Published in J Biol Chem on October 17, 2001
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
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Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes (2005) 5.22
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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest (2005) 4.81
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Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol Cell Biol (2005) 3.09
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest (2007) 2.85
Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol (2009) 2.77
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol (2008) 2.73
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One (2010) 2.60
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. J Clin Invest (2012) 2.33
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
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Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia (2012) 2.05
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A (2012) 2.00
The metabolic footprint of aging in mice. Sci Rep (2011) 1.93
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One (2008) 1.90
Current views on type 2 diabetes. J Endocrinol (2009) 1.88
IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol (2009) 1.88
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci (2009) 1.88
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A (2006) 1.79
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A (2006) 1.78
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell (2011) 1.76
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest (2005) 1.76
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J (2007) 1.76
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol (2004) 1.75
Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology (2006) 1.72
Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell (2007) 1.69
The major inflammatory mediator interleukin-6 and obesity. Inflamm Res (2009) 1.67
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol (2004) 1.65
Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance. Diabetes (2008) 1.65
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med (2010) 1.64
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62
Beta-cell failure as a complication of diabetes. Rev Endocr Metab Disord (2008) 1.60
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem (2009) 1.60
The Genetic Basis of Type 2 Diabetes. Cellscience (2006) 1.58
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56
Discovery of potent and selective covalent inhibitors of JNK. Chem Biol (2012) 1.55
Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes (2008) 1.52
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50
Adipocytokines in obesity and metabolic disease. J Endocrinol (2014) 1.49
The immune system as a sensor of the metabolic state. Immunity (2013) 1.45
PPARs, Obesity, and Inflammation. PPAR Res (2007) 1.42
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41
Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol (2014) 1.38
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 1.37
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy. Scientifica (Cairo) (2012) 1.37
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci (2010) 1.36
The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol (2012) 1.35
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest (2012) 1.35
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Expression and function of the insulin receptor substrate proteins in cancer. Cell Commun Signal (2009) 1.35
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes (2008) 1.35
Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J (2014) 1.34
Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes. Diabetes (2008) 1.33
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev (2004) 1.32
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. Diabetes (2009) 1.29
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Mol Cell Biol (2004) 1.28
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. Diabetes (2009) 1.28
Activation of SOCS-3 by resistin. Mol Cell Biol (2005) 1.27
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation (2011) 1.23
Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol (2009) 1.23
Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics (2005) 1.23
Chronic high fat feeding attenuates load-induced hypertrophy in mice. J Physiol (2009) 1.22
Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis (2009) 1.21
Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats. J Endocrinol (2009) 1.20
Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J (2014) 1.20
Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice. Diabetes (2009) 1.17
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol (2006) 1.16
Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling. Endocrinology (2007) 1.15
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta. Biochem J (2004) 1.13
Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J Diabetes (2010) 1.12
Specific protein kinase C isoforms as transducers and modulators of insulin signaling. Mol Genet Metab (2006) 1.11
Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. Diabetes (2009) 1.11
Trauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha. Endocrinology (2008) 1.10
Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance. J Virol (2012) 1.09
Retracted EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes (2009) 1.08
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease. Oxid Med Cell Longev (2012) 1.07
Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum. Diabetes (2007) 1.07
Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol (2010) 1.06
Rabson-Mendenhall syndrome: two case reports and a brief review of the literature. Odontology (2010) 1.05
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury. Endocrinology (2008) 1.05
Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem (2011) 1.05
Metabolic characteristics of long-lived mice. Front Genet (2012) 1.04
Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. World J Gastroenterol (2008) 1.03
Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. Mol Metab (2014) 1.03
Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol Biol Cell (2008) 1.03
Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochem Biophys Res Commun (2009) 1.02
Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance. Hepatology (2009) 1.02
Type 2 diabetes is associated with altered NF-κB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS. PLoS One (2011) 1.00
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem (2002) 4.84
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest (2005) 4.81
Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (2007) 4.80
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol (2005) 3.50
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab (2008) 3.22
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem (2002) 2.45
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med (2011) 2.40
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest (2004) 2.34
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med (2005) 2.18
Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem (2006) 2.15
Insulin-like signaling, nutrient homeostasis, and life span. Annu Rev Physiol (2008) 2.07
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci (2003) 2.03
Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest (2002) 1.95
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest (2002) 1.93
Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med (2009) 1.85
Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem (2004) 1.84
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest (2003) 1.83
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest (2005) 1.80
Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab (2010) 1.77
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol (2009) 1.69
Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol (2008) 1.67
Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab (2010) 1.67
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol (2004) 1.65
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun (2004) 1.59
Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal (2010) 1.59
Structure of the globular tail of nuclear lamin. J Biol Chem (2002) 1.58
Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol (2004) 1.55
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem (2005) 1.51
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes (2003) 1.51
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem (2011) 1.48
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem (2003) 1.47
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS One (2012) 1.43
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci U S A (2008) 1.42
Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer. Biochem Biophys Res Commun (2004) 1.41
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol (2008) 1.40
Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation. Gene (2005) 1.35
Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem (2002) 1.34
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem (2002) 1.34
Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes (2012) 1.32
Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res (2002) 1.32
Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem (2009) 1.31
Kinase activation through dimerization by human SH2-B. Mol Cell Biol (2005) 1.22
Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol (2002) 1.21
Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Mol Cell Biol (2006) 1.19
Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo. J Bone Miner Res (2010) 1.18
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes (2004) 1.18
Nodular histiocytic hyperplasia of the endometrium. Int J Gynecol Pathol (2002) 1.16
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. Am J Physiol Cell Physiol (2004) 1.16
The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes (2007) 1.15
Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes (2013) 1.14
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest (2011) 1.14
Chronic activation of a designer G(q)-coupled receptor improves β cell function. J Clin Invest (2013) 1.13
Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect (2012) 1.13
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol (2010) 1.13
Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes (2013) 1.12
Insulin receptor substrate proteins and diabetes. Arch Pharm Res (2004) 1.12
A combination trial of intradermal radiofrequency and hyaluronic acid filler for the treatment of nasolabial fold wrinkles: a pilot study. J Cosmet Laser Ther (2013) 1.11
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Mol Endocrinol (2006) 1.08
Unilateral breast edema: spectrum of etiologies and imaging appearances. Yonsei Med J (2005) 1.04
Signaling pathways: the benefits of good communication. Curr Biol (2004) 1.04
Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem (2005) 1.00
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci (2005) 1.00
A phenylalanine zipper mediates APS dimerization. Nat Struct Mol Biol (2004) 0.99
Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu. J Biol Chem (2004) 0.99
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. J Cell Biol (2003) 0.99
Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol (2007) 0.98
IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (2004) 0.98
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest (2013) 0.97
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab (2012) 0.95
The AKTion in non-canonical insulin signaling. Nat Med (2012) 0.94
Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab (2010) 0.93
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes (2002) 0.92
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem (2014) 0.92
Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology (2009) 0.90
Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. J Biol Chem (2013) 0.88
Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes (2012) 0.88
Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One (2013) 0.87
Foxo1 in hepatic lipid metabolism. Cell Cycle (2010) 0.87
IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cereb Cortex (2011) 0.87
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab (2005) 0.87
Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol (2009) 0.87
Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. Mod Pathol (2003) 0.86
Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem (2005) 0.85
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal (2013) 0.85
Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Front Biosci (2007) 0.84
Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? BMC Dev Biol (2010) 0.84
The IRS2 Gly1057Asp variant is associated with human longevity. J Gerontol A Biol Sci Med Sci (2009) 0.83
Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol (2008) 0.83
Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E. J Histochem Cytochem (2005) 0.82
Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology (2009) 0.82
Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. J Cell Physiol (2007) 0.82
The effect of virtual reality cognitive training for attention enhancement. Cyberpsychol Behav (2002) 0.80