Published in Methods Mol Biol on January 01, 2004
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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron (2009) 2.43
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Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment. J Biol Chem (2009) 1.37
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Formation and toxicity of soluble polyglutamine oligomers in living cells. PLoS One (2010) 1.12
Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure. J Mol Biol (2012) 0.99
Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.97
Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract. Elife (2016) 0.77
Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity. Acta Crystallogr F Struct Biol Commun (2016) 0.75
Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nat Chem Biol (2011) 2.24
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc Natl Acad Sci U S A (2010) 1.65
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration. Nat Chem Biol (2013) 1.52
Thyroidectomy using local anesthesia: a report of 1,025 cases over 16 years. J Am Coll Surg (2005) 1.32
Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis. J Neurosci (2010) 1.25
Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Hum Mol Genet (2010) 1.17
Thyroidectomy using monitored local or conventional general anesthesia: an analysis of outpatient surgery, outcome and cost in 1,194 consecutive cases. World J Surg (2006) 1.17
Next generation of growth-sparing techniques: preliminary clinical results of a magnetically controlled growing rod in 14 patients with early-onset scoliosis. Spine (Phila Pa 1976) (2013) 1.15
Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure. J Mol Biol (2012) 0.99
Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.97
Genome-wide copy number analysis uncovers a new HSCR gene: NRG3. PLoS Genet (2012) 0.90
Implant Complications After Magnetically Controlled Growing Rods for Early Onset Scoliosis: A Multicenter Retrospective Review. J Pediatr Orthop (2017) 0.89
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy. J Neurooncol (2006) 0.83
New pathways for evaluating potential acute stroke therapies. Int J Stroke (2006) 0.82
Clinical protocol. Intra-Lesional rF-B7.1 versus rF-TRICOM vaccine in the treatment of metastatic cancer. Hum Gene Ther (2003) 0.78
A two-hybrid screening of human Tau protein: interactions with Alu-derived domain. Neuroreport (2002) 0.77
Genitopatellar syndrome: a case report of a rare entity with 11 years of follow-up. J Pediatr Orthop B (2013) 0.75