Published in Eur J Biochem on July 01, 2004
Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of Candida albicans: implications for antifungal drug target discovery. Eukaryot Cell (2006) 1.11
Crystallization and preliminary X-ray crystallographic study of phosphoglucose isomerase from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.78
Crystallization and preliminary X-ray characterization of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.77
Crystallization and preliminary crystallographic study of the phosphoglucose isomerase from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei. J Biol Chem (2005) 1.60
Plant-like traits associated with metabolism of Trypanosoma parasites. Proc Natl Acad Sci U S A (2003) 1.59
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes. Proc Natl Acad Sci U S A (2008) 1.37
Autophagy in protists. Autophagy (2011) 1.29
Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.26
Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei. Autophagy (2008) 1.25
Autophagy in parasitic protists: unique features and drug targets. Mol Biochem Parasitol (2011) 1.19
ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation. J Biol Chem (2003) 1.15
Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia. FEMS Immunol Med Microbiol (2007) 1.13
When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle. Int J Parasitol (2011) 1.08
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model. J Biol Chem (2010) 1.06
Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev (2004) 1.02
Complex I of Trypanosomatidae: does it exist? Trends Parasitol (2008) 1.01
Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Bioorg Med Chem (2009) 1.01
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J Biol Chem (2011) 1.00
Rewiring and regulation of cross-compartmentalized metabolism in protists. Philos Trans R Soc Lond B Biol Sci (2010) 0.97
Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. J Mol Biol (2008) 0.97
Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei. Biochim Biophys Acta (2007) 0.96
Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target. Enzyme Res (2011) 0.95
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. J Med Chem (2010) 0.95
A domino effect in drug action: from metabolic assault towards parasite differentiation. Mol Microbiol (2010) 0.95
Leishmania mexicana: molecular cloning and characterization of enolase. Exp Parasitol (2007) 0.95
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp. Mol Biochem Parasitol (2006) 0.94
The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis. FEBS Lett (2002) 0.93
Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state. J Mol Biol (2008) 0.93
Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins. Eur J Biochem (2003) 0.92
Horizontal gene transfer in trypanosomatids. Trends Parasitol (2007) 0.92
Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem (2008) 0.91
Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids. Curr Opin Microbiol (2014) 0.90
Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei. Mol Biochem Parasitol (2009) 0.90
Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi. Mol Biochem Parasitol (2003) 0.89
Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei. J Med Chem (2006) 0.89
Glycosomal ABC transporters of Trypanosoma brucei: characterisation of their expression, topology and substrate specificity. Int J Parasitol (2010) 0.89
Identification and characterization of three peroxins--PEX6, PEX10 and PEX12--involved in glycosome biogenesis in Trypanosoma brucei. Biochim Biophys Acta (2005) 0.89
Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PLoS One (2012) 0.89
Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for anti-parasite chemotherapy. Eur J Cell Biol (2010) 0.88
Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct. J Mol Biol (2003) 0.88
The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases. J Mol Biol (2008) 0.86
The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei. J Mol Biol (2006) 0.86
An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.85
The silicon trypanosome. Parasitology (2010) 0.85
Evaluation of monocot and eudicot divergence using the sugarcane transcriptome. Plant Physiol (2004) 0.84
Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids. Mol Biochem Parasitol (2010) 0.84
Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry (2003) 0.84
Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase. Eur J Biochem (2003) 0.84
The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition. J Mol Biol (2003) 0.84
Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase. FEBS J (2012) 0.83
Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei. Biochim Biophys Acta (2009) 0.83
Fumarate hydratase isoforms of Leishmania major: subcellular localization, structural and kinetic properties. Int J Biol Macromol (2012) 0.83
An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Mol Biochem Parasitol (2010) 0.83
Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting. Mol Membr Biol (2006) 0.82
Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo. Metallomics (2011) 0.81
Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis. FEBS Lett (2012) 0.81
Leishmania donovani phosphofructokinase. Gene characterization, biochemical properties and structure-modeling studies. Eur J Biochem (2002) 0.81
The multifunctional isopropyl alcohol dehydrogenase of Phytomonas sp. could be the result of a horizontal gene transfer from a bacterium to the trypanosomatid lineage. J Biol Chem (2003) 0.81
6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis. FEBS J (2005) 0.81
Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei. Biochem Biophys Res Commun (2011) 0.81
Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. PLoS One (2010) 0.80
Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp. Mol Biochem Parasitol (2007) 0.80
Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux. J Biol Chem (2013) 0.80
The characterization and evolutionary relationships of a trypanosomal thiolase. Int J Parasitol (2011) 0.80
Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features. Biochim Biophys Acta (2013) 0.80
`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase. Acta Crystallogr D Biol Crystallogr (2013) 0.80
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS Negl Trop Dis (2013) 0.79
The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes. J Mol Biol (2007) 0.79
Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs. Parasitology (2012) 0.79
Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol Microbiol (2014) 0.79
Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors. J Med Chem (2012) 0.78
Glucose-6-phosphate dehydrogenase of trypanosomatids: characterization, target validation, and drug discovery. Mol Biol Int (2011) 0.78
Leishmania mexicana mexicana glucose-6-phosphate isomerase: crystallization, molecular-replacement solution and inhibition. Acta Crystallogr D Biol Crystallogr (2004) 0.78
Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2. Int J Parasitol (2012) 0.78
Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham. Z Naturforsch C (2008) 0.78
Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass. J Mol Biol (2009) 0.78
Studies on the organization of the docking complex involved in matrix protein import into glycosomes of Trypanosoma brucei. Biochem Biophys Res Commun (2012) 0.77
Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem (2014) 0.77
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. Biochem J (2012) 0.77
Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition. Biochemistry (2002) 0.77
Pyruvate kinases have an intrinsic and conserved decarboxylase activity. Biochem J (2014) 0.76
The evolution of organellar metabolism in unicellular eukaryotes. Philos Trans R Soc Lond B Biol Sci (2010) 0.75
Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
Biochemical effects of riluzole on Leishmania parasites. Exp Parasitol (2012) 0.75
Processing of the glycosomal matrix-protein import receptor PEX5 of Trypanosoma brucei. Biochem Biophys Res Commun (2012) 0.75
Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop. Biochem J (2013) 0.75
Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target. J Biochem (2013) 0.75