Published in J Biol Chem on June 11, 2004
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol (2006) 2.28
A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev (2009) 1.98
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol Cell Biol (2006) 1.39
Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem (2009) 1.36
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology (2007) 1.35
Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene. Proc Natl Acad Sci U S A (2007) 1.33
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res (2008) 1.30
Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. J Virol (2008) 1.25
Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells. Glia (2009) 1.15
Histone deacetylase (HDAC) activity is critical for embryonic kidney gene expression, growth, and differentiation. J Biol Chem (2011) 1.14
PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J (2011) 1.13
Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells. J Biol Chem (2010) 1.12
A novel form of human STAT1 deficiency impairing early but not late responses to interferons. Blood (2010) 1.11
Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. J Neuroimmune Pharmacol (2010) 1.08
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. J Immunol (2010) 1.05
Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway. JAKSTAT (2013) 1.04
Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming. Stem Cells Int (2012) 1.02
Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. BMC Dev Biol (2007) 1.02
Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells. Mol Cancer (2010) 1.01
Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma. J Interferon Cytokine Res (2009) 0.95
Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals. Blood (2011) 0.94
The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc Natl Acad Sci U S A (2012) 0.94
Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus. PLoS Pathog (2015) 0.91
Proximal genomic localization of STAT1 binding and regulated transcriptional activity. BMC Genomics (2006) 0.90
Histone deacetylases inhibit IFN-gamma-inducible gene expression in mouse trophoblast cells. J Immunol (2009) 0.84
Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor. Int J Cancer (2009) 0.84
Exploiting tumor epigenetics to improve oncolytic virotherapy. Front Genet (2013) 0.84
A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. J Virol (2013) 0.83
Class I histone deacetylase Thd1p promotes global chromatin condensation in Tetrahymena thermophila. Eukaryot Cell (2007) 0.83
STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis. JAKSTAT (2013) 0.80
Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection. J Virol (2013) 0.79
Chromium(VI) stimulates Fyn to initiate innate immune gene induction in human airway epithelial cells. Chem Res Toxicol (2010) 0.78
From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research. Front Neurosci (2016) 0.77
Influenza A Virus Dysregulates Host Histone Deacetylase 1 That Inhibits Viral Infection in Lung Epithelial Cells. J Virol (2016) 0.77
Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses. J Exp Med (2016) 0.77
Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I. Nucleic Acids Res (2014) 0.76
Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection. Oncotarget (2016) 0.75
Optimized logic-rules reveal IFN-γ induced modes regulated by histone deacetylases and protein tyrosine phosphatases. Immunology (2017) 0.75
Histone Deacetylase 2 Is a Component of Influenza A Virus-Induced Host Antiviral Response. Front Microbiol (2017) 0.75
Function of mitochondrial Stat3 in cellular respiration. Science (2009) 5.13
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science (2009) 3.89
Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species. J Biol Chem (2011) 1.40
Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem (2006) 1.23
Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3. Mitochondrion (2011) 1.17
Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab (2005) 1.16
Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727. J Biol Chem (2013) 1.12
The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem (2012) 1.08
Multi-tasking: nuclear transcription factors with novel roles in the mitochondria. Trends Cell Biol (2012) 1.05
Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab (2012) 0.97
A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion. J Leukoc Biol (2003) 0.97
Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes. Mol Cell Biol (2006) 0.95
Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells. J Biol Chem (2003) 0.89
Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation. J Biol Chem (2004) 0.86
Type I interferons activate apoptosis in a Jurkat cell variant by caspase-dependent and independent mechanisms. Cell Signal (2005) 0.80
Thrombomodulin RNA is destabilized through its 3'-untranslated element in cells exposed to IFN-gamma. J Interferon Cytokine Res (2003) 0.79
The role of Tyk2 in regulation of breast cancer growth. J Interferon Cytokine Res (2011) 0.77