Published in Free Radic Biol Med on July 15, 2004
Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res (2007) 1.45
alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis (2007) 1.36
Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. Am J Physiol Lung Cell Mol Physiol (2008) 1.17
Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. J Biol Chem (2008) 1.04
Regulating survival and development in the retina: key roles for simple sphingolipids. J Lipid Res (2010) 1.02
Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders. Surv Ophthalmol (2013) 0.96
Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2008) 0.92
Mouse hepatic oval cells require Met-dependent PI3K to impair TGF-β-induced oxidative stress and apoptosis. PLoS One (2013) 0.92
Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis. J Toxicol (2009) 0.88
Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res (2009) 0.85
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2009) 0.85
Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol (2010) 0.82
Ceramide signaling in retinal degeneration. Adv Exp Med Biol (2012) 0.81
Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells. J Clin Invest (2012) 0.81
Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Exp Eye Res (2008) 0.80
Acetylcholinesterase function in apoptotic retina pigment epithelial cells induced by H2O2. Int J Ophthalmol (2013) 0.78
Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine expression. Exp Eye Res (2011) 0.78
Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells. Cytokine (2014) 0.75
Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal (2013) 0.75
Oxidative stress in myopia. Oxid Med Cell Longev (2015) 0.75
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol (2002) 2.27
alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood (2009) 2.10
WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell (2011) 2.06
A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc (2009) 1.91
Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis. J Immunol (2003) 1.60
Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Invest Ophthalmol Vis Sci (2013) 1.59
Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis (2006) 1.50
Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol (2007) 1.48
Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis. J Neurosci Res (2006) 1.37
In vivo models of proliferative vitreoretinopathy. Nat Protoc (2007) 1.36
The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol (2008) 1.36
alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis (2007) 1.36
Neutrophils promote experimental choroidal neovascularization. Mol Vis (2005) 1.35
Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci (2013) 1.30
Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY) (2009) 1.28
αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One (2010) 1.27
Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest (2005) 1.26
Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol (2003) 1.26
Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol (2004) 1.24
Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophthalmol Vis Sci (2002) 1.18
Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci (2011) 1.18
Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2010) 1.17
Novel roles for α-crystallins in retinal function and disease. Prog Retin Eye Res (2012) 1.17
A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol (2003) 1.16
N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci (2008) 1.15
Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis. J Virol (2008) 1.14
Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci (2008) 1.11
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci (2013) 1.11
Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol (2006) 1.10
CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS. Eur J Immunol (2006) 1.10
Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J Virol (2005) 1.10
Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol (2006) 1.10
A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res (2012) 1.10
RNase L mediated protection from virus induced demyelination. PLoS Pathog (2009) 1.10
Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis (2006) 1.10
BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem (2009) 1.07
Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res (2007) 1.07
CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol (2011) 1.05
Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol (2009) 1.05
Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res (2006) 1.05
Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci (2005) 1.04
CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis. J Virol (2011) 1.03
Factors supporting intrathecal humoral responses following viral encephalomyelitis. J Virol (2010) 1.03
Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med (2012) 1.02
Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am J Pathol (2010) 1.02
CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. J Virol (2007) 1.01
Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J Virol (2002) 1.00
Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci (2009) 1.00
Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells. Virology (2006) 1.00
Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol (2005) 1.00
Optical coherence tomography findings in idiopathic juxtafoveal retinal telangiectasis. Graefes Arch Clin Exp Ophthalmol (2006) 1.00
MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina (2006) 1.00
Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun (2005) 1.00
Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci (2003) 0.99
ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A (2012) 0.99
IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability. PLoS One (2012) 0.97
Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. J Immunol (2010) 0.95
Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration. J Neurosurg (2010) 0.95
Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis (2012) 0.94
Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS One (2012) 0.93
Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. Ophthalmology (2007) 0.93
Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis. J Virol (2011) 0.93
Mouse strain-dependent heterogeneity of resting limbal vasculature. Invest Ophthalmol Vis Sci (2004) 0.93
Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2008) 0.92
Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Invest Ophthalmol Vis Sci (2004) 0.91
What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence. Aging (Albany NY) (2009) 0.91
Review: Epigenetic mechanisms in ocular disease. Mol Vis (2013) 0.91
Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε. J Biol Chem (2012) 0.91
GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J (2012) 0.89
Differential regulation of primary and secondary CD8+ T cells in the central nervous system. J Immunol (2004) 0.89
Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci (2006) 0.88
Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. FASEB J (2011) 0.88
Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages. J Virol (2013) 0.88
Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes. Glia (2005) 0.88
Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. J Virol (2013) 0.87
Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFβ2 and its receptor TGFβRII. Invest Ophthalmol Vis Sci (2011) 0.87
Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci (2005) 0.85
Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochem Biophys Res Commun (2011) 0.85
Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro. Invest Ophthalmol Vis Sci (2011) 0.85
Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res (2009) 0.85
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2009) 0.85
Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis. J Neuroinflammation (2012) 0.85
Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2. Viral Immunol (2005) 0.85
Astrocyte expression of a dominant-negative interferon-gamma receptor. J Neurosci Res (2005) 0.84
A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol (2005) 0.84
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. J Neuroinflammation (2012) 0.84
Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res (2010) 0.84
Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao (2006) 0.83
Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection. J Virol (2009) 0.83
Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci (2011) 0.83
In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance. Ophthalmic Surg Lasers Imaging Retina (2013) 0.82
VEGF and PEDF secretion in ARPE-19 and fhRPE cells. Invest Ophthalmol Vis Sci (2011) 0.82
Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol (2012) 0.82
Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol (2010) 0.82
Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system. Virology (2013) 0.81