DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

PubWeight™: 3.90‹?› | Rank: Top 1%

🔗 View Article (PMC 3077055)

Published in Nature on February 06, 2011

Authors

Hiroki Kaneko1, Sami Dridi, Valeria Tarallo, Bradley D Gelfand, Benjamin J Fowler, Won Gil Cho, Mark E Kleinman, Steven L Ponicsan, William W Hauswirth, Vince A Chiodo, Katalin Karikó, Jae Wook Yoo, Dong-ki Lee, Majda Hadziahmetovic, Ying Song, Smita Misra, Gautam Chaudhuri, Frank W Buaas, Robert E Braun, David R Hinton, Qing Zhang, Hans E Grossniklaus, Jan M Provis, Michele C Madigan, Ann H Milam, Nikki L Justice, Romulo J C Albuquerque, Alexander D Blandford, Sasha Bogdanovich, Yoshio Hirano, Jassir Witta, Elaine Fuchs, Dan R Littman, Balamurali K Ambati, Charles M Rudin, Mark M W Chong, Patrick Provost, Jennifer F Kugel, James A Goodrich, Joshua L Dunaief, Judit Z Baffi, Jayakrishna Ambati

Author Affiliations

1: Department of Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.

Articles citing this

(truncated to the top 100)

Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal. Cell Cycle (2011) 3.11

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73

Mechanisms of age-related macular degeneration. Neuron (2012) 2.62

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci (2012) 2.52

Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol Aspects Med (2012) 2.37

A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy. Cell (2012) 2.29

Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29

Immunology of age-related macular degeneration. Nat Rev Immunol (2013) 2.14

Aicardi-Goutières syndrome and the type I interferonopathies. Nat Rev Immunol (2015) 1.82

Human transposon tectonics. Cell (2012) 1.81

Alu elements: know the SINEs. Genome Biol (2011) 1.81

Virus-encoded microRNAs: an overview and a look to the future. PLoS Pathog (2012) 1.80

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (2014) 1.77

Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA. Nat Struct Mol Biol (2014) 1.76

Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab (2012) 1.52

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing. RNA (2011) 1.52

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. Nat Rev Drug Discov (2012) 1.52

The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning. Neuron (2016) 1.48

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Med (2012) 1.46

Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy. Ophthalmology (2013) 1.43

Activation of transposable elements during aging and neuronal decline in Drosophila. Nat Neurosci (2013) 1.43

The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis. J Biol Chem (2012) 1.34

Aging is not a disease: distinguishing age-related macular degeneration from aging. Prog Retin Eye Res (2013) 1.29

MicroRNAs and fibrosis. Curr Opin Nephrol Hypertens (2012) 1.28

IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med (2014) 1.27

Uncovering the role of genomic "dark matter" in human disease. J Clin Invest (2012) 1.26

Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp Eye Res (2011) 1.25

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ (2013) 1.23

Dicer is required for haploid male germ cell differentiation in mice. PLoS One (2011) 1.20

NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration. Cell Rep (2013) 1.18

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics. Mol Aspects Med (2012) 1.16

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues. Nucleic Acids Res (2013) 1.12

Association between geographic atrophy progression and reticular pseudodrusen in eyes with dry age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.11

TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci (2013) 1.11

Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS One (2012) 1.10

Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. PLoS One (2011) 1.10

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Mol Ther (2011) 1.09

In vivo imaging of retinal pigment epithelium cells in age related macular degeneration. Biomed Opt Express (2013) 1.09

Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells. Nat Struct Mol Biol (2012) 1.08

Genetic studies of age-related macular degeneration: lessons, challenges, and opportunities for disease management. Ophthalmology (2012) 1.07

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife (2013) 1.06

The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs. RNA (2014) 1.06

The Project MACULA Retinal Pigment Epithelium Grading System for Histology and Optical Coherence Tomography in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci (2015) 1.05

Genetics of immunological and inflammatory components in age-related macular degeneration. Ocul Immunol Inflamm (2012) 1.04

Transposable elements in TDP-43-mediated neurodegenerative disorders. PLoS One (2012) 1.04

Non-coding RNAs in retinal development. Int J Mol Sci (2012) 1.04

DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nat Struct Mol Biol (2012) 1.03

"Seq-ing" insights into the epigenetics of neuronal gene regulation. Neuron (2013) 1.03

Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy. Neurotherapeutics (2013) 1.02

Mobile elements in the human genome: implications for disease. Genome Med (2012) 1.02

Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs. Nat Neurosci (2012) 1.02

Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs. Genes Dev (2012) 1.01

The role of transposable elements in health and diseases of the central nervous system. J Neurosci (2013) 1.01

Chromatin structure and transposable elements in organismal aging. Front Genet (2013) 1.00

Transposable elements modulate human RNA abundance and splicing via specific RNA-protein interactions. Genome Biol (2014) 1.00

ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A (2012) 0.99

The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci (2012) 0.98

Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex. Mol Cell Neurosci (2012) 0.98

A repetitive elements perspective in Polycomb epigenetics. Front Genet (2012) 0.97

Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest Ophthalmol Vis Sci (2014) 0.95

Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives. Front Neurosci (2012) 0.94

miRNAs at the interface of cellular stress and disease. EMBO J (2014) 0.93

Protection of retina by αB crystallin in sodium iodate induced retinal degeneration. PLoS One (2014) 0.93

Roles for retrotransposon insertions in human disease. Mob DNA (2016) 0.92

Nuclear noncoding RNA surveillance: is the end in sight? Trends Genet (2012) 0.92

Induced pluripotent stem cell therapies for geographic atrophy of age-related macular degeneration. Semin Ophthalmol (2011) 0.92

Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration. Hum Mol Genet (2011) 0.92

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology (2013) 0.92

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease. Adv Exp Med Biol (2014) 0.92

Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion. PLoS One (2013) 0.92

Alu element-containing RNAs maintain nucleolar structure and function. EMBO J (2015) 0.91

Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration. PLoS One (2014) 0.91

Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res (2013) 0.91

Review: Epigenetic mechanisms in ocular disease. Mol Vis (2013) 0.91

RPE necroptosis in response to oxidative stress and in AMD. Ageing Res Rev (2015) 0.91

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer. Open Biol (2013) 0.91

Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease. Prog Retin Eye Res (2015) 0.90

Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2014) 0.90

Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants. Cell Rep (2014) 0.90

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. J Biol Chem (2014) 0.90

Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Hum Genomics (2012) 0.90

NLRP3 inflammasome: activation and regulation in age-related macular degeneration. Mediators Inflamm (2015) 0.90

The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity. Philos Trans R Soc Lond B Biol Sci (2014) 0.89

Functional impact of the human mobilome. Curr Opin Genet Dev (2013) 0.89

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A (2014) 0.88

Age-related macular degeneration and the other double helix. The Cogan Lecture. Invest Ophthalmol Vis Sci (2011) 0.88

Non-coding RNAs in the development of sensory organs and related diseases. Cell Mol Life Sci (2013) 0.88

Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells. PLoS One (2012) 0.88

Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention. Am J Ophthalmol (2014) 0.88

Good news-bad news: the Yin and Yang of immune privilege in the eye. Front Immunol (2012) 0.88

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J (2015) 0.88

SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation. Nat Commun (2015) 0.87

DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J (2014) 0.87

miRNAs as potential therapeutic targets for age-related macular degeneration. Future Med Chem (2012) 0.87

Interaction of complement factor h and fibulin3 in age-related macular degeneration. PLoS One (2013) 0.86

Functional microRNAs and target sites are created by lineage-specific transposition. Hum Mol Genet (2013) 0.86

Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism. Mol Immunol (2012) 0.86

Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance. J Biol Chem (2015) 0.85

Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol (2013) 0.85

Articles cited by this

Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75

Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86

The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44

Alu repeats and human genomic diversity. Nat Rev Genet (2002) 12.40

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

The colorectal microRNAome. Proc Natl Acad Sci U S A (2006) 11.59

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature (2008) 10.11

Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00

Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77

Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07

Annotation, submission and screening of repetitive elements in Repbase: RepbaseSubmitter and Censor. BMC Bioinformatics (2006) 5.50

Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol (2003) 5.22

Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev (2009) 5.21

Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell (2007) 5.19

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev (2007) 4.69

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (1985) 4.51

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00

DICER1 mutations in familial pleuropulmonary blastoma. Science (2009) 3.82

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33

Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell (1987) 3.31

A de novo Alu insertion results in neurofibromatosis type 1. Nature (1991) 3.29

Recombination at the human alpha-globin gene cluster: sequence features and topological constraints. Cell (1987) 3.21

The role of apoptosis in age-related macular degeneration. Arch Ophthalmol (2002) 3.10

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol (2006) 2.83

Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev (2009) 2.73

The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock. Nat Struct Mol Biol (2004) 2.71

Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science (2010) 2.66

Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50

DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49

Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med (1995) 2.40

CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature (2009) 2.39

Monoclonal antibodies to double-stranded RNA as probes of RNA structure in crude nucleic acid extracts. Nucleic Acids Res (1991) 1.92

Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev (2010) 1.67

Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene (2009) 1.50

Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat Med (2010) 1.45

Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J Exp Med (2010) 1.40

Essential role for Argonaute2 protein in mouse oogenesis. Epigenetics Chromatin (2009) 1.36

cDNAs derived from primary and small cytoplasmic Alu (scAlu) transcripts. J Mol Biol (1997) 1.27

Expression and modulation of RPE cell membrane complement regulatory proteins. Invest Ophthalmol Vis Sci (2009) 1.22

Generation of Cre transgenic mice with postnatal RPE-specific ocular expression. Invest Ophthalmol Vis Sci (2011) 1.18

Adeno-associated viral vectors and the retina. Adv Exp Med Biol (2008) 1.10

SINE and LINE within human centromeres. J Mol Evol (1996) 0.85

Articles by these authors

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17

Defining the epithelial stem cell niche in skin. Science (2003) 14.93

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. N Engl J Med (2015) 12.54

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med (2004) 11.71

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79

Interactions between the microbiota and the immune system. Science (2012) 10.45

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59

Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med (2009) 8.55

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08

Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema. Nucleic Acids Res (2005) 7.81

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc Natl Acad Sci U S A (2008) 7.16

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10

Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med (2012) 6.90

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med (2006) 6.86

Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med (2003) 6.61

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30

A muscleblind knockout model for myotonic dystrophy. Science (2003) 5.93

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet (2004) 5.75

A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science (2009) 5.40

A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods (2002) 5.30

Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol (2003) 5.22

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol (2004) 5.06

Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

Sticky business: orchestrating cellular signals at adherens junctions. Cell (2003) 4.91

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90

Links between signal transduction, transcription and adhesion in epithelial bud development. Nature (2003) 4.88

Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A (2002) 4.85

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78

Corneal avascularity is due to soluble VEGF receptor-1. Nature (2006) 4.77

Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther (2005) 4.74

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity (2002) 4.62

Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov (2011) 4.60

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46

Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem (2004) 4.40

Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29

Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27

Inadvertent evisceration of eyes containing uveal melanoma. Arch Ophthalmol (2009) 4.25

Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock. Mol Cell (2008) 4.24

Biventricular pacing in patients with bradycardia and normal ejection fraction. N Engl J Med (2009) 4.17

The complete genome sequence of Mycobacterium avium subspecies paratuberculosis. Proc Natl Acad Sci U S A (2005) 4.16

Dynamics between stem cells, niche, and progeny in the hair follicle. Cell (2011) 4.14

Epithelial stem cells: turning over new leaves. Cell (2007) 4.10

Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A (2009) 4.10

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res (2011) 4.05

Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A (2005) 4.04

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev Cell (2002) 4.01

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell (2011) 3.88

Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88

Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86

PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest (2004) 3.86

NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79