Published in J Med Chem on June 03, 2004
Effect of rilmakalim on detrusor contraction in the presence and absence of urothelium. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.78
Characterization of a novel ATP-sensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters. Br J Pharmacol (2007) 0.75
Cyclization of substitued 2-(2-fluorophenylazo)azines to azino[1,2-c]benzo[d][1,2,4]triazinium derivatives. Beilstein J Org Chem (2013) 0.75
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol (2010) 5.84
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 4.74
Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Natl Acad Sci U S A (2012) 3.42
Directional water collection on wetted spider silk. Nature (2010) 3.06
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol (2007) 2.65
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60
European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD. BMC Psychiatry (2010) 2.53
Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells (2009) 2.48
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res (2010) 2.27
Contribution of hematopoietic stem cells to skeletal muscle. Nat Med (2003) 2.18
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther (2006) 2.06
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell (2012) 1.99
Allosteric modulation of nicotinic acetylcholine receptors. Biochem Pharmacol (2007) 1.98
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol Pharmacol (2007) 1.98
Targeting TRP channels for pain relief. Eur J Pharmacol (2013) 1.90
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol (2012) 1.83
Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol (2005) 1.73
Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. Am J Hum Genet (2005) 1.73
Assessment of genotype imputation methods. BMC Proc (2009) 1.68
Asperger (1906-1980) and Kanner (1894-1981), the two pioneers of autism. J Autism Dev Disord (2007) 1.66
Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Res (2008) 1.61
A multi-structural and multi-functional integrated fog collection system in cactus. Nat Commun (2012) 1.60
The overlap between alexithymia and Asperger's syndrome. J Autism Dev Disord (2006) 1.59
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states. Pain (2006) 1.55
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther (2007) 1.53
Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology (2007) 1.53
Did Michelangelo (1475-1564) have high-functioning autism? J Med Biogr (2004) 1.51
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain (2005) 1.46
Attention-deficit/hyperactivity disorder and Asperger's syndrome? J Am Acad Child Adolesc Psychiatry (2005) 1.45
Misdiagnosis of Asperger syndrome as anankastic personality disorder. Autism (2002) 1.43
Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci (2008) 1.42
Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia (2007) 1.41
Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Mol Cancer Ther (2009) 1.40
Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem Cells (2006) 1.39
Autism symptoms in Attention-Deficit/Hyperactivity Disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. J Autism Dev Disord (2008) 1.38
A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci U S A (2002) 1.38
Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration. Dev Biol (2008) 1.37
Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Cell Res (2010) 1.37
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J Med Chem (2006) 1.36
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain (2011) 1.34
Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain (2009) 1.34
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J Pharmacol Exp Ther (2005) 1.33
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther (2004) 1.33
Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clin Cancer Res (2011) 1.32
Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J Neurosci (2007) 1.32
Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem (2008) 1.30
Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame. Cell Res (2009) 1.29
Near-infrared fluorescence goggle system with complementary metal-oxide-semiconductor imaging sensor and see-through display. J Biomed Opt (2013) 1.27
Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res (2008) 1.24
Plasma amino acid levels in children with autism and their families. J Autism Dev Disord (2003) 1.24
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes. J Med Chem (2004) 1.24
Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators. Br J Pharmacol (2002) 1.23
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener. J Med Chem (2006) 1.23
The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev (2014) 1.23
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain (2010) 1.22
Stability of quantum dots in live cells. Nat Chem (2011) 1.22
Symptom domains in autism and related conditions: evidence for familiality. Am J Med Genet (2002) 1.21
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. J Neurosci (2010) 1.20
Solution-liquid-solid growth of semiconductor nanowires. Inorg Chem (2006) 1.18
European adolescent substance use: the roles of family structure, function and gender. Addiction (2002) 1.17
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol (2003) 1.17
Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood (2010) 1.14
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem (2008) 1.14
Sequence and structure signatures of cancer mutation hotspots in protein kinases. PLoS One (2009) 1.14
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes (2010) 1.14
Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res (2012) 1.13
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation. Cancer Res (2010) 1.13
PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis. J Immunol (2006) 1.13
Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation. Eur J Pharmacol (2003) 1.12
Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases. Autoimmunity (2006) 1.12
A practical influenza neutralization assay to simultaneously quantify hemagglutinin and neuraminidase-inhibiting antibody responses. Vaccine (2009) 1.11
Comparison of open and laparoscopic preperitoneal repair of groin hernia. Surg Endosc (2013) 1.10
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands. Bioorg Med Chem Lett (2010) 1.10
Self-Alert Training: volitional modulation of autonomic arousal improves sustained attention. Neuropsychologia (2007) 1.10
Concise construction of novel bridged bicyclic lactams by sequenced Ugi/RCM/Heck reactions. Org Lett (2007) 1.10
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. J Med Chem (2008) 1.10