Published in Blood on June 17, 2004
Reliability of antimalarial sensitivity tests depends on drug mechanisms of action. J Clin Microbiol (2010) 1.43
A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. BMC Genomics (2008) 1.27
An improved and highly sensitive microfluorimetric method for assessing susceptibility of Plasmodium falciparum to antimalarial drugs in vitro. Malar J (2006) 1.16
The plasmodial surface anion channel is functionally conserved in divergent malaria parasites. Eukaryot Cell (2005) 1.14
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. J Antimicrob Chemother (2013) 1.07
Symmetrical choline-derived dications display strong anti-kinetoplastid activity. J Antimicrob Chemother (2010) 1.01
Targeting the Lipid Metabolic Pathways for the Treatment of Malaria. Drug Dev Res (2010) 0.98
Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. Antimicrob Agents Chemother (2006) 0.96
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. Prog Lipid Res (2013) 0.96
Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum. Mol Biochem Parasitol (2008) 0.93
Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial mechanism. Antimicrob Agents Chemother (2006) 0.91
Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite. Malar J (2009) 0.90
Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways. J Lipid Res (2010) 0.90
Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate. Br J Pharmacol (2012) 0.86
Transport proteins of parasitic protists and their role in nutrient salvage. Front Plant Sci (2014) 0.84
1H-NMR metabolite profiles of different strains of Plasmodium falciparum. Biosci Rep (2014) 0.83
Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives. Antimicrob Agents Chemother (2009) 0.79
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLoS Pathog (2015) 0.78
PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity. J Biol Chem (2011) 0.78
Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways. BMC Syst Biol (2013) 0.75
Plasmodium falciparum: sacrificing membrane to grow crystals? Trends Parasitol (2003) 2.96
The molecular mechanism of action of artemisinin--the debate continues. Molecules (2010) 2.57
The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol (2007) 2.54
A class of potent antimalarials and their specific accumulation in infected erythrocytes. Science (2002) 2.27
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. EMBO J (2005) 2.09
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Mol Cell (2004) 2.02
Coartem (artemether-lumefantrine) in Africa: the beginning of the end? J Infect Dis (2005) 2.00
New Zealand National GDM Guidelines: an alternative view of some good practice points. Aust N Z J Obstet Gynaecol (2015) 1.97
Family support in children's mental health: a review and synthesis. Clin Child Fam Psychol Rev (2010) 1.93
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends Parasitol (2003) 1.74
Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Mol Microbiol (2005) 1.64
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. Insect Biochem Mol Biol (2011) 1.59
Recent highlights in antimalarial drug resistance and chemotherapy research. Trends Parasitol (2008) 1.52
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother (2010) 1.42
Diamidines for human African trypanosomiasis. Curr Opin Investig Drugs (2010) 1.42
How well is cognitive function documented by medical staff in the over-65 age group at the time of acute medical admission? N Z Med J (2010) 1.39
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proc Natl Acad Sci U S A (2012) 1.34
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Mol Microbiol (2006) 1.33
Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase. J Biol Chem (2002) 1.28
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. J Biol Chem (2007) 1.27
In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolism. Antimicrob Agents Chemother (2003) 1.25
Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex. Mol Pharmacol (2008) 1.22
Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Acc Chem Res (2004) 1.21
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria. Antimicrob Agents Chemother (2006) 1.21
Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP. AIDS (2005) 1.20
Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo. J Exp Med (2011) 1.20
Inhibiting Plasmodium cytochrome bc1: a complex issue. Curr Opin Chem Biol (2010) 1.19
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. J Antimicrob Chemother (2013) 1.18
Heme binding contributes to antimalarial activity of bis-quaternary ammoniums. Antimicrob Agents Chemother (2003) 1.17
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angew Chem Int Ed Engl (2007) 1.17
Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast. Eukaryot Cell (2010) 1.16
Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities. Antimicrob Agents Chemother (2003) 1.14
Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum. Am J Trop Med Hyg (2010) 1.14
Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria. Proteomics (2005) 1.14
The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. J Biol Chem (2010) 1.13
Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro. Antimicrob Agents Chemother (2009) 1.12
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. J Biol Chem (2012) 1.10
Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites. J Biol Chem (2002) 1.09
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum. J Med Chem (2002) 1.09
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angew Chem Int Ed Engl (2010) 1.07
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells. Bioorg Med Chem (2008) 1.07
In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003. Malar J (2005) 1.07
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. J Antimicrob Chemother (2013) 1.07
The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store. J Biol Chem (2003) 1.05
Glycerophospholipid acquisition in Plasmodium - a puzzling assembly of biosynthetic pathways. Int J Parasitol (2010) 1.04
Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein. Tuberculosis (Edinb) (2007) 1.04
A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 1.03
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. Curr Top Med Chem (2006) 1.01
Symmetrical choline-derived dications display strong anti-kinetoplastid activity. J Antimicrob Chemother (2010) 1.01
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. J Med Chem (2009) 1.01
Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays. Methods Enzymol (2009) 1.01
Susceptibility of human Plasmodium knowlesi infections to anti-malarials. Malar J (2013) 1.01
Parasites bearing a single copy of the multi-drug resistance gene (pfmdr-1) with wild-type SNPs predominate amongst Plasmodium falciparum isolates from Malawi. Acta Trop (2009) 1.00
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. J Med Chem (2003) 1.00
Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog (2011) 0.99
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem (2010) 0.98
Glutathione transport: a new role for PfCRT in chloroquine resistance. Antioxid Redox Signal (2012) 0.97
Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. Antimicrob Agents Chemother (2006) 0.96
A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites. Biochem J (2008) 0.96
Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum. Malar J (2011) 0.96
Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH. Mol Biochem Parasitol (2002) 0.95
Antimalarial chemotherapy: young guns or back to the future? Trends Parasitol (2003) 0.95
Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Mol Pharmacol (2012) 0.94
Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation. Toxicology (2010) 0.93
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin. J Med Chem (2004) 0.92
Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation. Cell Microbiol (2011) 0.92