Published in Int J Parasitol on July 01, 2010
Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole. PLoS Pathog (2016) 2.07
Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection. Cell Host Microbe (2014) 1.66
Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J Exp Med (2011) 1.43
Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites. Proc Natl Acad Sci U S A (2013) 1.00
Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum. J Biol Chem (2013) 0.96
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. Prog Lipid Res (2013) 0.96
Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathog (2015) 0.87
Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate. Br J Pharmacol (2012) 0.86
Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. J Infect Dis (2012) 0.86
Choline analogues in malaria chemotherapy. Curr Pharm Des (2012) 0.83
Nematode phospholipid metabolism: an example of closing the genome-structure-function circle. Trends Parasitol (2014) 0.81
In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound. J Biol Chem (2013) 0.81
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLoS Pathog (2015) 0.78
Metabolic Signature Profiling as a Diagnostic and Prognostic Tool in Pediatric Plasmodium falciparum Malaria. Open Forum Infect Dis (2015) 0.78
New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial. Antimicrob Agents Chemother (2014) 0.78
Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast. Cell Microbiol (2016) 0.76
Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrob Agents Chemother (2014) 0.76
Host cell remodeling by pathogens: the exomembrane system in Plasmodium-infected erythrocytes. FEMS Microbiol Rev (2016) 0.76
Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways. BMC Syst Biol (2013) 0.75
Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase. PLoS Pathog (2016) 0.75
Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death. Sci Rep (2016) 0.75
Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria. PLoS One (2017) 0.75
A class of potent antimalarials and their specific accumulation in infected erythrocytes. Science (2002) 2.27
In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolism. Antimicrob Agents Chemother (2003) 1.25
Cysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins. FEBS Lett (2011) 1.19
Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast. Eukaryot Cell (2010) 1.16
Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs. Blood (2004) 1.16
Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities. Antimicrob Agents Chemother (2003) 1.14
Symmetrical choline-derived dications display strong anti-kinetoplastid activity. J Antimicrob Chemother (2010) 1.01
Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog (2011) 0.99
Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. Antimicrob Agents Chemother (2006) 0.96
Quantitative assessment of DNA replication to monitor microgametogenesis in Plasmodium berghei. Mol Biochem Parasitol (2009) 0.92
Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation. Cell Microbiol (2011) 0.92
Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways. J Lipid Res (2010) 0.90
The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages. Mol Biochem Parasitol (2010) 0.89
Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria. Antimicrob Agents Chemother (2008) 0.88
A 24 bp cis-acting element essential for the transcriptional activity of Plasmodium falciparum CDP-diacylglycerol synthase gene promoter. Mol Biochem Parasitol (2002) 0.88
Dual molecules as new antimalarials. Comb Chem High Throughput Screen (2005) 0.87
A novel live-dead staining methodology to study malaria parasite viability. Malar J (2013) 0.85
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
Characterisation of the phosphatidylinositol synthase gene of Plasmodium species. Res Microbiol (2006) 0.80
Genetic and transcriptional analysis of phosphoinositide-specific phospholipase C in Plasmodium. Exp Parasitol (2011) 0.80
Quantification of antimalarial bisthiazolium compounds and their neutral bioprecursors in plasma by liquid chromatography-electrospray mass spectrometry. Clin Chem (2005) 0.79
Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. Mol Biochem Parasitol (2013) 0.79
PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity. J Biol Chem (2011) 0.78
Plasmodium CDP-DAG synthase: an atypical gene with an essential N-terminal extension. Int J Parasitol (2010) 0.78
Pharmacological properties of a new antimalarial bisthiazolium salt, T3, and a corresponding prodrug, TE3. Antimicrob Agents Chemother (2005) 0.78
Liquid chromatography-electrospray mass spectrometry determination of a bis-thiazolium compound with potent antimalarial activity and its neutral bioprecursor in human plasma, whole blood and red blood cells. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.78
New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation. J Med Chem (2013) 0.78
Quantitation of SAR97276 in mouse tissues by rapid resolution liquid chromatography-mass spectrometry. J Sep Sci (2009) 0.78
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active. Biochem J (2013) 0.77
Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities. J Med Chem (2012) 0.76
Erratum: SC83288 is a clinical development candidate for the treatment of severe malaria. Nat Commun (2017) 0.75
Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways. BMC Syst Biol (2013) 0.75
Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors. Eur J Pharm Sci (2010) 0.75