Published in Mol Biochem Parasitol on December 23, 2007
Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics (2009) 2.00
A comprehensive analysis of Trypanosoma brucei mitochondrial proteome. Proteomics (2009) 1.94
Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics. Proteomics (2009) 1.75
Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. BMC Genomics (2009) 1.68
Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry. BMC Genomics (2012) 1.31
Lipid metabolism in Trypanosoma brucei. Mol Biochem Parasitol (2010) 1.16
Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes. BMC Genomics (2010) 1.16
Comparative proteomics of two life cycle stages of stable isotope-labeled Trypanosoma brucei reveals novel components of the parasite's host adaptation machinery. Mol Cell Proteomics (2012) 1.14
Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter. Nat Commun (2013) 1.12
High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics. J Proteome Res (2014) 1.04
The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation. RNA (2013) 1.02
Subcellular proteomics of Trypanosoma cruzi reservosomes. Proteomics (2009) 0.97
Rewiring and regulation of cross-compartmentalized metabolism in protists. Philos Trans R Soc Lond B Biol Sci (2010) 0.97
Biochemical analysis of PIFTC3, the Trypanosoma brucei orthologue of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components. Mol Microbiol (2010) 0.91
Protein composition of Trypanosoma brucei mitochondrial membranes. Proteomics (2009) 0.89
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice. Mol Microbiol (2010) 0.88
The double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics. Biomed Res Int (2014) 0.85
Biased cellular locations of tandem repeat antigens in African trypanosomes. Biochem Biophys Res Commun (2011) 0.83
Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei. F1000Res (2013) 0.82
Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei. PLoS Comput Biol (2013) 0.81
ATPaseTb2, a unique membrane-bound FoF1-ATPase component, is essential in bloodstream and dyskinetoplastic trypanosomes. PLoS Pathog (2015) 0.80
Glucose-6-phosphate dehydrogenase of trypanosomatids: characterization, target validation, and drug discovery. Mol Biol Int (2011) 0.78
Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense. Antimicrob Agents Chemother (2016) 0.77
RNA editing and mitochondrial activity in promastigotes and amastigotes of Leishmania donovani. Int J Parasitol (2008) 0.77
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod (2013) 0.76
Comprehensive proteomics analysis of glycosomes from Leishmania donovani. OMICS (2015) 0.76
Using fluorescent proteins to monitor glycosome dynamics in the African trypanosome. J Vis Exp (2014) 0.76
The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids. PLoS One (2017) 0.76
Glycosome biogenesis in trypanosomes and the de novo dilemma. PLoS Negl Trop Dis (2017) 0.75
Analysis of the Trypanosoma brucei EATRO 164 Bloodstream Guide RNA Transcriptome. PLoS Negl Trop Dis (2016) 0.75
The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei. J Eukaryot Microbiol (2016) 0.75
Metabolic reprogramming during the Trypanosoma brucei life cycle. F1000Res (2017) 0.75
Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus. Physiol Genomics (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. J Biol Chem (2003) 2.45
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J Am Soc Nephrol (2003) 1.77
Identification of a dehydrogenase acting on D-2-hydroxyglutarate. Biochem J (2004) 1.72
Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei. J Biol Chem (2005) 1.60
PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli. Biochem J (2013) 1.60
Plant-like traits associated with metabolism of Trypanosoma parasites. Proc Natl Acad Sci U S A (2003) 1.59
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J Physiol (2005) 1.47
Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem (2003) 1.46
Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems. J Mol Evol (2002) 1.45
Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett (2002) 1.41
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes. Proc Natl Acad Sci U S A (2008) 1.37
In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes. Mol Biochem Parasitol (2006) 1.36
Evolution of energy metabolism and its compartmentation in Kinetoplastida. Kinetoplastid Biol Dis (2003) 1.33
The presence of four iron-containing superoxide dismutase isozymes in trypanosomatidae: characterization, subcellular localization, and phylogenetic origin in Trypanosoma brucei. Free Radic Biol Med (2005) 1.31
Autophagy in protists. Autophagy (2011) 1.29
Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei. Autophagy (2008) 1.25
The disulphide isomerase DsbC cooperates with the oxidase DsbA in a DsbD-independent manner. Mol Microbiol (2007) 1.21
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J Biol Chem (2008) 1.19
Autophagy in parasitic protists: unique features and drug targets. Mol Biochem Parasitol (2011) 1.19
Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis. Proc Natl Acad Sci U S A (2008) 1.18
ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation. J Biol Chem (2003) 1.15
New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle. J Biol Chem (2005) 1.14
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol (2006) 1.11
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. J Biol Chem (2003) 1.10
When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle. Int J Parasitol (2011) 1.08
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J Nat Prod (2007) 1.07
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model. J Biol Chem (2010) 1.06
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity. J Biol Chem (2005) 1.03
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochem J (2012) 1.03
Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways. J Mol Cell Cardiol (2002) 1.02
Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev (2004) 1.02
Complex I of Trypanosomatidae: does it exist? Trends Parasitol (2008) 1.01
Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Bioorg Med Chem (2009) 1.01
Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. J Biol Chem (2004) 1.01
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J Biol Chem (2011) 1.00
Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. J Biol Chem (2010) 0.99
The AMP-activated protein kinase: more than an energy sensor. Essays Biochem (2007) 0.98
Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation. Comp Biochem Physiol B Biochem Mol Biol (2005) 0.97
Rewiring and regulation of cross-compartmentalized metabolism in protists. Philos Trans R Soc Lond B Biol Sci (2010) 0.97
Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. J Mol Biol (2008) 0.97
AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells. Biochem Biophys Res Commun (2010) 0.97
Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei. Biochim Biophys Acta (2007) 0.96
Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target. Enzyme Res (2011) 0.95
A domino effect in drug action: from metabolic assault towards parasite differentiation. Mol Microbiol (2010) 0.95
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. J Med Chem (2010) 0.95
Leishmania mexicana: molecular cloning and characterization of enolase. Exp Parasitol (2007) 0.95
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp. Mol Biochem Parasitol (2006) 0.94
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochem J (2012) 0.94
The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis. FEBS Lett (2002) 0.93
Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. J Biol Chem (2004) 0.93
Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes. FEBS Lett (2008) 0.93
Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state. J Mol Biol (2008) 0.93
Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins. Eur J Biochem (2003) 0.92
Horizontal gene transfer in trypanosomatids. Trends Parasitol (2007) 0.92
Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK. Cell Signal (2007) 0.92
Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem (2008) 0.91
Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei. Mol Biochem Parasitol (2009) 0.90
Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids. Curr Opin Microbiol (2014) 0.90
Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi. Mol Biochem Parasitol (2003) 0.89
Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei. J Med Chem (2006) 0.89
Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PLoS One (2012) 0.89
Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle. Pflugers Arch (2007) 0.89
Identification and characterization of three peroxins--PEX6, PEX10 and PEX12--involved in glycosome biogenesis in Trypanosoma brucei. Biochim Biophys Acta (2005) 0.89
Glycosomal ABC transporters of Trypanosoma brucei: characterisation of their expression, topology and substrate specificity. Int J Parasitol (2010) 0.89
A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle. Biochem J (2012) 0.88
Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for anti-parasite chemotherapy. Eur J Cell Biol (2010) 0.88
Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct. J Mol Biol (2003) 0.88
Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle. Cell Signal (2013) 0.87
The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features. Eur J Biochem (2004) 0.86
The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei. J Mol Biol (2006) 0.86
The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases. J Mol Biol (2008) 0.86
An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.85
The silicon trypanosome. Parasitology (2010) 0.85
Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids. Mol Biochem Parasitol (2010) 0.84
The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism. FEBS Lett (2002) 0.84
The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition. J Mol Biol (2003) 0.84
Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry (2003) 0.84
Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing. Cell Signal (2004) 0.84
Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase. Eur J Biochem (2003) 0.84
Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase. FEBS J (2012) 0.83
Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei. Biochim Biophys Acta (2009) 0.83
Fumarate hydratase isoforms of Leishmania major: subcellular localization, structural and kinetic properties. Int J Biol Macromol (2012) 0.83
An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Mol Biochem Parasitol (2010) 0.83
Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle. Chem Biol (2014) 0.82
Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting. Mol Membr Biol (2006) 0.82
Regulation of PIKfyve phosphorylation by insulin and osmotic stress. Biochem Biophys Res Commun (2010) 0.82
Theiler's virus L protein is targeted to the mitochondrial outer membrane. J Virol (2011) 0.82
The multifunctional isopropyl alcohol dehydrogenase of Phytomonas sp. could be the result of a horizontal gene transfer from a bacterium to the trypanosomatid lineage. J Biol Chem (2003) 0.81
Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo. Metallomics (2011) 0.81
Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis. FEBS Lett (2012) 0.81