PubRank

Karl Tryggvason

Author PubWeight™ 167.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med 2003 4.77
2 Genomic instability in laminopathy-based premature aging. Nat Med 2005 4.54
3 A simplified laminin nomenclature. Matrix Biol 2005 3.81
4 Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet 2002 3.78
5 Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol 2010 3.70
6 Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 2005 3.31
7 The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell 2006 3.10
8 The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med 2004 2.46
9 X-linked Alport syndrome: natural history and genotype-phenotype correlations in girls and women belonging to 195 families: a "European Community Alport Syndrome Concerted Action" study. J Am Soc Nephrol 2003 2.12
10 MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog 2009 2.12
11 Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. Kidney Int 2003 2.03
12 Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration. Hum Mol Genet 2002 1.85
13 Laminin isoforms in tumor invasion, angiogenesis and metastasis. Semin Cancer Biol 2002 1.83
14 Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin. Transplantation 2002 1.83
15 Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. Mol Cell Biol 2002 1.81
16 New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet 2012 1.79
17 New insights into the role of podocytes in proteinuria. Nat Rev Nephrol 2009 1.77
18 Nephrin--a unique structural and signaling protein of the kidney filter. Trends Mol Med 2007 1.74
19 Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J 2006 1.69
20 Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. J Clin Invest 2004 1.67
21 MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis. Dev Cell 2012 1.65
22 Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitro. Stem Cells 2008 1.62
23 MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol 2005 1.53
24 Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J 2003 1.53
25 Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med 2007 1.53
26 Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest 2007 1.52
27 CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest 2011 1.49
28 Functional diversity of laminins. Annu Rev Cell Dev Biol 2012 1.45
29 Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol 2005 1.42
30 Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo. EMBO Rep 2011 1.40
31 Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins. Blood 2006 1.39
32 A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis. J Immunol 2003 1.38
33 Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy. Diabetes 2012 1.36
34 Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol 2008 1.36
35 Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res 2004 1.36
36 Nephrin promotes cell-cell adhesion through homophilic interactions. Am J Pathol 2003 1.36
37 Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol 2002 1.34
38 Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. J Am Soc Nephrol 2007 1.33
39 SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood 2010 1.33
40 Contributions of the LG modules and furin processing to laminin-2 functions. J Biol Chem 2002 1.28
41 Heparan sulfate of perlecan is involved in glomerular filtration. J Am Soc Nephrol 2005 1.28
42 A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Dev Biol 2009 1.26
43 Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells. J Biol Chem 2002 1.26
44 N-linked glycosylation is critical for the plasma membrane localization of nephrin. J Am Soc Nephrol 2002 1.25
45 Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2. Proc Natl Acad Sci U S A 2002 1.24
46 Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun 2010 1.23
47 Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs. EMBO J 2002 1.22
48 Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem 2005 1.22
49 Glcci1 deficiency leads to proteinuria. J Am Soc Nephrol 2011 1.19
50 Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab 2012 1.18
51 Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition. J Biol Chem 2007 1.15
52 Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation. Circ Res 2008 1.15
53 Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology. Curr Opin Nephrol Hypertens 2011 1.14
54 Characterization of recombinant soluble macrophage scavenger receptor MARCO. J Biol Chem 2002 1.12
55 Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. Blood 2002 1.11
56 Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J Immunol 2005 1.11
57 Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol 2007 1.10
58 Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med 2009 1.10
59 Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. Nephrol Dial Transplant 2009 1.09
60 Defective trafficking of nephrin missense mutants rescued by a chemical chaperone. J Am Soc Nephrol 2004 1.07
61 Stem cell therapy for Alport syndrome: the hope beyond the hype. Nephrol Dial Transplant 2008 1.07
62 MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis. Eur J Immunol 2006 1.07
63 Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow. FASEB J 2007 1.07
64 Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis. J Biol Chem 2004 1.07
65 The glomerular transcriptome and a predicted protein-protein interaction network. J Am Soc Nephrol 2007 1.07
66 Amino acid transporter LAT3 is required for podocyte development and function. J Am Soc Nephrol 2009 1.06
67 Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO. Biochem Biophys Res Commun 2002 1.06
68 Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations. Lancet 2002 1.06
69 Increased intimal hyperplasia and smooth muscle cell proliferation in transgenic mice with heparan sulfate-deficient perlecan. Circ Res 2004 1.05
70 Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin. Exp Cell Res 2007 1.04
71 Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane. Kidney Int 2004 1.04
72 Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (alpha2beta1gamma1), 8 (alpha4beta1gamma1), 10 (alpha5beta1gamma1). Matrix Biol 2005 1.03
73 Impeded interaction between Schwann cells and axons in the absence of laminin alpha4. J Neurosci 2005 1.02
74 Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors. Exp Cell Res 2010 1.01
75 Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice. Cancer Res 2004 1.00
76 Podocin-green fluorescence protein allows visualization and functional analysis of podocytes. J Am Soc Nephrol 2011 0.99
77 Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus. Am J Hum Genet 2008 0.98
78 Characterization of the interactions of the nephrin intracellular domain. FEBS J 2005 0.98
79 Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria. Am J Nephrol 2009 0.98
80 Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome. Nephrol Dial Transplant 2003 0.98
81 Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. J Am Soc Nephrol 2013 0.98
82 Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro. Mol Cell Neurosci 2008 0.97
83 A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses. Eur J Immunol 2010 0.97
84 Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells. Blood 2007 0.96
85 Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn 2011 0.95
86 Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. Exp Cell Res 2008 0.94
87 Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. J Am Soc Nephrol 2007 0.94
88 Localization of laminin alpha4-chain in developing and adult human tissues. J Histochem Cytochem 2002 0.94
89 Towards understanding the inherited susceptibility for nephropathy in diabetes. Curr Opin Nephrol Hypertens 2012 0.93
90 SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors. J Innate Immun 2008 0.92
91 Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells. Blood 2007 0.91
92 Tissue expression of nephrin in human and pig. Pediatr Res 2004 0.91
93 An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. Blood 2004 0.90
94 Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol 2008 0.90
95 Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice. Cell Tissue Res 2003 0.90
96 Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics. Kidney Int 2012 0.90
97 Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis in vivo. Int J Cancer 2009 0.88
98 Pdlim2 is a novel actin-regulating protein of podocyte foot processes. Kidney Int 2011 0.88
99 Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release. Diabetes 2009 0.87
100 Identification of N-linked glycosylation sites in human nephrin using mass spectrometry. J Mass Spectrom 2007 0.87
101 Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice. Connect Tissue Res 2003 0.86
102 Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin. J Am Soc Nephrol 2003 0.86
103 A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO. J Biol Chem 2006 0.85
104 Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function. Lab Invest 2007 0.84
105 Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. J Biol Chem 2010 0.83
106 The podocyte protein nephrin is required for cardiac vessel formation. Hum Mol Genet 2011 0.83
107 Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis. Nephron Exp Nephrol 2010 0.83
108 Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes. Diabetologia 2014 0.83
109 Expression of nephrin in acquired human glomerular disease. Nephrol Dial Transplant 2002 0.82
110 Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. Kidney Int 2012 0.82
111 Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Proc Natl Acad Sci U S A 2011 0.81
112 Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome. Nephrol Dial Transplant 2008 0.81
113 Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type. Pediatr Nephrol 2006 0.81
114 Expression of novel podocyte-associated proteins sult1b1 and ankrd25. Nephron Exp Nephrol 2010 0.81
115 The glomerular transcriptome and proteome. Nephron Exp Nephrol 2007 0.80
116 Monoclonal antibodies to human nephrin. Hybrid Hybridomics 2004 0.80
117 Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice. J Invest Dermatol 2004 0.80
118 Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria. Nephron Exp Nephrol 2010 0.80
119 Knocking out podocyte rho GTPases: and the winner is... J Am Soc Nephrol 2012 0.79
120 A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland. BMC Genet 2007 0.79
121 Megakaryocytic cells synthesize and platelets secrete alpha5-laminins, and the endothelial laminin isoform laminin 10 (alpha5beta1gamma1) strongly promotes adhesion but not activation of platelets. Thromb Haemost 2006 0.79
122 Laminin-5 gamma2 chain expression facilitates detection of invasive squamous cell carcinoma of the uterine cervix. Int J Gynecol Pathol 2004 0.79
123 Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome. Lab Invest 2008 0.79
124 Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes. PLoS One 2013 0.79
125 Chondroitin sulphate modification in the alpha4 chain of human recombinant laminin-8 (alpha4beta1gamma1). Matrix Biol 2002 0.78
126 Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification. Diabetologia 2014 0.78
127 Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice. Neuroreport 2004 0.78
128 Sp1 specifically binds to an evolutionarily conserved DNA segment within a region necessary for podocyte-specific expression of nephrin. Nephron Exp Nephrol 2009 0.77
129 Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice. Am J Pathol 2013 0.77
130 A novel scavenger receptor 5-based antibiotic-independent selection method for generation of stable recombinant protein-producing mammalian cell lines especially suitable for proteins affecting cell adhesion. Biotechniques 2012 0.77
131 Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin. J Immunol 2009 0.76
132 Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy. Pediatr Nephrol 2012 0.76
133 A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy. PLoS One 2013 0.75
134 Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin. PLoS One 2015 0.75
135 A meta-analysis of expression signatures in glomerular disease. Kidney Int 2013 0.75