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev (2011) 1.18
Prostate-specific antigen density predicts adverse pathology and increased risk of biochemical failure. Urology (2007) 1.18
Responses of soil CO2 fluxes to short-term experimental warming in alpine steppe ecosystem, Northern Tibet. PLoS One (2013) 1.17
Small molecule tools for functional interrogation of protein tyrosine phosphatases. FEBS J (2012) 1.17
How does the radiographic size of a renal mass compare with the pathologic size? Urology (2006) 1.17
Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice. Am J Pathol (2008) 1.16
Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain (2013) 1.16
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. J Lipid Res (2009) 1.16
Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes. J Immunother (2009) 1.16
Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells. J Biol Chem (2006) 1.16
Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome. Biol Open (2014) 1.16
RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends. PLoS Genet (2009) 1.15
Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood (2008) 1.15
Pathological features of renal neoplasms classified by size and symptomatology. J Urol (2006) 1.15
Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping. Structure (2008) 1.13
Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells. J Biol Chem (2005) 1.13
Effect of the ecological water conveyance project on environment in the Lower Tarim River, Xinjiang, China. Environ Monit Assess (2008) 1.13
Alteration in irrigant flow and deflection of flexible ureteroscopes with nitinol baskets. J Endourol (2006) 1.12
Glutamate 636 of the Escherichia coli pyruvate dehydrogenase-E1 participates in active center communication and behaves as an engineered acetolactate synthase with unusual stereoselectivity. J Biol Chem (2005) 1.12
100 Tbit/s free-space data link enabled by three-dimensional multiplexing of orbital angular momentum, polarization, and wavelength. Opt Lett (2014) 1.12
Evaluation of different multidimensional LC-MS/MS pipelines for isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of potato tubers in response to cold storage. J Proteome Res (2011) 1.12
Use and accuracy of diagnostic imaging by hospital type in pediatric appendicitis. Pediatrics (2012) 1.12