Published in Nucleic Acids Res on January 15, 2003
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res (2004) 5.46
Evidence for nuclear processing of plant micro RNA and short interfering RNA precursors. Plant Physiol (2003) 3.16
EST analyses predict the existence of a population of chimeric microRNA precursor-mRNA transcripts expressed in normal human and mouse tissues. Genome Biol (2003) 2.46
Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Genes Dev (2004) 2.00
An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucleic Acids Res (2005) 1.83
RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors. Proc Natl Acad Sci U S A (2006) 1.66
Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA (2007) 1.46
MicroRNA: An emerging therapeutic target and intervention tool. Int J Mol Sci (2008) 1.41
pHUSH: a single vector system for conditional gene expression. BMC Biotechnol (2007) 1.27
Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Res (2004) 1.27
Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res (2004) 1.24
C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57. PLoS One (2009) 1.23
Promoter choice affects the potency of HIV-1 specific RNA interference. Nucleic Acids Res (2003) 1.22
Novel RNA-based strategies for therapeutic gene silencing. Mol Ther (2010) 1.20
Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease. Mol Ther (2009) 1.09
Advances in microRNAs: implications for gene therapists. Hum Gene Ther (2008) 1.08
Dicer-independent processing of short hairpin RNAs. Nucleic Acids Res (2013) 1.06
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A (2003) 1.06
A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs. J RNAi Gene Silencing (2005) 1.06
Optimization and characterization of tRNA-shRNA expression constructs. Nucleic Acids Res (2007) 1.02
Peculiarities of piRNA-mediated post-transcriptional silencing of Stellate repeats in testes of Drosophila melanogaster. Nucleic Acids Res (2009) 0.99
A plasmid-based system for expressing small interfering RNA libraries in mammalian cells. BMC Cell Biol (2004) 0.98
Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells. ACS Nano (2014) 0.97
Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics. Hum Mol Genet (2009) 0.97
Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression. Nat Protoc (2009) 0.96
A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain. Nucleic Acids Res (2007) 0.95
Complete, gene-specific siRNA libraries: production and expression in mammalian cells. RNA (2005) 0.90
MicroRNAs in Head and Neck Cancer. Int J Dent (2013) 0.88
Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity. Int J Biol Sci (2013) 0.88
Efficient downregulation of multiple mRNA targets with a single shRNA-expressing lentiviral vector. Plasmid (2010) 0.87
Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology. BMC Biotechnol (2007) 0.87
APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1. Mol Neurodegener (2007) 0.87
RNA interference for improving the outcome of islet transplantation. Adv Drug Deliv Rev (2010) 0.84
Personalized cancer approach: using RNA interference technology. World J Surg (2011) 0.83
Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA. Nucleic Acids Res (2011) 0.81
Design and characterization of a new peptide vector for short interfering RNA delivery. J Nanobiotechnology (2015) 0.81
Do small RNAs interfere with LINE-1? J Biomed Biotechnol (2006) 0.79
Non-viral nucleic acid containing nanoparticles as cancer therapeutics. Expert Opin Drug Deliv (2016) 0.79
Bioengineered nanoparticles for siRNA delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2013) 0.78
Identification of effective siRNA against K-ras in human pancreatic cancer cell line MiaPaCa-2 by siRNA expression cassette. World J Gastroenterol (2005) 0.76
Bioreducible Poly(Beta-Amino Ester)s for Intracellular Delivery of SiRNA. Methods Mol Biol (2016) 0.75
A significant increase of RNAi efficiency in human cells by the CMV enhancer with a tRNAlys promoter. J Biomed Biotechnol (2009) 0.75
Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs. Mol Ther Nucleic Acids (2017) 0.75
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47
A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24
Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell (1999) 13.48
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
On the role of RNA amplification in dsRNA-triggered gene silencing. Cell (2001) 9.78
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell (1999) 9.01
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A (2002) 8.57
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol (2002) 8.31
Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev (1999) 8.21
RNA interference--2001. Genes Dev (2001) 7.68
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr Biol (2000) 7.16
Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr Biol (2001) 7.06
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A (2002) 6.84
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell (2002) 6.43
Effective expression of small interfering RNA in human cells. Nat Biotechnol (2002) 6.02
Post-transcriptional gene silencing by double-stranded RNA. Nat Rev Genet (2001) 5.84
RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74
RNA-triggered gene silencing. Trends Genet (1999) 5.36
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 4.63
Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol Cell Biol (1992) 4.16
Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression. Trends Genet (1998) 3.65
Gene silencing using micro-RNA designed hairpins. RNA (2002) 3.21
The rest is silence. RNA (2001) 3.07
Viral suppressors of RNA silencing. Curr Opin Biotechnol (2001) 2.53
Structural requirements of double-stranded RNA for the activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells. J Biol Chem (1979) 2.43
RNA interference and small interfering RNAs. Chembiochem (2001) 2.40
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature (1998) 2.25
RNA interference in human cells is restricted to the cytoplasm. RNA (2002) 2.16
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA (1997) 1.84
Retracted Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase. EMBO Rep (2002) 1.72
Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P. Proc Natl Acad Sci U S A (1998) 1.50
Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells. J Biol Chem (2001) 1.19
Retracted Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat Biotechnol (2002) 1.08
RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA. Proc Natl Acad Sci U S A (2001) 1.08
Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III. J Virol (1999) 1.02
A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries. Nucleic Acids Res (2002) 0.98
Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cells. Nucleic Acids Res (2001) 0.97
Detection and quantitation of mutant K-ras codon 12 restriction fragments by capillary electrophoresis. Anal Biochem (1995) 0.87
Recognition of engineered tRNAs with an extended 3' end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells. Biomacromolecules (2001) 0.87
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Retracted Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 3.12
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene (2004) 1.76
Retracted Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase. EMBO Rep (2002) 1.72
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA. Chem Rev (1998) 1.49
Retracted Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.44
Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J Gene Med (2004) 1.43
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol (2006) 1.35
Sequence-specific interference by small RNAs derived from adenovirus VAI RNA. FEBS Lett (2006) 1.31
Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev (2003) 1.28
Functional analysis of microRNAs during the retinoic acid-induced neuronal differentiation of human NT2 cells. Nucleic Acids Res Suppl (2003) 1.27
Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther (2004) 1.26
Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res (2004) 1.26
p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res (2005) 1.25
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene (2005) 1.25
Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res (2004) 1.24
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology (2005) 1.19
Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf) (2005) 1.18
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. Antisense Nucleic Acid Drug Dev (2002) 1.15
Retracted siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res (2003) 1.14
Essential role of ATF-1 in induction of NOX1, a catalytic subunit of NADPH oxidase: involvement of mitochondrial respiratory chain. Biochem J (2005) 1.13
Involvement of template-activating factor I/SET in transcription of adenovirus early genes as a positive-acting factor. J Virol (2006) 1.12
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. Nucleic Acids Symp Ser (Oxf) (2004) 1.10
Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. Int J Cancer (2006) 1.09
Retracted Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat Biotechnol (2002) 1.08
Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J Biol Chem (2004) 1.07
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. J Cell Biol (2006) 1.07
Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Neurochem Int (2005) 1.06
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A (2003) 1.06
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60. Biochem J (2005) 1.06
Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300. Cancer Sci (2005) 1.05
Strategies for generation of an siRNA expression library directed against the human genome. Oligonucleotides (2003) 1.04
Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components. Nucleic Acids Res (2005) 1.04
Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis. Proc Natl Acad Sci U S A (2007) 1.03
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors. J Biol Chem (2004) 1.03
siRNA induced transcriptional gene silencing in mammalian cells. Cell Cycle (2005) 1.02
A direct and efficient synthesis method for dumbell-shaped linear DNA using PCR in vitro. Nucleic Acids Res Suppl (2003) 1.01
Retraction: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.00
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem (2002) 1.00
A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries. Nucleic Acids Res (2002) 0.98
Ligand-targeted delivery of therapeutic siRNA. Pharm Res (2006) 0.98
Development and application of siRNA expression vector. Nucleic Acids Res Suppl (2002) 0.96
Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme. Nucleic Acids Res (2002) 0.96
NMR-based reappraisal of the coordination of a metal ion at the pro-Rp oxygen of the A9/G10.1 site in a hammerhead ribozyme. J Am Chem Soc (2004) 0.95
Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression. J Pharmacol Exp Ther (2003) 0.95
Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. J Biol Chem (2004) 0.95
World of small RNAs: from ribozymes to siRNA and miRNA. Differentiation (2004) 0.94
Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells. J Gene Med (2004) 0.94
Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model. J Biol Chem (2005) 0.93
Quantum dots in bio-imaging: Revolution by the small. Biochem Biophys Res Commun (2005) 0.93
Gene discovery by ribozyme and siRNA libraries. Nat Rev Mol Cell Biol (2005) 0.93
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates. Cell Res (2003) 0.93
Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Biochem Biophys Res Commun (2003) 0.92
Transcriptional gene silencing by short interfering RNAs. Curr Opin Mol Ther (2005) 0.92
Position-specific incorporation of a fluorophore-quencher pair into a single streptavidin through orthogonal four-base codon/anticodon pairs. J Am Chem Soc (2002) 0.92
Mortalin: present and prospective. Exp Gerontol (2002) 0.92
Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA. Mol Biosyst (2005) 0.92
Vectors for RNA interference. Curr Opin Mol Ther (2004) 0.91
TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors. Int J Cancer (2006) 0.90
Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation. J Biol Chem (2004) 0.90
LIM kinase-2 targeting as a possible anti-metastasis therapy. J Gene Med (2004) 0.90
Comparison of metal-ion-dependent cleavages of RNA by a DNA enzyme and a hammerhead ribozyme. Biomacromolecules (2002) 0.89
A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids. Int J Pharm (2005) 0.89
Mouse microRNA-23b regulates expression of Hes1 gene in P19 cells. Nucleic Acids Symp Ser (Oxf) (2004) 0.89
siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme. Biochem Biophys Res Commun (2004) 0.88
Novel methods for expressing RNA interference in human cells. Methods Enzymol (2005) 0.88
RNAi expression vectors in mammalian cells. Methods Mol Biol (2004) 0.88
Transglutaminase-mediated N- and C-terminal fluorescein labeling of a protein can support the native activity of the modified protein. Protein Eng Des Sel (2004) 0.88
Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation. Proc Natl Acad Sci U S A (2002) 0.88
siRNA becomes smart and intelligent. Nat Biotechnol (2005) 0.88
Identification of the metal ion binding site on an RNA motif from hammerhead ribozymes using (15)N NMR spectroscopy. J Am Chem Soc (2002) 0.88
Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library. J Biol Chem (2005) 0.88
Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes. EMBO Rep (2003) 0.87
The NRSE smRNA specifies the fate of adult hippocampal neural stem cells. Nucleic Acids Symp Ser (Oxf) (2005) 0.87
Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression. Biochem Biophys Res Commun (2004) 0.87
Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme. Nucleic Acids Res (2004) 0.86
Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo. Cancer Res (2002) 0.86
Maxizymes and small hairpin-type RNAs that are driven by a tRNA promoter specifically cleave a chimeric gene associated with leukemia in vitro and in vivo. Cancer Res (2003) 0.86
Molecular design and delivery of siRNA. J Drug Target (2006) 0.85
Synthesis of a novel histidine analogue and its efficient incorporation into a protein in vivo. Protein Eng (2003) 0.85
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2006) 0.85
Generation of an shRNAi expression library against the whole human transcripts. Virus Res (2004) 0.84
Control of siRNA expression utilizing Cre-loxP recombination system. Nucleic Acids Res Suppl (2003) 0.84
Maxizyme technology. Methods Mol Biol (2004) 0.84
Determination of the role of DDX3 a factor involved in mammalian RNAi pathway using an shRNA-expression library. PLoS One (2013) 0.84
Cleavage of an inaccessible site by the maxizyme with two independent binding arms: an alternative approach to the recruitment of RNA helicases. J Biochem (2002) 0.83
Analysis on a cooperative pathway involving multiple cations in hammerhead reactions. J Am Chem Soc (2004) 0.83
Structural basis of the highly efficient trapping of the HIV Tat protein by an RNA aptamer. Structure (2003) 0.83