Insulin receptor substrate proteins and diabetes.

Role of endoplasmic reticulum stress in metabolic disease and other disorders. Annu Rev Med (2012) 1.98

Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol (2006) 1.58

Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol (2013) 1.23

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol (2006) 1.16

Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling. Proc Natl Acad Sci U S A (2012) 1.12

Post-synaptic density perturbs insulin-induced Kv1.3 channel modulation via a clustering mechanism involving the SH3 domain. J Neurochem (2007) 1.12

Alzheimer's disease and insulin resistance: translating basic science into clinical applications. J Clin Invest (2013) 1.12

The UPS in diabetes and obesity. BMC Biochem (2008) 1.08

Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum. Diabetes (2007) 1.07

Insulin receptor substrates (IRSs) and breast tumorigenesis. J Mammary Gland Biol Neoplasia (2008) 1.07

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1. J Endocrinol (2010) 1.05

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway. Oncotarget (2014) 0.95

Metabolic functions of glucocorticoid receptor in skeletal muscle. Mol Cell Endocrinol (2013) 0.94

Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway. Toxicol Sci (2013) 0.90

erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines. Breast Cancer Res (2011) 0.89

Defect of insulin signal in peripheral tissues: Important role of ceramide. World J Diabetes (2014) 0.87

Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice. PLoS One (2014) 0.84

Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases. Future Sci OA (2015) 0.81

Association between IRS-2 G1057D polymorphism and risk of gastric cancer. World J Gastrointest Oncol (2012) 0.80

An informatics search for the low-molecular weight chromium-binding peptide. BMC Chem Biol (2004) 0.80

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain. J Cell Mol Med (2010) 0.80

Cell survival signaling in neuroblastoma. Anticancer Agents Med Chem (2013) 0.78

Alteration of human blood cell transcriptome in uremia. BMC Med Genomics (2013) 0.77

Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death. Exp Cell Res (2012) 0.77

Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab (2017) 0.75

Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis. PLoS One (2014) 0.75

Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation. J Biol Chem (2012) 0.75

Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma. J Hepatocell Carcinoma (2015) 0.75

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem (2001) 5.12

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem (2002) 4.84

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest (2005) 4.81

Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (2007) 4.80

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05

Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol (2005) 3.50

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab (2008) 3.22

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem (2002) 2.45

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med (2011) 2.40

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest (2004) 2.34

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med (2005) 2.18

Insulin-like signaling, nutrient homeostasis, and life span. Annu Rev Physiol (2008) 2.07

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci (2003) 2.03

Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest (2002) 1.95

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest (2002) 1.93

Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med (2009) 1.85

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest (2003) 1.83

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest (2005) 1.80

Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab (2010) 1.77

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol (2009) 1.69

Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab (2010) 1.67

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol (2008) 1.67

Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol (2004) 1.65

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun (2004) 1.59

Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal (2010) 1.59

Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol (2004) 1.55

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem (2005) 1.51

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes (2003) 1.51

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem (2003) 1.47

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol (2008) 1.40

Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem (2002) 1.34

Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes (2012) 1.32

Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res (2002) 1.32

Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem (2009) 1.31

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol (2002) 1.21

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Mol Cell Biol (2006) 1.19

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes (2004) 1.18

Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. Am J Physiol Cell Physiol (2004) 1.16

The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes (2007) 1.15

Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes (2013) 1.14

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest (2011) 1.14

Chronic activation of a designer G(q)-coupled receptor improves β cell function. J Clin Invest (2013) 1.13

Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect (2012) 1.13

Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol (2010) 1.13

Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes (2013) 1.12

The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Mol Endocrinol (2006) 1.08

Signaling pathways: the benefits of good communication. Curr Biol (2004) 1.04

Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem (2005) 1.00

Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci (2005) 1.00

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol (2007) 0.98

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (2004) 0.98

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest (2013) 0.97

IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab (2012) 0.95

The AKTion in non-canonical insulin signaling. Nat Med (2012) 0.94

Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93

Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab (2010) 0.93

Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92

Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes (2002) 0.92

Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem (2014) 0.92

Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology (2009) 0.90

Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes (2012) 0.88

Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. J Biol Chem (2013) 0.88

Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One (2013) 0.87

Foxo1 in hepatic lipid metabolism. Cell Cycle (2010) 0.87

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab (2005) 0.87

IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cereb Cortex (2011) 0.87

Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem (2005) 0.85

Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal (2013) 0.85

Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Front Biosci (2007) 0.84

Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? BMC Dev Biol (2010) 0.84

The IRS2 Gly1057Asp variant is associated with human longevity. J Gerontol A Biol Sci Med Sci (2009) 0.83

Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol (2008) 0.83

Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E. J Histochem Cytochem (2005) 0.82

Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. J Cell Physiol (2007) 0.82

Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology (2009) 0.82

Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. Am J Physiol Endocrinol Metab (2007) 0.80

Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem (2002) 0.80

Diabetes forum: Extreme makeover of pancreatic alpha-cells. Nature (2010) 0.79

Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am (2012) 0.78

Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. FEBS J (2013) 0.77

kNOXing on the door of selective insulin resistance. Arterioscler Thromb Vasc Biol (2012) 0.75

Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes (2009) 0.75

Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Lett (2003) 0.75