Published in Oncogene on August 12, 2004
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J Exp Med (2006) 3.47
From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer (2012) 2.46
Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma. PLoS One (2012) 2.40
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res (2008) 2.18
Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3. J Clin Invest (2013) 2.11
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A (2010) 2.03
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res (2005) 1.93
Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer (2005) 1.66
A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid (2009) 1.53
BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res (2011) 1.47
Analysis of the genome to personalize therapy for melanoma. Oncogene (2010) 1.33
Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. Oncotarget (2013) 1.32
Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032. Neoplasia (2011) 1.26
BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ (2012) 1.24
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. Cancer Res (2009) 1.21
TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells. Cancer Res (2012) 1.20
Detection of mutant BRAF alleles in the plasma of patients with metastatic melanoma. J Mol Diagn (2007) 1.18
RNA interference in biology and disease. Blood (2005) 1.18
B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol Biol Cell (2007) 1.15
Functional RET G691S polymorphism in cutaneous malignant melanoma. Oncogene (2009) 1.14
Nanovehicular intracellular delivery systems. J Pharm Sci (2008) 1.10
Understanding signaling cascades in melanoma. Photochem Photobiol (2007) 1.10
FOXD3 regulates migration properties and Rnd3 expression in melanoma cells. Mol Cancer Res (2011) 1.05
Staging and prognosis of cutaneous melanoma. Surg Oncol Clin N Am (2011) 0.98
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene (2011) 0.98
BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications. Oncotarget (2014) 0.92
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment. Front Endocrinol (Lausanne) (2013) 0.92
Targeted therapy for melanoma: a primer. Surg Oncol Clin N Am (2011) 0.89
Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation. Int Immunol (2016) 0.88
Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations. BMC Cancer (2009) 0.86
Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients. Oncol Lett (2010) 0.85
Improvement of cancer immunotherapy by combining molecular targeted therapy. Front Oncol (2013) 0.85
Mutant B-RAF regulates a Rac-dependent cadherin switch in melanoma. Oncogene (2012) 0.84
Optimization of feline immunodeficiency virus vectors for RNA interference. J Virol (2006) 0.80
Snowball: resampling combined with distance-based regression to discover transcriptional consequences of a driver mutation. Bioinformatics (2014) 0.79
CXCR7 expression in nasopharyngeal carcinoma tissues correlates with disease severity. Int J Clin Exp Med (2015) 0.78
Melanoma: oncogenic drivers and the immune system. Ann Transl Med (2015) 0.78
Inhibitory RNA molecules in immunotherapy for cancer. Methods Mol Biol (2010) 0.77
Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system. Int J Clin Exp Pathol (2015) 0.76
In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging. Anal Bioanal Chem (2015) 0.76
Inducible Mouse Models for Cancer Drug Target Validation. J Cancer Prev (2016) 0.75
Immunological research using RNA interference technology. Immunology (2007) 0.75
Ran signaling in melanoma: implications for the development of alternative therapeutic strategies. Cancer Lett (2014) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature (2007) 13.56
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Generation of transgenic non-human primates with germline transmission. Nature (2009) 4.06
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J Exp Med (2006) 3.47
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell (2009) 3.22
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 3.21
Retracted Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 3.12
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes (2009) 2.54
The role of stromal stem cells in tissue regeneration and wound repair. Science (2009) 2.51
Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clin Cancer Res (2011) 2.44
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet (2007) 2.39
Defective vasculogenesis in systemic sclerosis. Lancet (2004) 2.38
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease. Arthritis Rheum (2009) 2.37
Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011) 2.34
Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32
Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res (2003) 2.31
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A (2005) 2.31
Increase in circulating endothelial precursors by atorvastatin in patients with systemic sclerosis. Arthritis Rheum (2006) 2.19
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages. Blood (2003) 2.01
Efficient colonic mucosal wound repair requires Trem2 signaling. Proc Natl Acad Sci U S A (2008) 1.93
CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med (2003) 1.82
In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. FASEB J (2005) 1.80
Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. Gastroenterology (2012) 1.77
Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol (2003) 1.76
DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell (2006) 1.75
Retracted Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase. EMBO Rep (2002) 1.72
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65
Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. J Endocrinol (2006) 1.64
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res (2002) 1.62
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res (2002) 1.60
MTA for obturation of mandibular central incisors with open apices: case report. J Endod (2004) 1.53
A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. PLoS One (2013) 1.51
Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr Biol (2005) 1.49
The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA. Chem Rev (1998) 1.49
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene (2004) 1.48
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One (2011) 1.48
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J (2013) 1.47
Retracted Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.44
Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells. PLoS One (2013) 1.43
Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J Gene Med (2004) 1.43
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology (2007) 1.42
Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation. J Biol Chem (2006) 1.39
Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability. Cancer Res (2003) 1.38
Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells. Stem Cells (2005) 1.38
Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine. J Biol Chem (2010) 1.37
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol (2006) 1.35
Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology. J Transl Med (2009) 1.31
Sequence-specific interference by small RNAs derived from adenovirus VAI RNA. FEBS Lett (2006) 1.31
Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev (2003) 1.28
Generation of human melanocytes from induced pluripotent stem cells. PLoS One (2011) 1.27
Functional analysis of microRNAs during the retinoic acid-induced neuronal differentiation of human NT2 cells. Nucleic Acids Res Suppl (2003) 1.27
Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther (2004) 1.26
Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res (2004) 1.26
p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res (2005) 1.25
Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice. Proc Natl Acad Sci U S A (2007) 1.25
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene (2005) 1.25
Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res (2004) 1.24
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Res (2003) 1.23
Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res (2008) 1.21
Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. J Biol Chem (2002) 1.21
Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. Clin Dev Immunol (2013) 1.20
Endothelial differentiation potential of human monocyte-derived multipotential cells. Stem Cells (2006) 1.20
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology (2005) 1.19
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf) (2005) 1.18
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett (2010) 1.18
Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium. PLoS One (2012) 1.17
Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest (2014) 1.15
Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery. J Neurosci Res (2004) 1.15
Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. Antisense Nucleic Acid Drug Dev (2002) 1.15