Warfarin dosing and cytochrome P450 2C9 polymorphisms.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMID 15175798)

Published in Thromb Haemost on June 01, 2004


Hylton V Joffe1, Ruliang Xu, F Bradley Johnson, Janina Longtine, Nils Kucher, Samuel Z Goldhaber

Author Affiliations

1: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Associated clinical trials:

Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information | NCT00401414

Articles citing this

Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 4.82

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood (2008) 4.02

The largest prospective warfarin-treated cohort supports genetic forecasting. Blood (2008) 2.79

Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther (2007) 2.54

Evaluation of cytochrome P450 2C9 activity in normal, healthy, adult Western Indian population by both phenotyping and genotyping. Indian J Pharmacol (2016) 1.40

Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis. PLoS One (2012) 1.24

Applications of CYP450 testing in the clinical setting. Mol Diagn Ther (2013) 1.08

The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies -CYP2C9 and warfarin as an example. Br J Clin Pharmacol (2007) 0.88

The Creating an Optimal Warfarin Nomogram (CROWN) Study. Thromb Haemost (2011) 0.82

Influence of regular physical activity on warfarin dose and risk of hemorrhagic complications. Pharmacotherapy (2014) 0.78

An acenocoumarol dose algorithm based on a South-Eastern European population. Eur J Clin Pharmacol (2013) 0.76

Warfarin dose requirement in Turkish patients: the influences of patient characteristics and polymorphisms in CYP2C9, VKORC1 and factor VII. Hippokratia (2015) 0.76

Exposure to non-therapeutic INR in a high risk cardiovascular patient: potential hazard reduction with genotype-guided warfarin (Coumadin) dosing. P R Health Sci J (2010) 0.75

Medical Comorbidity and Complications. Child Adolesc Psychiatr Clin N Am (2016) 0.75

Articles by these authors

Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 10.75

Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med (2014) 9.33

Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med (2009) 9.17

Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet (2008) 9.10

Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med (2003) 8.65

Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med (2005) 7.90

Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood (2006) 7.30

A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med (2013) 7.09

Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med (2013) 6.71

2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J (2014) 6.32

Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation (2011) 5.16

Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions. J Clin Oncol (2007) 5.12

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28

Right heart thrombi in pulmonary embolism: results from the International Cooperative Pulmonary Embolism Registry. J Am Coll Cardiol (2003) 4.10

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology (2007) 3.99

Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients. Circulation (2004) 3.83

Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation (2013) 3.73

Chronic thromboembolic pulmonary hypertension. N Engl J Med (2011) 3.37

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78

Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach. J Thorac Cardiovasc Surg (2005) 2.53

Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation (2007) 2.51

Effect of computerized clinical decision support on the use and yield of CT pulmonary angiography in the emergency department. Radiology (2011) 2.47

Cardiovascular outcomes in the Irbesartan Diabetic Nephropathy Trial of patients with type 2 diabetes and overt nephropathy. Ann Intern Med (2003) 2.47

Physical inactivity and idiopathic pulmonary embolism in women: prospective study. BMJ (2011) 2.34

Low-molecular-weight heparin and mortality in acutely ill medical patients. N Engl J Med (2011) 2.32

Massive pulmonary embolism. Circulation (2006) 2.27

Impact of achieved blood pressure on cardiovascular outcomes in the Irbesartan Diabetic Nephropathy Trial. J Am Soc Nephrol (2005) 2.25

The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis. Ann Emerg Med (2002) 2.25

Right ventricular enlargement on chest computed tomography: prognostic role in acute pulmonary embolism. Circulation (2004) 2.21

The effect of excessive anticoagulation on mortality and morbidity in hospitalized patients with anticoagulant-related major hemorrhage. Arch Intern Med (2004) 2.11

Upper-extremity deep vein thrombosis. Circulation (2002) 2.09

Upper-extremity deep vein thrombosis: a prospective registry of 592 patients. Circulation (2004) 2.05

Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: perspectives from the international, observational, prospective GARFIELD registry. PLoS One (2013) 1.97

Right ventricular enlargement on chest computed tomography: a predictor of early death in acute pulmonary embolism. Circulation (2004) 1.97

Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic review. JAMA (2005) 1.82

Gender differences in research grant applications and funding outcomes for medical school faculty. J Womens Health (Larchmt) (2008) 1.81

Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher. Arch Intern Med (2005) 1.76

The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol (2008) 1.75

Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation (2007) 1.75

Normal D-dimer levels in emergency department patients suspected of acute pulmonary embolism. J Am Coll Cardiol (2002) 1.75

Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. Virology (2004) 1.73

Cost effectiveness of thromboprophylaxis with a low-molecular-weight heparin versus unfractionated heparin in acutely ill medical inpatients. Am J Manag Care (2004) 1.69

Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism. Circulation (2003) 1.68

Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients. Circulation (2009) 1.66

Efficacy and safety of fixed low-dose dalteparin in preventing venous thromboembolism among obese or elderly hospitalized patients: a subgroup analysis of the PREVENT trial. Arch Intern Med (2005) 1.64

Surgical pulmonary embolectomy: the resurrection of an almost discarded operation. Tex Heart Inst J (2013) 1.63

Percutaneous mechanical thrombectomy for acute pulmonary embolism: a double-edged sword. Chest (2007) 1.60

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Lack of extended venous thromboembolism prophylaxis in high-risk patients undergoing major orthopaedic or major cancer surgery. Electronic Assessment of VTE Prophylaxis in High-Risk Surgical Patients at Discharge from Swiss Hospitals (ESSENTIAL). Thromb Haemost (2009) 1.58

International normalized ratio increase before warfarin-associated hemorrhage: brief and subtle. Arch Intern Med (2004) 1.55

Assessing the prognosis of acute pulmonary embolism: tricks of the trade. Chest (2008) 1.54

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm Bowel Dis (2009) 1.53

Venous thromboembolism in patients with symptomatic atherosclerosis. Thromb Haemost (2011) 1.52

Medication use evaluation: pharmacist rubric for performance improvement. Pharmacotherapy (2014) 1.52

Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes. Eur Heart J (2010) 1.51

Catheter-directed ultrasound-accelerated thrombolysis for the treatment of acute pulmonary embolism. Thromb Res (2011) 1.51

Thrombosis in suspected heparin-induced thrombocytopenia occurs more often with high antibody levels. Am J Med (2011) 1.48

De novo hepatocellular carcinoma occurring in a transplanted liver: case report and review of the literature. Dig Dis Sci (2006) 1.45

Acute pulmonary embolectomy: a contemporary approach. Circulation (2002) 1.44

Intestinal-type endocervical adenocarcinoma in situ: an immunophenotypically distinct subset of AIS affecting older women. Am J Surg Pathol (2013) 1.42

Thrombosis during pregnancy and the postpartum period. Am J Obstet Gynecol (2005) 1.42

Bleeding complications after systematic switch of routine thromboprophylaxis for major orthopaedic surgery. Thromb Haemost (2008) 1.41

Diagnosis of acute pulmonary embolism: always be vigilant. Am J Med (2007) 1.41

Epidermal growth factor receptor mutation testing in the care of lung cancer patients. Clin Cancer Res (2006) 1.40

Cardiac decortication (epicardiectomy) for occult constrictive cardiac physiology after left extrapleural pneumonectomy. Chest (2002) 1.40

Improving clinical effectiveness in thromboprophylaxis for hospitalized medical patients. Am J Med (2009) 1.39

Randomized trial of physician alerts for thromboprophylaxis after discharge. Am J Med (2013) 1.39

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39

Optimal duration of anticoagulation after venous thromboembolism: fixed and evidence-based, or flexible and personalized? Ann Intern Med (2009) 1.36

Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism. Am J Cardiol (2005) 1.34

Prognostic role of brain natriuretic peptide in acute pulmonary embolism. Circulation (2003) 1.32

Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging. J Nucl Cardiol (2007) 1.31

CT signs of right ventricular dysfunction: prognostic role in acute pulmonary embolism. JACC Cardiovasc Imaging (2011) 1.30

MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J (2011) 1.29

Multislice computed tomography for pulmonary embolism--a technological marvel. N Engl J Med (2005) 1.28

Fibrinolysis for acute pulmonary embolism. Vasc Med (2010) 1.27

Management of massive pulmonary embolism. Circulation (2005) 1.27

Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. Lab Invest (2010) 1.23

Routine pelvic and lower extremity CT venography in patients undergoing pulmonary CT angiography. AJR Am J Roentgenol (2008) 1.22

Venous thromboembolism risk and prophylaxis in hospitalised medically ill patients. The ENDORSE Global Survey. Thromb Haemost (2010) 1.21

International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD). Am Heart J (2011) 1.20

Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department: initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry). J Am Coll Cardiol (2011) 1.19

Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients. Thromb Haemost (2005) 1.19

Acute pulmonary embolism: part II: treatment and prophylaxis. Circulation (2006) 1.16

Molecular genetics of hepatocellular neoplasia. Am J Transl Res (2010) 1.16

An update on the molecular genetics of hepatocellular carcinoma. Semin Liver Dis (2004) 1.15

Molecular classification of soft tissue sarcomas and its clinical applications. Int J Clin Exp Pathol (2010) 1.15

Prospective study of BMI and the risk of pulmonary embolism in women. Obesity (Silver Spring) (2009) 1.14

Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol (2007) 1.14

Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial. Ann Intern Med (2007) 1.14

Delays in diagnosis of deep vein thrombosis and pulmonary embolism. Chest (2005) 1.13

A new approach to the diagnosis and treatment of intravascular lymphoma. J Neurooncol (2003) 1.13

Spiral computed tomography for acute pulmonary embolism. Circulation (2004) 1.12