| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Solid phase heterocyclic chemistry.
|
Chem Rev
|
2002
|
1.03
|
|
2
|
Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs).
|
Bioorg Med Chem Lett
|
2002
|
0.84
|
|
3
|
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions.
|
J Med Chem
|
2004
|
0.84
|
|
4
|
CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity.
|
Mol Cancer Ther
|
2012
|
0.81
|
|
5
|
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.
|
J Med Chem
|
2004
|
0.78
|
|
6
|
Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors.
|
Bioorg Med Chem Lett
|
2011
|
0.78
|
|
7
|
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.
|
J Med Chem
|
2012
|
0.75
|
|
8
|
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
|
J Med Chem
|
2012
|
0.75
|
|
9
|
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
|
J Med Chem
|
2002
|
0.75
|