Published in J Invest Dermatol on July 01, 2004
Periodontitis and diabetes: a two-way relationship. Diabetologia (2011) 2.27
The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol (2008) 2.21
Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J Dent Res (2006) 1.54
Obesity and lung inflammation. J Appl Physiol (1985) (2009) 1.42
Diabetic complications and dysregulated innate immunity. Front Biosci (2008) 1.28
Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing. Am J Pathol (2006) 1.25
Hyper-responsive phenotype in localized aggressive periodontitis. J Dent Res (2009) 1.23
Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLoS One (2011) 1.13
Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J (2011) 1.09
Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol (2006) 1.02
Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res (2012) 1.01
Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus. PLoS One (2012) 0.96
Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis. J Leukoc Biol (2014) 0.94
B cells as under-appreciated mediators of non-auto-immune inflammatory disease. Cytokine (2010) 0.93
Odontogenic infection involving the secondary fascial space in diabetic and non-diabetic patients: a clinical comparative study. J Korean Assoc Oral Maxillofac Surg (2013) 0.91
Spontaneous periodontitis development in diabetic rats involves an unrestricted expression of inflammatory cytokines and tissue destructive factors in the absence of major changes in commensal oral microbiota. Exp Diabetes Res (2012) 0.91
Diabetes mellitus related bone metabolism and periodontal disease. Int J Oral Sci (2015) 0.88
The enduring importance of animal models in understanding periodontal disease. Virulence (2015) 0.87
Glucose toxic effects on granulation tissue productive cells: the diabetics' impaired healing. Biomed Res Int (2012) 0.87
Burkholderia pseudomallei triggers altered inflammatory profiles in a whole-blood model of type 2 diabetes-melioidosis comorbidity. Infect Immun (2012) 0.86
P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers. J Periodontol (2008) 0.85
Delayed activation of host innate immune pathways in streptozotocin-induced diabetic hosts leads to more severe disease during infection with Burkholderia pseudomallei. Immunology (2012) 0.83
Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis. Infect Immun (2012) 0.83
Treating chronic periodontitis: current status, challenges, and future directions. Clin Cosmet Investig Dent (2010) 0.82
Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus. J Neuroinflammation (2014) 0.82
Hyperglycemia induced and intrinsic alterations in type 2 diabetes-derived osteoclast function. Oral Dis (2013) 0.82
Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes. Int J Clin Exp Med (2008) 0.81
Hyperglycemia in streptozotocin-induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase-1. Mediators Inflamm (2006) 0.81
Alloxan-induced diabetes triggers the development of periodontal disease in rats. PLoS One (2007) 0.80
Alveolar bone protective and hypoglycemic effects of systemic propolis treatment in experimental periodontitis and diabetes mellitus. J Med Food (2014) 0.80
Gene expression dynamics during diabetic periodontitis. J Dent Res (2012) 0.78
Anti-Diabetic Effect of Portulaca oleracea L. Polysaccharideandits Mechanism in Diabetic Rats. Int J Mol Sci (2016) 0.77
Psychoneuroimmune implications of type 2 diabetes: redux. Immunol Allergy Clin North Am (2009) 0.76
Green Tea Modulates Cytokine Expression in the Periodontium and Attenuates Alveolar Bone Resorption in Type 1 Diabetic Rats. PLoS One (2015) 0.76
Ocular inflammation in uveal tract in aged obese type 2 diabetic rats (Spontaneously Diabetic Torii fatty rats). J Diabetes Res (2014) 0.75
Oral Manifestations of Diabetes. Clin Diabetes (2016) 0.75
Analysis of glycosylated hemoglobin (HbA1c) level on maxillofacial fascial space infection in diabetic patients. J Korean Assoc Oral Maxillofac Surg (2015) 0.75
Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem (2003) 4.34
Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation (2004) 1.82
Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun (2005) 1.77
Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J Bone Miner Res (2009) 1.68
Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity. J Bone Miner Res (2007) 1.67
FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem (2005) 1.63
Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol (2008) 1.61
Three-dimensional reconstruction of fracture callus morphogenesis. J Histochem Cytochem (2006) 1.48
Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways. Bone (2006) 1.44
Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology (2003) 1.41
A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes (2003) 1.34
Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1. J Biol Chem (2011) 1.31
Role of forkhead transcription factors in diabetes-induced oxidative stress. Exp Diabetes Res (2012) 1.27
FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes (2009) 1.25
Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing. Am J Pathol (2006) 1.25
Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss. Endocrinology (2003) 1.25
FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress. J Cell Biol (2013) 1.22
High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing. Am J Pathol (2009) 1.20
Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways. J Biol Chem (2004) 1.18
Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor. Am J Physiol Cell Physiol (2006) 1.16
Diabetes alters the response to bacteria by enhancing fibroblast apoptosis. Endocrinology (2004) 1.12
Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen. J Immunol (2008) 1.11
TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1. J Bone Miner Res (2010) 1.11
Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone (2008) 1.10
Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. J Infect Dis (2002) 1.10
The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. FASEB J (2008) 1.09
Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J (2011) 1.09
Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes (2006) 1.08
FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis (2010) 1.04
Abnormal cell responses and role of TNF-α in impaired diabetic wound healing. Biomed Res Int (2013) 1.02
FOXO1 modulates osteoblast differentiation. Bone (2011) 0.99
Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology (2004) 0.97
TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes. J Cell Physiol (2004) 0.97
Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing. J Immunol (2004) 0.95
Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun (2002) 0.93
Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts. J Biol Chem (2003) 0.92
Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res (2005) 0.92
Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone (2012) 0.91
A long-term siRNA strategy regulates fibronectin overexpression and improves vascular lesions in retinas of diabetic rats. Mol Vis (2011) 0.89
The enduring importance of animal models in understanding periodontal disease. Virulence (2015) 0.87
Healing is delayed in oral compared to dermal excisional wounds. J Periodontol (2003) 0.87
P. gingivalis modulates keratinocytes through FOXO transcription factors. PLoS One (2013) 0.86
Diabetes and Its Effect on Bone and Fracture Healing. Curr Osteoporos Rep (2015) 0.86
P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers. J Periodontol (2008) 0.85
Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes. J Clin Endocrinol Metab (2012) 0.85
Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients. J Periodontol (2003) 0.84
Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun (2006) 0.84
A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium. J Clin Periodontol (2012) 0.83
Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. Am J Pathol (2013) 0.83
Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis. Infect Immun (2012) 0.83
Diabetes and oral disease: implications for health professionals. Ann N Y Acad Sci (2012) 0.81
Clopidogrel enhances periodontal repair in rats through decreased inflammation. J Clin Periodontol (2014) 0.81
Fibroblast apoptosis induced by Porphyromonas gingivalis is stimulated by a gingipain and caspase-independent pathway that involves apoptosis-inducing factor. Cell Microbiol (2007) 0.80
Locally delivered salicylic acid from a poly(anhydride-ester): impact on diabetic bone regeneration. J Control Release (2013) 0.79
Evidence that diabetes mellitus aggravates periodontal diseases and modifies the response to an oral pathogen in animal models. Compend Contin Educ Dent (2004) 0.79
Cellular and Molecular Aspects of Bone Remodeling. Front Oral Biol (2015) 0.78
Bone Remodeling Under Pathological Conditions. Front Oral Biol (2015) 0.77
Addendum: Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB. Nat Med (2015) 0.75